Positions

Overview

  • Dr. Bradley K. Yoder, Professor , completed his undergraduate studies in biochemistry and molecular biology at the University of Maryland Baltimore County (B.S. 1988), and received a Ph.D. in molecular and cellular biology from the University of Maryland in 1993. His postdoctoral studies were performed at Oak Ridge National Laboratory under the guidance of Dr. Rick Woychik where Dr. Yoder was an Alexander Hollaender Distinguished Postdoctoral Fellow. His research over the past two decades has focused on the cellular and molecular mechanisms regulating assembly, maintenance, and function of the primary cilium utilizing complementary approaches in mice, C. elegans, and in cell culture models. Work from his laboratory has utilized genetic screens in C. elegans to identify proteins required for ciliogenesis and cilia mediated signaling activities and how these genes function in pathways (e.g. Daf-2 Insulin/IGF-like pathway) that regulate life span and energy homeostasis. His group has analyzed in mammalian systems how the cilium regulates important developmental pathways and how loss of the cilium causes abnormalities in left-right body axis specification, limb and tooth patterning, skin and hair follicle morphogenesis, and impairs endochondrial bone formation. His group is also providing important fundamental insights into the connection between ciliary dysfunction and cystic kidney disorders, and novel roles for neuronal cilia in the regulation of satiation responses, disruption of which causes obesity and type II diabetes.
  • Selected Publications

    Academic Article

    Year Title Altmetric
    2019 Heterozygous Pkhd1 C642* mice develop cystic liver disease and proximal tubule ectasia that mimics radiographic signs of medullary sponge kidneyAJP - Renal Physiology.  316:F463-F472. 2019
    2019 Truncating PKHD1 and PKD2 mutations alter energy metabolismAJP - Renal Physiology.  316:F414-F425. 2019
    2019 Mks6 mutations reveal tissue-and cell type-specific roles for the cilia transition zoneFederation proceedings.  33:1440-1455. 2019
    2019 Urinary T cells correlate with rate of renal function loss in autosomal dominant polycystic kidney diseasePhysiological Reports.  7. 2019
    2018 Role for intraflagellar transport in building a functional transition zoneEMBO Reports.  19. 2018
    2018 Primary cilia disruption differentially affects the infiltrating and resident macrophage compartment in the liverAJP - Gastrointestinal and Liver Physiology.  314:G677-G689. 2018
    2018 Ectopic Phosphorylated Creb Marks Dedifferentiated Proximal Tubules in Cystic Kidney DiseaseAmerican Journal of Pathology.  188:84-94. 2018
    2016 Mutation of Growth Arrest Specific 8 Reveals a Role in Motile Cilia Function and Human DiseasePLoS Genetics.  12. 2016
    2016 The tumor-associated glycosyltransferase ST6Gal-I regulates stem cell transcription factors and confers a cancer stem cell phenotypeCancer Research.  76:3978-3988. 2016
    2016 Coiled-coil domain containing 42 (Ccdc42) is necessary for proper sperm development and male fertility in the mouseDevelopmental Biology.  412:208-218. 2016
    2016 A Screen for Modifiers of Cilia Phenotypes Reveals Novel MKS Alleles and Uncovers a Specific Genetic Interaction between osm-3 and nphp-4PLoS Genetics.  12. 2016
    2016 Non-essential role for cilia in coordinating precise alignment of lens fibresMechanisms of Development.  139:10-17. 2016
    2015 KIAA0556 is a novel ciliary basal body component mutated in Joubert syndromeGenome Biology.  16. 2015
    2015 Genetic and informatic analyses implicate Kif12 as a candidate gene within the Mpkd2 locus that modulates renal cystic disease severity in the Cys1cpk mousePLoS ONE.  10. 2015
    2015 Heterotrimeric Kinesin-2 (KIF3) mediates transition zone and axoneme formation of mouse photoreceptorsJournal of Biological Chemistry.  290:12765-12778. 2015
    2015 Snap Shot: Sensing and signaling by ciliaCell.  161:692-692.e1. 2015
    2014 High-throughput genome editing and phenotyping facilitated by high resolution melting curve analysisPLoS ONE.  9. 2014
    2014 Complement C3 activation in cyst fluid and urine from autosomal dominant polycystic kidney disease patientsJournal of Internal Medicine.  276:539-540. 2014
