Selected Publications

Academic Article

Year Title Altmetric
2020 Neural coupling of intracranial pressure and aqueous humour outflow facility: A potential new therapeutic target for intraocular pressure management 2020
2020 A mesh-free approach to incorporate complex anisotropic and heterogeneous material properties into eye-specific finite element models 2020
2019 Cyclic Pattern of Intraocular Pressure (IOP) and Transient IOP Fluctuations in Nonhuman Primates Measured with Continuous Wireless Telemetry 2019
2019 Transient intraocular pressure fluctuations: Source, magnitude, frequency, and associated mechanical energy 2019
2019 Bayesian Semiparametric Functional Mixed Models for Serially Correlated Functional Data, With Application to Glaucoma Data 2019
2019 Effect of anesthesia on intraocular pressure measured with continuous wireless telemetry in nonhuman primates 2019
2019 The Magnitude of Intraocular Pressure Elevation Associated with Eye Rubbing 2019
2019 The relationship between scleral strain change and differential cumulative intraocular pressure exposure in the nonhuman primate chronic ocular hypertension model 2019
2018 A novel tree shrew (Tupaia belangeri) model of glaucoma 2018
2017 The magnitude and time course of IOP change in response to body position change in nonhuman primates measured using continuous IOP telemetry 2017
2017 Variation in the three-dimensional histomorphometry of the normal human optic nerve head with age and race: Lamina cribrosa and peripapillary scleral thickness and position 2017
2017 The Magnitude of Hypotony and Time Course of Intraocular Pressure Recovery Following Anterior Chamber Cannulation in Nonhuman Primates 2017
2017 Lamina cribrosa in glaucoma 2017
2016 Image-based quantification of fiber alignment within electrospun tissue engineering scaffolds is related to mechanical anisotropy 2016
2016 Nanofiber alignment regulates NIH3T3 cell orientation and cytoskeletal gene expression on electrospun PCL+gelatin nanofibers 2016
2015 High-magnitude and/or high-frequency mechanical strain promotes peripapillary scleral myofibroblast differentiation 2015
2015 Physical factors affecting outflow facility measurements in mice 2015
2015 IOP telemetry in the nonhuman primate 2015
2015 Optic nerve head biomechanics in aging and disease 2015
2015 Peripapillary choroidal thickness variation with age and race in normal eyes 2015
2015 Lamina cribrosa microarchitecture in normal monkey eyes part 1: Methods and initial results 2015
2015 Schiotz tonometry accurately measures intraocular pressure in Boston type 1 keratoprosthesis eyes 2015
2015 The Thrombospondin1-TGF-β Pathway and Glaucoma 2015
2014 The promise of prediction: Biomechanical analyses in neuro-ophthalmology 2014
2014 Variation of laminar depth in normal eyes with age and race 2014
2014 Human scleral structural stiffness increases more rapidly with age in donors of African descent compared to donors of European descent 2014
2014 Age-and race-related differences in human scleral material properties 2014
2014 The role of matricellular proteins in glaucoma 2014
2014 Age-related changes in human peripapillary scleral strain 2014
2014 Age-related differences in longitudinal structural change by spectral-domain optical coherence tomography in early experimental glaucoma 2014
2014 Material properties of the posterior human sclera 2014
2013 A forward incremental prestressing method with application to inverse parameter estimations and eye-specific simulations of posterior scleral shells 2013
2012 Intraocular pressure magnitude and variability as predictors of rates of structural change in non-human primate experimental glaucoma 2012
2012 Regional variations in mechanical strain in the posterior human sclera 2012
2012 Compensation method for obtaining accurate, sub-micrometer displacement measurements of immersed specimens using electronic speckle interferometry 2012
2012 Lamina cribrosa thickening in early glaucoma predicted by a microstructure motivated growth and remodeling approach 2012
2012 Perspectives on biomechanical growth and remodeling mechanisms in glaucoma 2012
2011 IOP-induced lamina cribrosa deformation and scleral canal expansion: Independent or related? 2011
2011 24-hour IOP telemetry in the nonhuman primate: implant system performance and initial characterization of IOP at multiple timescales. 2011
2011 Posterior (outward) migration of the lamina cribrosa and early cupping in monkey experimental glaucoma. 2011
2011 Glaucomatous cupping of the lamina cribrosa: A review of the evidence for active progressive remodeling as a mechanism 2011
2011 Biomechanical changes in the sclera of monkey eyes exposed to chronic IOP elevations. 2011
2011 IOP-induced lamina cribrosa displacement and scleral canal expansion: an analysis of factor interactions using parameterized eye-specific models. 2011
