Positions

Selected Publications

Academic Article

Year Title Altmetric
2017 Activities of gyrase and topoisomerase IV on positively supercoiled DNA.Nucleic Acids Research.  45:9611-9624. 2017
2017 Interactions between Quinolones and Bacillus anthracis Gyrase and the Basis of Drug Resistance.Biochemistry.  56:4191-4200. 2017
2017 X-ray crystal structure of a reiterative transcription complex reveals an atypical RNA extension pathway.Proceedings of the National Academy of Sciences.  114:8211-8216. 2017
2015 Activity of quinolone CP-115,955 against bacterial and human type II topoisomerases is mediated by different interactions.Biochemistry.  54:1278-1286. 2015
2014 Bacillus anthracis GrlAV96A topoisomerase IV, a quinolone resistance mutation that does not affect the water-metal ion bridge.Antimicrobial Agents and Chemotherapy.  58:7182-7187. 2014
2014 Transcription start site sequence and spacing between the -10 region and the start site affect reiterative transcription-mediated regulation of gene expression in Escherichia coli.Journal of Bacteriology.  196:2912-2920. 2014
2014 Cryo-EM analysis of the organization of BclA and BxpB in the Bacillus anthracis exosporium.Journal of ultrastructure research.  186:181-187. 2014
2014 Microbicidal power of alpha radiation in sterilizing germinating Bacillus anthracis spores.Antimicrobial Agents and Chemotherapy.  58:1813-1815. 2014
2013 Overcoming target-mediated quinolone resistance in topoisomerase IV by introducing metal-ion-independent drug-enzyme interactions.ACS Chemical Biology.  8:2660-2668. 2013
2013 Topoisomerase IV-quinolone interactions are mediated through a water-metal ion bridge: mechanistic basis of quinolone resistance.Nucleic Acids Research.  41:4628-4639. 2013
2012 Variable lymphocyte receptor recognition of the immunodominant glycoprotein of Bacillus anthracis spores.Structure.  20:479-486. 2012
2012 Drug interactions with Bacillus anthracis topoisomerase IV: biochemical basis for quinolone action and resistance.Biochemistry.  51:370-381. 2012
2011 Regulation of gene expression by reiterative transcription.Current Opinion in Microbiology.  14:142-147. 2011
2011 An unusual mechanism of isopeptide bond formation attaches the collagenlike glycoprotein BclA to the exosporium of Bacillus anthracis.mBio.  2:e00084-e00011. 2011
2010 Characterization of the enzymes encoded by the anthrose biosynthetic operon of Bacillus anthracis.Journal of Bacteriology.  192:5053-5062. 2010
2010 ExsB, an unusually highly phosphorylated protein required for the stable attachment of the exosporium of Bacillus anthracis.Microbiological sciences.  76:1527-1538. 2010
2010 Sequence motifs and proteolytic cleavage of the collagen-like glycoprotein BclA required for its attachment to the exosporium of Bacillus anthracis.Journal of Bacteriology.  192:1259-1268. 2010
2009 Identification of the UDP-N-acetylglucosamine 4-epimerase involved in exosporium protein glycosylation in Bacillus anthracis.Journal of Bacteriology.  191:7094-7101. 2009
2009 CD14-Mac-1 interactions in Bacillus anthracis spore internalization by macrophages.Proceedings of the National Academy of Sciences.  106:13957-13962. 2009
2009 The spore-specific alanine racemase of Bacillus anthracis and its role in suppressing germination during spore development.Journal of Bacteriology.  191:1303-1310. 2009
2008 Regulation of bacterial gene expression by the NTP substrates of transcription initiation.Microbiological sciences.  69:10-14. 2008
2008 Regulation of pyrimidine biosynthetic gene expression in bacteria: repression without repressors.Microbiology and Molecular Biology Reviews.  72:266-300. 2008
2008 Anthrose biosynthetic operon of Bacillus anthracis.Journal of Bacteriology.  190:2350-2359. 2008
2008 Antibody responses of variable lymphocyte receptors in the lamprey.Nature Immunology.  9:319-327. 2008
2008 Structure and specificity of lamprey monoclonal antibodies.Proceedings of the National Academy of Sciences.  105:2040-2045. 2008
2008 The integrin Mac-1 (CR3) mediates internalization and directs Bacillus anthracis spores into professional phagocytes.Proceedings of the National Academy of Sciences.  105:1261-1266. 2008
2007 Systematic mutagenesis of the thymidine tract of the pyrBI attenuator and its effects on intrinsic transcription termination in Escherichia coli.Microbiological sciences.  66:127-138. 2007