    2014 Hippocampal and cortical primary cilia are required for aversive memory in micePLoS ONE.  9. 2014
    2014 Primary cilia enhance kisspeptin receptor signaling on gonadotropin- releasing hormone neuronsProceedings of the National Academy of Sciences.  111:10335-10340. 2014
    2014 Aberrant expression of laminin-332 promotes cell proliferation and cyst growth in ARPKDAJP - Renal Physiology.  306. 2014
    2014 Deletion of airway cilia results in noninflammatory bronchiectasis and hyperreactive airwaysAJP - Lung Cellular and Molecular Physiology.  306. 2014
    2014 Monitoring endosomal trafficking of the g protein-coupled receptor somatostatin receptor 3Methods in Enzymology.  534:261-280. 2014
    2013 An inducible CiliaGFP mouse model for in vivo visualization and analysis of cilia in live tissueCilia.  2. 2013
    2013 Leptin resistance is a secondary consequence of the obesity in ciliopathy mutant miceProceedings of the National Academy of Sciences.  110:7796-7801. 2013
    2013 Quantitative Peptidomics of Purkinje Cell Degeneration MicePLoS ONE.  8. 2013
    2013 Proximal tubule proliferation is insufficient to induce rapid cyst formation after cilia disruptionJournal of the American Society of Nephrology.  24:456-464. 2013
    2013 Microtubule modifications and stability are altered by cilia perturbation and in cystic kidney diseaseCytoskeleton.  70:24-31. 2013
    2012 Mammalian Clusterin associated protein 1 is an evolutionarily conserved protein required for ciliogenesisCilia.  1. 2012
    2012 Gene therapy rescues cilia defects and restores olfactory function in a mammalian ciliopathy modelNature Medicine.  18:1423-1428. 2012
    2012 Kidney injury accelerates cystogenesis via pathways modulated by heme oxygenase and complementJournal of the American Society of Nephrology.  23:1161-1171. 2012
    2012 Increased Na+/H+ exchanger activity on the apical surface of a cilium-deficient cortical collecting duct principal cell model of polycystic kidney diseaseAmerican Journal of Physiology - Cell Physiology.  302. 2012
    2011 Assessing the pathogenic potential of human nephronophthisis disease-associated NPHP-4 missense mutations in C. elegansHuman Molecular Genetics.  20:2942-2954. 2011
    2011 Loss of primary cilia upregulates renal hypertrophic signaling and promotes cystogenesisJournal of the American Society of Nephrology.  22:839-848. 2011
    2011 Role of epidermal primary cilia in the homeostasis of skin and hair folliclesDevelopment.  138:1675-1685. 2011
    2011 Lack of primary cilia primes shear-induced endothelial-to-mesenchymal transitionCirculation Research.  108:1093-1101. 2011
    2011 MKS and NPHP modules cooperate to establish basal body/transition zone membrane associations and ciliary gate function during ciliogenesisJournal of Cell Biology.  192:1023-1041. 2011
    2011 Soluble levels of cytosolic tubulin regulate ciliary length controlCell regulation.  22:806-816. 2011
    2011 GMAP210 and IFT88 are present in the spermatid golgi apparatus and participate in the development of the acrosome-acroplaxome complex, head-tail coupling apparatus and tailDevelopmental Dynamics.  240:723-736. 2011
    2011 Erratum: In vivo fate mapping and expression analysis reveals molecular hallmarks of prospectively isolated adult neural stem cells (Cell Stem Cell (2010) 7 (744-758))Cell Stem Cell.  8:119. 2011
    2011 Mutations in Traf3ip1 reveal defects in ciliogenesis, embryonic development, and altered cell size regulationDevelopmental Biology.  360:66-76. 2011
    2010 In vivo fate mapping and expression analysis reveals molecular hallmarks of prospectively isolated adult neural stem cellsCell Stem Cell.  7:744-758. 2010
    2010 The zebrafish foxj1a transcription factor regulates cilia function in response to injury and epithelial stretchProceedings of the National Academy of Sciences.  107:18499-18504. 2010
    2010 Normal ciliogenesis requires synergy between the cystic kidney disease genes MKS-3 and NPHP-4Journal of the American Society of Nephrology.  21:782-793. 2010
    2010 Directional cell migration and chemotaxis in wound healing response to PDGF-AA are coordinated by the primary cilium in fibroblastsCellular Physiology and Biochemistry.  25:279-292. 2010