2011 Deformation of the early glaucomatous monkey optic nerve head connective tissue after acute IOP elevation in 3-D histomorphometric reconstructions 2011
2010 Changes in the biomechanical response of the optic nerve head in early experimental glaucoma. 2010
2010 Morphing methods to parameterize specimen-specific finite element model geometries 2010
2010 Correlation between local stress and strain and lamina cribrosa connective tissue volume fraction in normal monkey eyes 2010
2009 Comparison of clinical and three-dimensional histomorphometric optic disc margin anatomy 2009
2009 Deformation of the normal monkey optic nerve head connective tissue after acute IOP elevation within 3-D histomorphometric reconstructions 2009
2009 Impact of systemic blood pressure on the relationship between intraocular pressure and blood flow in the optic nerve head of nonhuman primates 2009
2009 The effect of acute intraocular pressure elevation on peripapillary retinal thickness, retinal nerve fiber layer thickness, and retardance 2009
2009 Scleral biomechanics in the aging monkey eye 2009
2009 Peripapillary and posterior scleral mechanics - Part I: Development of an anisotropic hyperelastic constitutive model 2009
2009 Peripapillary and posterior scleral mechanics - Part II: Experimental and inverse finite element characterization 2009
2009 Remodeling of the connective tissue microarchitecture of the lamina cribrosa in early experimental glaucoma 2009
2009 Detection of optic nerve head neural canal opening within histomorphometric and spectral domain optical coherence tomography data sets 2009
2009 Multiscale finite element modeling of the lamina cribrosa microarchitecture in the eye. 2009
2009 Physiologic intereye differences in monkey optic nerve head architecture and their relation to changes in early experimental glaucoma 2009
2008 Experimental surface strain mapping of porcine peripapillary sclera due to elevations of intraocular pressure 2008
2008 Experimental surface strain mapping of porcine peripapillary sclera due to elevations of intraocular pressure 2008
2008 Premise and prediction-how optic nerve head biomechanics underlies the susceptibility and clinical behavior of the aged optic nerve head 2008
2008 Mechanical Environment of the Optic Nerve Head in Glaucoma 2008
2007 3-D histomorphometry of the normal and early glaucomatous monkey optic nerve head: Prelaminar neural tissues and cupping 2007
2007 3-D histomorphometry of the normal and early glaucomatous monkey optic nerve head: Lamina cribrosa and peripapillary scleral position and thickness 2007
2007 Three-dimensional histomorphometry of the normal and early glaucomatous monkey optic nerve head: Neural canal and subarachnoid space architecture 2007
2007 Effects of storage time on the mechanical properties of rabbit peripapillary sclera after enucleation 2007
2006 A cellular solid model of the lamina cribrosa: Mechanical dependence on morphology 2006
2006 Segmentation of trabeculated structures using an anisotropic markov random field: Application to the study of the optic nerve head in glaucoma 2006
2005 Viscoelastic material properties of the peripapillary sclera in normal and early-glaucoma monkey eyes 2005
2005 The optic nerve head as a biomechanical structure: A new paradigm for understanding the role of IOP-related stress and strain in the pathophysiology of glaucomatous optic nerve head damage 2005
2004 Three-dimensional reconstruction of normal and early glaucoma monkey optic nerve head connective tissues 2004
2004 Tethered protein/peptide-surface-modified hydrogels 2004
2004 Time Scale for Periosteal Readhesion after Brow Lift 2004
2003 Anterior scleral canal geometry in pressurised (IOP 10) and non-pressurised (IOP 0) normal monkey eyes 2003
2003 Deformation of the lamina cribrosa and anterior scleral canal wall in early experimental glaucoma 2003
2003 Viscoelastic characterization of peripapillary sclera: Material properties by quadrant in rabbit and monkey eyes 2003
2002 Peripapillary scleral thickness in perfusion-fixed normal monkey eyes 2002
2002 Periosteal readhesion after brow-lift in New Zealand white rabbits. 2002
2001 Posterior scierai thickness in perfusion-fixed normal and early-glaucoma monkey eyes 2001


Year Title Altmetric
2016 Glaucoma and structure-based mechanics of the lamina cribrosa at multiple scales.  93-122. 2016
2015 Mechanical Strain and Restructuring of the Optic Nerve Head.  67-87. 2015
2010 Biomechanical changes of the optic disc.  153-164. 2010
2010 Clinical cupping: Laminar and prelaminar components.  185-194. 2010

Education And Training

  • Doctor of Philosophy in Biomedical / Medical Engineering, Tulane University 2002
  • Full Name

  • J. Crawford Downs