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McNicholas-Bevensee, Carmel
Associate Professor
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E-mail
cbevense@uab.edu
Office Address
MCLM 558
CHARLES A. MCCALLUM BASIC HEALTH SCIENCES EDU AND RESEARCH BLDG
Birmingham, AL 35294-0005
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Map of Science
Co-investigator Network
McNicholas-Bevensee, Carmel
Associate Professor
Positions
Scholar (C)
,
Center for Clinical and Translational Science (CCTS)
,
General Clinical Research Center
2010 -
Associate Professor (P)
,
Cell, Developmental and Integrative Biology (CDIB)
,
Academic Joint Departments
2012 -
Associate Scientist (C)
,
Cystic Fibrosis Research Center
,
School of Medicine
2013 -
Publications
Research
Teaching
Background
Contact
Publications
Selected Publications
Academic Article
Filter
Year
Title
Altmetric
2019
Activated PMN Exosomes: Pathogenic Entities Causing Matrix Destruction and Disease in the Lung.
.
Cell
. 176:113-126.e15.
2019
2017
Beyond cystic fibrosis transmembrane conductance regulator (CFTR) single channel kinetics: implications for therapeutic intervention.
.
Journal of Physiology
. 595:1015-1016.
2017
2016
Analysis of cystic fibrosis-associated P67L CFTR illustrates barriers to personalized therapeutics for orphan diseases.
.
JCI insight
. 1.
2016
2016
The Cystic Fibrosis Transmembrane Conductance Regulator Potentiator Ivacaftor Augments Mucociliary Clearance Abrogating Cystic Fibrosis Transmembrane Conductance Regulator Inhibition by Cigarette Smoke.
.
American Journal of Respiratory Cell and Molecular Biology
. 56:99-108.
2016
2016
Expression and purification of the alpha subunit of the epithelial sodium channel, ENaC.
.
Protein Expression and Purification
. 117:67-75.
2016
2015
Physical and functional interactions between a glioma cation channel and integrin-β1 require α-actinin.
.
American Journal of Physiology - Cell Physiology
. 309:C308-C319.
2015
2014
An aberrant leukotriene A4 hydrolase-proline-glycine-proline pathway in the pathogenesis of chronic obstructive pulmonary disease.
.
American Journal of Respiratory and Critical Care Medicine
. 190:51-61.
2014
2014
Cystic fibrosis transmembrane conductance regulator activation by roflumilast contributes to therapeutic benefit in chronic bronchitis.
.
American Journal of Respiratory Cell and Molecular Biology
. 50:549-558.
2014
2014
Erratum: Resveratrol Enhances Airway Surface Liquid Depth in Sinonasal Epithelium by Increasing Cystic Fibrosis Transmembrane Conductance Regulator Open Probability (PLoS ONE (2014) 9:1 (DOI:10.1371/annotation/d852ff1d-2824- 4f4d-80f2-9be7a42a5f25))
.
PLoS ONE
. 9.
2014
2014
Sinupret activates CFTR and TMEM16A-dependent transepithelial chloride transport and improves indicators of mucociliary clearance.
.
PLoS ONE
. 9:e104090.
2014
2013
Cigarette smoke induces systemic defects in cystic fibrosis transmembrane conductance regulator function
.
American Journal of Respiratory and Critical Care Medicine
. 188:1321-1330.
2013
2013
Cigarette smoke induces systemic defects in cystic fibrosis transmembrane conductance regulator function.
.
American Journal of Respiratory and Critical Care Medicine
. 188:1321-1330.
2013
2013
IL-8 inhibits cAMP-stimulated alveolar epithelial fluid transport via a GRK2/PI3K-dependent mechanism.
.
Federation proceedings
. 27:1095-1106.
2013
2013
Resveratrol enhances airway surface liquid depth in sinonasal epithelium by increasing cystic fibrosis transmembrane conductance regulator open probability.
.
PLoS ONE
. 8:e81589.
2013
2012
Glioma-specific cation conductance regulates migration and cell cycle progression.
.
Journal of Biological Chemistry
. 287:4053-4065.
2012
2011
Interaction of ASIC1 and ENaC subunits in human glioma cells and rat astrocytes.
.
American Journal of Physiology - Cell Physiology
. 300:C1246-C1259.
2011
2009
Mammalian target of rapamycin: MasTOR mediator of cellular changes in pathological states?
.
Hypertension
. 54:1221-1222.
2009
2009
Phosphatidylinositol 4,5-bisphosphate (PIP2) stimulates the electrogenic Na/HCO3 cotransporter NBCe1-A expressed in Xenopus oocytes.
.