    2009 Generating conditional mutants to analyze ciliary functions: the use of Cre-lox technology to disrupt cilia in specific organs.Methods in Cell Biology.  93:305-330. 2009
    2009 The primary cilium coordinates early cardiogenesis and hedgehog signaling in cardiomyocyte differentiationJournal of Cell Science.  122:3070-3082. 2009
    2009 The Primary Cilium as a Complex Signaling CenterCurrent Biology.  19. 2009
    2009 Primary cilia regulate Shh activity in the control of molar tooth numberDevelopment.  136:897-903. 2009
    2009 Primary cilia and signaling pathways in mammalian development, health and diseaseNephron.  111. 2009
    2009 An essential role for dermal primary cilia in hair follicle morphogenesisJournal of Investigative Dermatology.  129:438-448. 2009
    2009 Utilization of conditional alleles to study the role of the primary cilium in obesity.Methods in Cell Biology.  94:162-179. 2009
    2008 Chapter 13 Ciliary Dysfunction in Developmental Abnormalities and DiseasesCurrent Topics in Developmental Biology.  85:371-427. 2008
    2008 PrefaceCurrent Topics in Developmental Biology.  85. 2008
    2008 Characterization of primary cilia and hedgehog signaling during development of the human pancreas and in human pancreatic duct cancer cell linesDevelopmental Dynamics.  237:2039-2052. 2008
    2008 Role for primary cilia in the regulation of mouse ovarian functionDevelopmental Dynamics.  237:2053-2060. 2008
    2008 The Oak Ridge Polycystic Kidney mouse: Modeling ciliopathies of mice and menDevelopmental Dynamics.  237:1960-1971. 2008
    2008 Loss of apical monocilia on collecting duct principal cells impairs ATP secretion across the apical cell surface and ATP-dependent and flow-induced calcium signalsPurinergic Signalling.  4:155-170. 2008
    2008 Functional redundancy of the B9 proteins and nephrocystins in Caenorhabditis elegans ciliogenesisCell regulation.  19:2154-2168. 2008
    2008 THM1 negatively modulates mouse sonic hedgehog signal transduction and affects retrograde intraflagellar transport in ciliaNature Genetics.  40:403-410. 2008
    2008 Ciliary proteins link basal body polarization to planar cell polarity regulationNature Genetics.  40:69-77. 2008
    2007 Disruption of Intraflagellar Transport in Adult Mice Leads to Obesity and Slow-Onset Cystic Kidney DiseaseCurrent Biology.  17:1586-1594. 2007
    2007 Cilia proteins control cerebellar morphogenesis by promoting expansion of the granule progenitor poolJournal of Neuroscience.  27:9780-9789. 2007
    2007 Articular cartilage and growth plate defects are associated with chondrocyte cytoskeletal abnormalities in Tg737orpk mice lacking the primary cilia protein polarisCollagen and related research.  26:234-246. 2007
    2007 Development of the post-natal growth plate requires intraflagellar transport proteinsDevelopmental Biology.  305:202-216. 2007
    2007 Role of primary cilia in the pathogenesis of polycystic kidney diseaseJournal of the American Society of Nephrology.  18:1381-1388. 2007
    2007 Sensory ciliogenesis in Caenorhabditis elegans: Assignment of IFT components into distinct modules based on transport and phenotypic profilesCell regulation.  18:1554-1569. 2007
    2007 Altered pHi regulation and Na+/HCO-3 transporter activity in choroid plexus of cilia-defective Tg737orpk mutant mouseAmerican Journal of Physiology - Cell Physiology.  292. 2007
    2007 Intraflagellar transport is essential for endochondral bone formationDevelopment.  134:307-316. 2007
    2006 Caenorhabditis elegans DYF-2, an orthologue of human WDR19, is a component of the intraflagellar transport machinery in sensory ciliaCell regulation.  17:4801-4811. 2006
    2006 IFTA-2 is a conserved cilia protein involved in pathways regulating longevity dauer formation in Caenorhabditis elegansJournal of Cell Science.  119:4088-4100. 2006
    2006 The primary cilium in cell signaling and cancerCancer Research.  66:6463-6467. 2006
    2006 Loss of primary cilia results in deregulated and unabated apical calcium entry in ARPKD collecting duct cellsAJP - Renal Physiology.  290. 2006
    2006 More Than Just the Postal Service: Novel Roles for IFT Proteins in Signal TransductionDevelopmental Cell.  10:541-542. 2006
    2006 Heightened epithelial Na+ channel-mediated Na+ absorption in a murine polycystic kidney disease model epithelium lacking apical monociliaAmerican Journal of Physiology - Cell Physiology.  290. 2006