2007 Non-uniform assembly of the Bacillus anthracis exosporium and a bottle cap model for spore germination and outgrowth.Microbiological sciences.  64:359-367. 2007
2006 The ExsY protein is required for complete formation of the exosporium of Bacillus anthracis.Journal of Bacteriology.  188:7440-7448. 2006
2006 The phage meeting: Classical venue, new momentum.Journal of Bacteriology.  188:4597-4600. 2006
2006 Monoclonal antibodies for Bacillus anthracis spore detection and functional analyses of spore germination and outgrowth.Journal of Immunology.  176:6076-6084. 2006
2005 Characterization of the exosporium basal layer protein BxpB of Bacillus anthracis.Journal of Bacteriology.  187:5868-5876. 2005
2005 Orientation within the exosporium and structural stability of the collagen-like glycoprotein BclA of Bacillus anthracis.Journal of Bacteriology.  187:5310-5317. 2005
2004 Diagnostic probes for Bacillus anthracis spores selected from a landscape phage library.Clinical Chemistry.  50:1899-1906. 2004
2004 Attenuation control of pyrG expression in Bacillus subtilis is mediated by CTP-sensitive reiterative transcription.Proceedings of the National Academy of Sciences.  101:10943-10948. 2004
2004 Novel oligosaccharide side chains of the collagen-like region of BclA, the major glycoprotein of the Bacillus anthracis exosporium.Journal of Biological Chemistry.  279:30945-30953. 2004
2004 Translocation of Escherichia coli RNA polymerase against a protein roadblock in vivo highlights a passive sliding mechanism for transcript elongation.Microbiological sciences.  51:1471-1481. 2004
2004 Interaction of modified liposomes with Bacillus spores.Chemical Communications.  430-431. 2004
2004 Surface layer protein EA1 is not a component of Bacillus anthracis spores but is a persistent contaminant in spore preparations.Journal of Bacteriology.  186:566-569. 2004
2003 Peptide ligands that bind selectively to spores of Bacillus subtilis and closely related species.Applied and Environmental Microbiology.  69:6841-6847. 2003
2003 Species-specific peptide ligands for the detection of Bacillus anthracis spores.Applied and Environmental Microbiology.  69:6288-6293. 2003
2003 Discovery of phage display peptide ligands for species-specific detection of Bacillus spores.Journal of Microbiological Methods.  53:263-271. 2003
2003 Identification of the immunodominant protein and other proteins of the Bacillus anthracis exosporium.Journal of Bacteriology.  185:1903-1910. 2003
2001 A long T. A tract in the upp initially transcribed region is required for regulation of upp expression by UTP-dependent reiterative transcription in Escherichia coli.Journal of Bacteriology.  183:221-228. 2001
1999 Multiple mechanisms are used for growth rate and stringent control of leuV transcriptional initiation in Escherichia coli.Journal of Bacteriology.  181:5771-5782. 1999
1998 Regulation of carAB expression in Escherichia coli occurs in part through UTP-sensitive reiterative transcription.Journal of Bacteriology.  180:705-713. 1998
1998 Erratum: Regulation of upp expression in escherichia coli by UTP- psensitive selection of transcriptional start sites coupled with UTP- dependent reiterative transcription (Journal of Bacteriology 17921 (6665- 6673))Journal of Bacteriology.  180:4991. 1998
1997 Transcription regulation by initiating NTP concentration: rRNA synthesis in bacteria.Science.  278:2092-2097. 1997
1997 Regulation of upp expression in Escherichia coli by UTP-sensitive selection of transcriptional start sites coupled with UTP-dependent reiterative transcription.Journal of Bacteriology.  179:6665-6673. 1997
1997 Erratum: Regulation of upp expression in Escherichia coli by UTP- sensitive selection of transcriptional start sites coupled with UTP-dependent reiterative transcription (Journal of Bacteriology 179:21 (6665-6673))Journal of Bacteriology.  179:7887. 1997
1996 In vitro assay for reiterative transcription during transcriptional initiation by Escherichia coli RNA polymerase.Methods in Enzymology.  273:71-85. 1996
1995 Regulation of codBA operon expression in Escherichia coli by UTP-dependent reiterative transcription and UTP-sensitive transcriptional start site switching.Journal of Molecular Biology.  254:552-565. 1995
1995 Rapid confirmation of single copy lambda prophage integration by PCRNucleic Acids Research.  23:1278. 1995
1994 Rapid confirmation of single copy lambda prophage integration by PCR.Nucleic Acids Research.  22:5765-5766. 1994