Proceedings of the National Academy of Sciences
. 106:14150-14155.
2009
2006
Activation of gadolinium-sensitive ion channels in cardiomyocytes in early adaptive stages of volume overload-induced heart failure.
.
Cardiovascular Research
. 72:262-270.
2006
2006
Electrogenic Na/HCO3 cotransporter (NBCe1) variants expressed in Xenopus oocytes: functional comparison and roles of the amino and carboxy termini.
.
Journal of General Physiology
. 127:639-658.
2006
2006
Reactive species mediate inhibition of alveolar type II sodium transport during mycoplasma infection.
.
American Journal of Respiratory and Critical Care Medicine
. 173:334-344.
2006
2004
Regulation of amiloride-sensitive Na(+) transport by basal nitric oxide.
.
American Journal of Respiratory Cell and Molecular Biology
. 30:720-728.
2004
2002
Ablation of internalization signals in the carboxyl-terminal tail of the cystic fibrosis transmembrane conductance regulator enhances cell surface expression.
.
Journal of Biological Chemistry
. 277:49952-49957.
2002
1998
pH-dependent modulation of the cloned renal K+ channel, ROMK
.
AJP - Renal Physiology
. 275.
1998
1998
pH-dependent modulation of the cloned renal K+ channel, ROMK.
.
American Journal of Physiology
. 275:F972-F981.
1998
1998
Partially active channels produced by PKA site mutation of the cloned renal K+ channel, ROMK2 (kir1.2).
.
American Journal of Physiology
. 275:F415-F422.
1998
1998
Partially active channels produced by PKA site mutation of the cloned renal K
+
channel, ROMK2 (kir1.2)
.
AJP - Renal Physiology
. 275.
1998
1997
A functional CFTR-NBF1 is required for ROMK2-CFTR interaction
.
AJP - Renal Physiology
. 273.
1997
1997
A functional CFTR-NBF1 is required for ROMK2-CFTR interaction.
.
American Journal of Physiology
. 273:F843-F848.
1997
1997
Diversity of channels generated by different combinations of epithelial sodium channel subunits.
.
Journal of General Physiology
. 109:681-692.
1997
1996
Molecular site for nucleotide binding on an ATP-sensitive renal K
+
channel (ROMK2)
.
American Journal of Physiology
. 271.
1996
1996
Molecular site for nucleotide binding on an ATP-sensitive renal K+ channel (ROMK2).
.
American Journal of Physiology
. 271:F275-F285.
1996
1996
Sensitivity of a renal K+ channel (ROMK2) to the inhibitory sulfonylurea compound glibenclamide is enhanced by coexpression with the ATP-binding cassette transporter cystic fibrosis transmembrane regulator.
.
Proceedings of the National Academy of Sciences
. 93:8083-8088.
1996
1995
Primary structure and functional expression of a cGMP-gated potassium channel.
.
Proceedings of the National Academy of Sciences
. 92:11711-11715.
1995
1995
Regulation of ATP-sensitive K
+
channel by membrane-bound protein phosphatases in rat principal tubule cell
.
AJP - Renal Physiology
. 269.
1995
1995
Regulation of ATP-sensitive K+ channel by membrane-bound protein phosphatases in rat principal tubule cell.
.
American Journal of Physiology
. 269:F355-F362.
1995
1995
Role of Ca
2+
/CaMK II in Ca
2+
-induced K
+
channel inhibition in rat CCD principal cell
.
AJP - Renal Physiology
. 268.
1995
1995
Role of Ca2+/CaMK II in Ca(2+)-induced K+ channel inhibition in rat CCD principal cell.
.
American Journal of Physiology
. 268:F211-F219.
1995
1994
Na-K-Cl cotransport in villus and crypt cells from rat duodenum
.
American Journal of Physiology
. 267.
1994
1994
Na-K-Cl cotransport in villus and crypt cells from rat duodenum
.
AJP - Gastrointestinal and Liver Physiology
. 267.
1994
1994
Na-K-Cl cotransport in villus and crypt cells from rat duodenum.
.
American Journal of Physiology
. 267:G1004-G1011.
1994
1994
Regulation of ROMK1 K+ channel activity involves phosphorylation processes.
.
Proceedings of the National Academy of Sciences
. 91:8077-8081.
1994
1994
A novel approach allows identification of K channels in the lateral membrane of rat CCD
.
AJP - Renal Physiology
. 266.
1994
1994
Properties and regulation of basolateral K+ channels in rat duodenal crypts.
.
Journal of Physiology
. 477 ( Pt 3):381-392.
1994
1994
A novel approach allows identification of K channels in the lateral membrane of rat CCD.