    2006 Molecular pathogenesis of autosomal dominant polycystic kidney diseaseExpert Reviews in Molecular Medicine.  8:1-22. 2006
    2005 An incredible decade for the primary cilium: A look at a once-forgotten organelleAJP - Renal Physiology.  289. 2005
    2005 Dysfunctional cilia lead to altered ependyma and choroid plexus function, and result in the formation of hydrocephalusDevelopment.  132:5329-5339. 2005
    2005 The C. elegans homologs of nephrocystin-1 and nephrocystin-4 are cilia transition zone proteins involved in chemosensory perceptionJournal of Cell Science.  118:5575-5587. 2005
    2005 Mechanoregulation of intracellular Ca2+ concentration is attenuated in collecting duct of monocilium-impaired orpk miceAJP - Renal Physiology.  289. 2005
    2005 Gli2 and Gli3 localize to cilia and require the intraflagellar transport protein polaris for processing and function.PLoS Genetics.  1. 2005
    2005 Cilia-driven fluid flow in the zebrafish pronephros, brain and Kupffer's vesicle is required for normal organogenesisDevelopment.  132:1907-1921. 2005
    2005 Disruption of IFT results in both exocrine and endocrine abnormalities in the pancreas of Tg737orpk mutant miceLaboratory Investigation.  85:45-64. 2005
    2005 Gli2 and Gli3 localize to cilia and require the intraflagellar transport protein polaris for processing and functionPLoS Genetics.  1:0480-0488. 2005
    2004 Cystic kidney diseases: All roads lead to the ciliumNews in Physiological Sciences.  19:225-230. 2004
    2004 Comparative genomics identifies a flagellar and basal body proteome that includes the BBS5 human disease geneCell.  117:541-552. 2004
    2003 A novel dynein light intermediate chain colocalizes with the retrograde motor for intraflagellar transport at sites of axoneme assembly in Chlamydomonas and mammalian cellsCell regulation.  14:2041-2056. 2003
    2003 Loss of the Tg737 protein results in skeletal patterning defectsDevelopmental Dynamics.  227:78-90. 2003
    2003 XBX-1 encodes a dynein light intermediate chain required for retrograde intraflagellar transport and cilia assembly in Caenorhabditis elegansCell regulation.  14:2057-2070. 2003
    2003 Identification of CHE-13, a novel intraflagellar transport protein required for cilia formationExperimental Cell Research.  284:249-261. 2003
    2002 Comparative gene expression profile analysis of GLI and c-MYC in an epithelial model of malignant transformationCancer Research.  62:5867-5873. 2002
    2002 The polycystic kidney disease proteins, polycystin-1, polycystin-2, polaris, and cystin, are co-localized in renal ciliaJournal of the American Society of Nephrology.  13:2508-2516. 2002
    2002 Polaris, a protein disrupted in orpk mutant mice, is required for assembly of renal ciliumAJP - Renal Physiology.  282. 2002
    2002 Polaris, a protein disrupted in orpk mutant mice, is required for assembly of renal cilium.AJP - Renal Physiology.  282:F541-F552. 2002
    2002 Cystin, a novel cilia-associated protein, is disrupted in the cpk mouse model of polycystic kidney disease.Journal of Clinical Investigation.  109:533-540. 2002
    2002 Cystin, a novel cilia-associated protein, is disrupted in the cpk mouse model of polycystic kidney diseaseJournal of Clinical Investigation.  109:533-540. 2002
    2001 The C. elegans homolog of the murine cystic kidney disease gene Tg737 functions in a ciliogenic pathway and is disrupted in osm-5 mutant wormsDevelopment.  128:1493-1505. 2001
    2001 Jets: A modification to speed flexible oligonucleotide array constructionPharmacogenomics Journal.  1:163-165. 2001
    2001 Polaris, a protein involved in left-right axis patterning, localizes to basal bodies and ciliaCell regulation.  12:589-599. 2001
    2000 The Oak Ridge Polycystic Kidney (orpk) disease gene is required for left-right axis determinationDevelopment.  127:2347-2355. 2000
    1998 Epidermal growth factor receptor activity mediates renal cyst formation in polycystic kidney diseaseJournal of Clinical Investigation.  101:935-939. 1998
    1998 Characterization of growth factor responsiveness and alterations in growth factor homeostasis involved in the tumorigenic conversion of mouse oval cellsGrowth Factors.  15:81-94. 1998
