Positions

Overview

  • Julienne L. Carstens, Ph.D., is an investigator whose research is focused on understanding tumor biology with the goal of developing translational targets for pancreatic cancer. Her publications in top-tier journals highlight her work related to the fibrotic and immune tumor microenvironment and metastatic progression of cancer. She was recruited jointly by the Division of Hematology and Oncology and the O’Neal Comprehensive Cancer Center. Her lab space is in the Wallace Tumor Institute.
    Dr. Carstens trained at MD Anderson Cancer Center in Houston, Texas, where she completed her postdoctoral fellowship in Raghu Kalluri, M.D., Ph.D.’s lab in the Department of Cancer Biology.

    • Selected Publications

    Academic Article

    Year Title Altmetric
    2022 Identification of Functional Heterogeneity of Carcinoma-Associated Fibroblasts with Distinct IL-6 Mediated Therapy Resistance in Pancreatic Cancer..  Cancer Discovery.  2022
    2021 Stabilized epithelial phenotype of cancer cells in primary tumors leads to increased colonization of liver metastasis in pancreatic cancer.  Cell Reports.  35. 2021
    2018 BMP7 signaling in TGFBR2-deficient stromal cells provokes epithelial carcinogenesis 2018
    2018 Dual reporter genetic mouse models of pancreatic cancer identify an epithelial-to-mesenchymal transition-independent metastasis program.  EMBO Molecular Medicine.  10. 2018
    2017 Morphologically constrained spectral unmixing by dictionary learning for multiplex fluorescence microscopy..  Bioinformatics.  33:2182-2190. 2017
    2017 Low-dose hydralazine prevents fibrosis in a murine model of acute kidney injury–to–chronic kidney disease progression.  Kidney International.  91:157-176. 2017
    2017 Spatial computation of intratumoral T cells correlates with survival of patients with pancreatic cancer.  Nature Communications.  8. 2017
    2015 Erratum to Depletion of Carcinoma-Associated Fibroblasts and Fibrosis Induces Immunosuppression and Accelerates Pancreas Cancer with Reduced Survival [Cancer Cell 25, 719-734; (2014)].  Cancer Cell.  28:831-833. 2015
    2015 Epithelial-to-mesenchymal transition is dispensable for metastasis but induces chemoresistance in pancreatic cancer.  Nature.  527:525-530. 2015
    2015 Epithelial-to-mesenchymal transition induces cell cycle arrest and parenchymal damage in renal fibrosis.  Nature Medicine.  21:998-1009. 2015
    2014 Depletion of carcinoma-associated fibroblasts and fibrosis induces immunosuppression and accelerates pancreas cancer with reduced survival.  Cancer Cell.  25:719-734. 2014
    2014 Microenvironment-dependent cues trigger miRNA-regulated feedback loop to facilitate the EMT/MET switch.  Journal of Clinical Investigation.  124:1458-1460. 2014
    2014 FGFR1-WNT-TGF-β signaling in prostate cancer mouse models recapitulates human reactive stroma.  Cancer Research.  74:609-620. 2014
    2012 Activation of Wnt signaling by chemically induced dimerization of LRP5 disrupts cellular homeostasis.  PLoS ONE.  7. 2012

    Education And Training

  • MD Anderson Cancer Center Cancer Biology, Postdoctoral Fellowship
  • Doctor of Philosophy in Cell / Cellular and Molecular Biology, Baylor University 2013
  • Bachelor of Science or Mathematics in Cell / Cellular and Molecular Biology, Louisiana Tech University 2007

    • Full Name

  • Julienne Carstens