.
American Journal of Physiology
. 266:F813-F822.
1994
1994
Aldosterone-induced apical Na+ and K+ conductances are located predominantly in surface cells in rat distal colon
.
American Journal of Physiology
. 266.
1994
1994
A novel approach allows identification of K channels in the lateral membrane of rat CCD
.
American Journal of Physiology
. 266.
1994
1994
Aldosterone-induced apical Na+ and K+ conductances are located predominantly in surface cells in rat distal colon
.
American Journal of Physiology
. 266.
1994
1994
Aldosterone-induced apical Na+ and K+ conductances are located predominantly in surface cells in rat distal colon.
.
American Journal of Physiology
. 266:G71-G82.
1994
1994
Potassium channels in colonic crypts.
.
Lancet
. 343:23-25.
1994
1992
A Cl- conductance sensitive to external pH in the apical membrane of rat duodenal enterocytes.
.
Journal of Physiology
. 456:519-528.
1992
Research
Principal Investigator On
Sweat Gland Culture Techniques for the Study of Cystic Fibrosis
awarded by
Cystic Fibrosis Foundation
2015 - 2018
Nurturing Interest in Biomedical Science Education Among Elementary Students
awarded by
American Society for Biochemistry and Molecular Biology
2012 - 2013
Investigator On
UAB CF Research and Translation Core Center
awarded by
National Institute of Diabetes and Digestive and Kidney Diseases/NIH/DHHS
2015 - 2018
UAB CF Research and Translation Core Center - Core A: Cell Model and Assay Core
awarded by
National Institute of Diabetes and Digestive and Kidney Diseases/NIH/DHHS
2015 - 2018
Inter-Professional Summer Training and Enrichment Program in Health Care (l-STEP in Health Care)
awarded by
Johnson (Robert Wood) Foundation
2016 - 2017
Simulation Infrastructure Expansion for Preclinical Health Professions Students
awarded by
UNIVERSITY OF ALABAMA HEALTH SERVICES FOUNDATION
2013 - 2016
Sodium Entry into Amiloride-Sensitive Epithelia
awarded by
National Institute of Diabetes and Digestive and Kidney Diseases/NIH/DHHS
2010 - 2016
UAB CF Research and Translation Core Center
awarded by
National Institute of Diabetes and Digestive and Kidney Diseases/NIH/DHHS
2012 - 2016
UAB CF Research and Translation Core Center - Core A
awarded by
National Institute of Diabetes and Digestive and Kidney Diseases/NIH/DHHS
2012 - 2016
Teaching
Teaching Activities
BHS610 - Clin Application & Simulation (Spring Term 2019)
2019
GBS751 - Heart Lung & Kidney (Spring Term 2019)
2019
BHS555 - Integrated Systs II: Cardiopul (Fall Term 2018)
2018
BHS610 - Clin Application & Simulation (Spring Term 2018)
2018
GBS751 - HEART, LUNG & KIDNEY - MODULE 2 (Spring Term 2018)
2018
BHS555 - Integrated Systs II: Cardiopul (Fall Term 2017)
2017
BHS610 - Clin Application & Simulation (Spring Term 2017)
2017
BHS555 - Integrated Systs II: Cardiopul (Fall Term 2016)
2016
BHS610 - Clin Application & Simulation (Spring Term 2016)
2016
GBS751 - Heart Lung & Kidney (Spring Term 2016)
2016
GBS751 - HEART, LUNG & KIDNEY - MODULE 2 (Spring Term 2016)
2016
BHS555 - Integrated Systs II: Cardiopul (Fall Term 2015)
2015
GBS751 - Heart Lung & Kidney (Spring Term 2015)
2015
GBS751 - HEART, LUNG & KIDNEY - MODULE 2 (Spring Term 2015)
2015
GBS751 - Heart Lung & Kidney (Spring Term 2014)
2014
GBS751 - Heart Lung & Kidney (Spring Term 2013)
2013
GBS751 - HEART, LUNG & KIDNEY - MODULE 2 (Spring Term 2013)
2013
GBS751 - Heart Lung & Kidney (Spring Term 2012)
2012
OBHS111 - Fundamentals of Dent and Opt I (Fall Term 2011)
2011
OBHS111 - Fundamentals of Dent and Opt I (Fall Term 2010)
2010
OBHS111 - Fundamentals of Dent and Opt I (Fall Term 2009)
2009
OBHS111 - Fundamentals of Dent and Opt I (Fall Term 2008)
2008
Background
Education And Training
Doctor of Philosophy in Cell Physiology,
The University of Manchester
Contact
Full Name
Carmel
McNicholas-Bevensee