    1997 The combination of epidermal growth factor and transforming growth factor-β induces novel phenotypic changes in mouse liver stem cell linesJournal of Cell Science.  110:3117-3129. 1997
    1997 Differential rescue of the renal and hepatic disease in an autosomal recessive polycystic kidney disease mouse mutant: A new model to study the liver lesionAmerican Journal of Pathology.  150:2231-2241. 1997
    1997 Isolation and characterization of liver epithelial cell lines from wild- type and mutant TgN737Rpw miceAmerican Journal of Pathology.  150:1189-1197. 1997
    1997 The tetratricopeptide repeat containing Tg737 gene is a liver neoplasia tumor suppressor geneOncogene.  15:1797-1803. 1997
    1996 Oval cell proliferation associated with the murine insertional mutation TgN737RpwAmerican Journal of Pathology.  149:1919-1930. 1996
    1996 Functional correction of renal defects in a mouse model for ARPKD through expression of the cloned wild-type Tg737 cDNAKidney International.  50:1240-1248. 1996
    1995 Insertional mutagenesis and molecular analysis of a new gene associated with polycystic kidney disease.Proceedings of the Association of American Physicians.  107:314-323. 1995
    1994 Identification of a new spore coat protein gene in the cellular slime mold Dictyostelium discoideumDevelopmental Biology.  163:49-65. 1994
    1994 The promoter of a gene encoding a novel Dictyostelium spore coat proteinDevelopmental Biology.  163:38-48. 1994
    1991 Gene expression and chromatin structure in the cellular slime mold, Dictyostelium discoideumDevelopmental Genetics.  12:65-77. 1991

    Chapter

    Year Title Altmetric
    2017 Inflammation and fibrosis in polycystic kidney disease.  323-344. 2017
    2013 Renal Cilia Structure, Function, and Physiology.  319-346. 2013
    2013 Neuronal cilia and obesity.  165-191. 2013

    Research Overview

  • Cilia come in both motile and immotile forms. While motile cilia were known to have important roles in the lung and respiratory system, primary cilia were largely considered vestigial structures. A major paradigm shift in the field occurred with the generation of mouse mutants (such as the orpk mouse) that disrupt cilia formation. These new mouse mutants revealed important and novel roles for motile and immotile cilia and demonstrated that they are essential for mammalian development and tissue function. Defects in cilia have been implicated as the cause of a large and rapidly expanding group of human syndromes (Ciliopathies) with a wide range of developmental and disease phenotypes.

    The objectives of my research program are to uncover mechanisms regulating assembly, maintenance, and functions of both motile and primary forms of cilia and to determine how defects in these processes contribute to developmental abnormalities and disease pathogenesis. To accomplish these goals, my group utilizes complementary cell, genetic, and biochemical approaches in mice, C. elegans, and cell culture to identify new proteins involved in ciliogenesis and cilia mediated signaling. Work from my group has identified novel components of the ciliary transition zone, an important domain controlling what protein enter or are retained in the cilium. We have provided seminal insights into how the cilium regulates developmental pathways, such as hedgehog, and how alterations in cilia-mediated regulation of this pathway cause polydactyly, defects in endochondral bone formation, and abnormal skin and hair follicle morphogenesis. My group made fundamental contributions that connected ciliary dysfunction to the formation of cysts in the kidney, liver, and pancreas, and uncovered a new role for cilia on hypothalamic neurons in regulating satiation responses. We have shown that disruption of cilia on these neurons cause obesity and type II diabetes. We also identified genes important in regulating ciliary motility and waveform and determined that their loss in mice leads to hydrocephalus, bronchiectasis, and randomization of the left-right body axis. Importantly, as part of this work we determined that a mutation of one of these genes we identified in our mouse model is responsible for a form of primary ciliary dyskinesia (PCD) in humans. As in the mouse model, these human PCD patients frequently have left-right body situs defects.