1994 Regulation of pyrBI operon expression in Escherichia coli by UTP-sensitive reiterative RNA synthesis during transcriptional initiation.Genes and Development.  8:2904-2912. 1994
1994 Nucleotide-specific transcriptional pausing in the pyrBI leader region of Escherichia coli K-12.Journal of Biological Chemistry.  269:18185-18191. 1994
1994 Effects of transcriptional start site sequence and position on nucleotide-sensitive selection of alternative start sites at the pyrC promoter in Escherichia coli.Journal of Bacteriology.  176:2938-2945. 1994
1994 Identification of the Shine-Dalgarno sequence required for expression and translational control of the pyrC gene in Escherichia coli K-12.Journal of Bacteriology.  176:2513-2516. 1994
1994 An Escherichia coli RNA polymerase defective in transcription due to its overproduction of abortive initiation products.Journal of Molecular Biology.  236:72-80. 1994
1993 Genetic evidence that promoter P2 is the physiologically significant promoter for the pyrBI operon of Escherichia coli K-12.Journal of Bacteriology.  175:2363-2369. 1993
1992 Translational control of pyrC expression mediated by nucleotide-sensitive selection of transcriptional start sites in Escherichia coli.Journal of Bacteriology.  174:514-524. 1992
1990 Characterization of transcriptional initiation from promoters P1 and P2 of the pyrBI operon of Escherichia coli K12.Journal of Biological Chemistry.  265:19091-19099. 1990
1990 Role of the purine repressor in the regulation of pyrimidine gene expression in Escherichia coli K-12.Journal of Bacteriology.  172:3208-3213. 1990
1989 Multiple control mechanisms for pyrimidine-mediated regulation of pyrBI operon expression in Escherichia coli K-12.Journal of Bacteriology.  171:3337-3342. 1989
1988 Role of the ribosome in suppressing transcriptional termination at the pyrBI attenuator of Escherichia coli K-12.Proceedings of the National Academy of Sciences.  85:7149-7153. 1988
1987 Nucleotide sequence and characterization of the pyrF operon of Escherichia coli K12.Journal of Biological Chemistry.  262:10239-10245. 1987
1987 Nucleotide sequence and expression of the pyrC gene of Escherichia coli K-12.Journal of Bacteriology.  169:3051-3058. 1987
1986 Genetic mapping of novel virulence determinants of Salmonella typhimurium to the region between trpD and supD.Microbial Pathogenesis.  1:115-124. 1986
1986 Salmonella typhimurium virulence genes necessary to exploit the Itys/s genotype of the mouse.Infection and Immunity.  51:872-878. 1986
1985 The ability of Salmonella typhimurium to produce the siderophore enterobactin is not a virulence factor in mouse typhoid.Infection and Immunity.  50:392-397. 1985
1985 Role of translation and attenuation in the control of pyrBI operon expression in Escherichia coli K-12.Journal of Bacteriology.  163:991-999. 1985
1985 Toxicity of the pyrimidine biosynthetic pathway intermediate carbamyl aspartate in Salmonella typhimurium.Journal of Bacteriology.  163:500-505. 1985
1983 Regulation of Escherichia coli aspartate transcarbamylase synthesis by guanosine tetraphosphate and pyrimidine ribonucleoside triphosphates.Journal of Bacteriology.  153:998-1007. 1983
1983 Attenuation control of pyrBI operon expression in Escherichia coli K-12.Proceedings of the National Academy of Sciences.  80:368-372. 1983
1981 Purification and properties of glutamine phosphoribosylpyrophosphate amidotransferase from Bacillus subtilis.Biochemistry.  20:5669-5674. 1981
1981 Infection of Salmonella typhimurium with coliphage Mu d1 (Apr lac): construction of pyr::lac gene fusions.Journal of Bacteriology.  145:299-305. 1981
1979 Pseudouridylation of tRNAs and its role in regulation in Salmonella typhimurium.Journal of Biological Chemistry.  254:5111-5119. 1979
1975 Oxygen-dependent inactivation of glutamine phosphoribosylpyrophosphate amidotransferase in stationary-phase cultures of Bacillus subtilis.Journal of Bacteriology.  121:108-114. 1975
1975 Oxygen-dependent inactivation of glutamine phosphoribosylpyrophosphate amidotransferase in vitro inactivation.Journal of Bacteriology.  121:115-120. 1975

Education And Training

  • Doctor of Philosophy in Biochemistry, University of Illinois System : Urbana-Champaign
  • Master of Sciences or Mathematics in Chemistry, University of Illinois System : Urbana-Champaign
  • Full Name

  • Charles Turnbough
  • Blazerid

  • chuckt