    In summary, the research conducted by my group is providing important and innovative insights into how cilia are constructed and how they establish themselves as a unique signaling and sensory organelle with a distinct protein composition the rest of the cell membrane. We have uncovered many diverse and unexpected roles for cilia during development and in maintaining mammalian health.
  • Principal Investigator On

  • Training Program in Cell, Molecular, and Developmental Biology  awarded by National Institute of General Medical Sciences/NIH/DHHS 2018 - 2023
  • The Primary Cilium as A Novel Regulator of The Immune Response in The Kidney  awarded by National Institute of Diabetes and Digestive and Kidney Diseases/NIH/DHHS 2019 - 2022
  • Injury Response Mediated Pathogenesis in Renal Ciliopathies  awarded by National Institute of Diabetes and Digestive and Kidney Diseases/NIH/DHHS 2018 - 2021
  • Understanding Ciliary Functions in Mammalian Development  awarded by University of California, San Francisco 2016 - 2021
  • Acquiring A Recirculating Aquaria System With Automated-Feed For Zebrafish  awarded by UNIVERSITY OF ALABAMA HEALTH SERVICES FOUNDATION 2018 - 2020
  • Hepato/Renal Fibrocystic Diseases Core Center (UAB HRFDCC) - Admin Core  awarded by National Institute of Diabetes and Digestive and Kidney Diseases/NIH/DHHS 2015 - 2020
  • Hepato/Renal Fibrocystic Diseases Core Center (UAB HRFDCC) - Hepato/Renal Fibrocystic Kidney Disease Core Center - Summer Research Internship  awarded by National Institute of Diabetes and Digestive and Kidney Diseases/NIH/DHHS 2015 - 2020
  • Hepato/Renal Fibrocystic Diseases Core Center (UAB HRFDCC) - Pilot and Feasibility Program  awarded by National Institute of Diabetes and Digestive and Kidney Diseases/NIH/DHHS 2015 - 2020
  • Hepato/Renal Fibrocystic Diseases Core Center (UAB HRFDCC) - The Hepato/Renal Fibrocystic Diseases Cellular Physiology Resource - Core C  awarded by National Institute of Diabetes and Digestive and Kidney Diseases/NIH/DHHS 2015 - 2020
  • Hepato/Renal Fibrocystic Diseases Core Center (UAB HRFDCC) - The Hepato/Renal Fibrocystic Diseases Engineered Models Resource - Core B  awarded by National Institute of Diabetes and Digestive and Kidney Diseases/NIH/DHHS 2015 - 2020
  • Hepato/Renal Fibrocystic Diseases Core Center (UAB HRFDCC) - The Hepato/Renal Fibrocystic Diseases Translational Resource - Core A  awarded by National Institute of Diabetes and Digestive and Kidney Diseases/NIH/DHHS 2015 - 2020
  • The Hepato/Renal Fibrocystic Disease Core Center (UAB HRFDCC)  awarded by National Institute of Diabetes and Digestive and Kidney Diseases/NIH/DHHS 2015 - 2020
  • Epigenetic Regulation of Kir4.1 and GLT1 in Pathophysiology  awarded by VIRGINIA TECH UNIVERSITY 2017 - 2019
  • Cilia and Cystic Kidney Disease  awarded by National Institute of Diabetes and Digestive and Kidney Diseases/NIH/DHHS 2013 - 2019
  • Predoctoral Training in Cell and Molecular Biology  awarded by National Institute of General Medical Sciences/NIH/DHHS 2013 - 2018
  • Ciliogenesis in Epithelial Injury  awarded by MASSACHUSETTS GENERAL HOSPITAL 2014 - 2018
  • Injury Response Mediated Pathogenesis in Ciliopathies  awarded by Polycystic Kidney Disease Foundation 2016 - 2018
  • Hepato/Renal Fibrocystic Diseases Core Center (UAB HRFDCC)  awarded by National Institute of Diabetes and Digestive and Kidney Diseases/NIH/DHHS 2011 - 2016
  • Hepato/Renal Fibrocystic Diseases Core Center (UAB HRFDCC) - Administrative Core  awarded by National Institute of Diabetes and Digestive and Kidney Diseases/NIH/DHHS 2011 - 2016
  • Hepato/Renal Fibrocystic Diseases Core Center (UAB HRFDCC) - Core A  awarded by National Institute of Diabetes and Digestive and Kidney Diseases/NIH/DHHS 2011 - 2016
  • Hepato/Renal Fibrocystic Diseases Core Center (UAB HRFDCC) - Core B  awarded by National Institute of Diabetes and Digestive and Kidney Diseases/NIH/DHHS 2011 - 2016
  • Hepato/Renal Fibrocystic Diseases Core Center (UAB HRFDCC) - Core C MUSC  awarded by National Institute of Diabetes and Digestive and Kidney Diseases/NIH/DHHS 2011 - 2016
  • Hepato/Renal Fibrocystic Diseases Core Center (UAB HRFDCC) - Summer Research Internship  awarded by National Institute of Diabetes and Digestive and Kidney Diseases/NIH/DHHS 2011 - 2016
  • Private Grant  awarded by OTSUKA AMERICA PHARMACEUTICAL, INC. 2016
  • Private Grant  awarded by RELYPSA - NEW 2016
  • In Vivo Analysis of Cilia Mechanosensation in the Kidney  awarded by PKD Foundation for Research in Polycystic Kidney Disease 2014 - 2016
  • Intraflagellar Transport Mediated Regulation of Hedgehog Signaling  awarded by National Institute of Child Health and Human Development/NIH/DHHS 2008 - 2014
  • Role of Cilia/IFT in Skin and Hair  awarded by National Institute of Arthritis & Musculoskeletal & Skin Diseases/NIH/DHHS 2008 - 2014
  • Predoctoral Training in Cellular and Molecular Biology  awarded by National Institute of General Medical Sciences/NIH/DHHS 2009 - 2013
  • Private Grant  awarded by Genentech 2012 - 2013
  • Cilia and Cystic Kidney Disease  awarded by National Institute of Diabetes and Digestive and Kidney Diseases/NIH/DHHS 2008 - 2013
  • Cilial Dysfunction and Pathogenesis of Obesity  awarded by National Institute of Diabetes and Digestive and Kidney Diseases/NIH/DHHS 2006 - 2012
  • The Role of Primary Neuronal Cilia in Appetite and Satiation  awarded by National Institute of Diabetes and Digestive and Kidney Diseases/NIH/DHHS 2010 - 2012
  • Hepato/Renal Fibrocystic Diseases Core Center (UAB HRFDCC) - Core B  awarded by National Institute of Diabetes and Digestive and Kidney Diseases/NIH/DHHS 2010 - 2011
  • UAB Recessive PKD Research and Translational Core Center - Core B  awarded by National Institute of Diabetes and Digestive and Kidney Diseases/NIH/DHHS 2005 - 2010
  • Rheumatic Diseases Core Center: Pilot Project - P & F 1  awarded by National Institute of Arthritis & Musculoskeletal & Skin Diseases/NIH/DHHS 2008 - 2010
  • Investigator On

  • Interdisciplinary Training In Kidney Related Research  awarded by National Institute of Diabetes and Digestive and Kidney Diseases/NIH/DHHS 2019 - 2024
  • Mononuclear Phagocytes in the Pathogenesis of Acute Kidney Injury  awarded by National Institute of Diabetes and Digestive and Kidney Diseases/NIH/DHHS 2019 - 2023
  • The Role of Lhx1 in Pancreatic Beta Cell Development and Function  awarded by National Institute of Diabetes and Digestive and Kidney Diseases/NIH/DHHS 2017 - 2021
  • Improving Resolution and Throughput on the HRIF Institutional Core  awarded by UNIVERSITY OF ALABAMA HEALTH SERVICES FOUNDATION 2018 - 2020
  • Hepato/Renal Fibrocystic Diseases Core Center (UAB HRFDCC) - The Hepato/Renal Fibrocystic Diseases Therapeutic and Screening Resource - Core D  awarded by National Institute of Diabetes and Digestive and Kidney Diseases/NIH/DHHS 2015 - 2020
  • The Hepato/Renal Fibrocystic Disease Core Center (UAB HRFDCC)  awarded by National Institute of Diabetes and Digestive and Kidney Diseases/NIH/DHHS 2015 - 2020
  • Genetic Regulation of Unconventional Prostaglandin Metobolism  awarded by National Institute of General Medical Sciences/NIH/DHHS 2018 - 2020
  • Interdisciplinary Training in Kidney-Related Research  awarded by National Institute of Diabetes and Digestive and Kidney Diseases/NIH/DHHS 2014 - 2019
  • Mechanisms of C3 Effects in ARPKD Pathogenesis  awarded by National Institute of Diabetes and Digestive and Kidney Diseases/NIH/DHHS 2013 - 2018
  • UAB Obesity Training Program  awarded by National Institute of Diabetes and Digestive and Kidney Diseases/NIH/DHHS 2014 - 2017
  • Light-Induced Genetic Alterations Within Single Cell of a Live Vertebrate Animal  awarded by National Institute of Neurological Disorders and Stroke/NIH/DHHS 2014 - 2016
  • Hepato/Renal Fibrocystic Diseases Core Center (UAB HRFDCC)  awarded by National Institute of Diabetes and Digestive and Kidney Diseases/NIH/DHHS 2011 - 2016
  • Human Heme Oxygenase-1 Gene Regulation in Renal Injury  awarded by National Institute of Diabetes and Digestive and Kidney Diseases/NIH/DHHS 2008 - 2014
  • Rheumatic Diseases Core Center  awarded by National Institute of Arthritis & Musculoskeletal & Skin Diseases/NIH/DHHS 2008 - 2012
  • Hepato/Renal Fibrocystic Diseases Core Center (UAB HRFDCC)  awarded by National Institute of Diabetes and Digestive and Kidney Diseases/NIH/DHHS 2010 - 2011
  • UAB Recessive PKD Research and Translational Core Center  awarded by National Institute of Diabetes and Digestive and Kidney Diseases/NIH/DHHS 2005 - 2010
  • Teaching Activities

  • GBS712 - Cell & Mol Aspects Dev Bio (Spring Term 2019) 2019
  • GBSC700 - Journal Clubs (Spring Term 2019) 2019
  • GBSC733 - Art of Reproducible Science (Spring Term 2019) 2019
  • GBS712 - Cell/Mol Aspects Dev Bio (Spring Term 2017) 2017
  • GBS746 - Special Topics (Fall Term 2016) 2016
  • GBS792 - CMDB Seminar (Spring Term 2016) 2016
  • GBS792 - CMDB Seminar (Fall Term 2015) 2015
  • GBS712 - Cell/Mol Aspects Dev Bio (Spring Term 2015) 2015
  • GBS792 - CMDB Seminar (Spring Term 2015) 2015
  • GBS792 - CMDB Seminar (Fall Term 2014) 2014
  • GBS712 - Cell/Mol Aspects Dev Bio (Spring Term 2014) 2014
  • GBS787 - Special Topics (Spring Term 2014) 2014
  • GBS792 - CMDB Seminar (Spring Term 2014) 2014
  • GBS792 - CMDB Seminar (Fall Term 2013) 2013
  • GBS712 - Cell/Mol Aspects Dev Bio (Spring Term 2013) 2013
  • GBS792 - CMDB Seminar (Spring Term 2013) 2013
  • GBS792 - CMDB Seminar (Fall Term 2012) 2012
  • GBS712 - Cell/Mol Aspects Dev Bio (Spring Term 2012) 2012
  • GBS792 - CMDB Seminar (Spring Term 2012) 2012
  • GBS712 - CELL AND MOLECULAR ASPECTS OF DEVELOPMENTAL BIOLOGY (Spring Term 2012) 2012
  • GBS792 - CMDB Seminar (Fall Term 2011) 2011
  • GBS712 - Cell/Mol Aspects Dev Bio (Spring Term 2011) 2011
  • CB747 - Cell Biology Seminar (Spring Term 2010) 2010
  • CMB755 - CMB V Cell & Mole Aspt Dev BY (Spring Term 2010) 2010
  • CB747 - Cell Biology Seminar (Fall Term 2009) 2009
  • CMB755 - CMB V Cell & Mole Aspt Dev BY (Spring Term 2009) 2009
  • CB747 - Cell Biology Seminar (Fall Term 2008) 2008
  • CB747 - Cell Biology Seminar (Spring Term 2008) 2008
  • CMB755 - CMB V Cell & Mole Aspt Dev BY (Spring Term 2008) 2008
  • CB747 - Cell Biology Seminar (Fall Term 2007) 2007
  • Full Name

  • Bradley Yoder