Year |
Title |
Altmetric |
2022
|
CD206+ resident macrophages are a candidate biomarker for renal cystic disease in preclinical models and patients with ADPKD..
Disease Models and Mechanisms.
2022
|
|
2022
|
Variable phenotypes and penetrance between and within different zebrafish ciliary transition zone mutants.
Disease Models and Mechanisms.
15.
2022
|
|
2022
|
Resident macrophage subpopulations occupy distinct microenvironments in the kidney.
JCI Insight.
7.
2022
|
|
2022
|
A transgenic Alx4-CreER mouse to analyze anterior limb and nephric duct development.
Developmental Dynamics.
251:1524-1534.
2022
|
|
2022
|
A Comprehensive Immune Cell Atlas of Cystic Kidney Disease Reveals the Involvement of Adaptive Immune Cells in Injury-Mediated Cyst Progression in Mice.
Journal of the American Society of Nephrology.
33:747-768.
2022
|
|
2022
|
Evolutionarily conserved genetic interactions between nphp-4 and bbs-5 mutations exacerbate ciliopathy phenotypes
2022
|
|
2022
|
Elevated Protein Kinase A Activity in Stomach Mesenchyme Disrupts Mesenchymal-epithelial Crosstalk and Induces Preneoplasia..
Cellular and Molecular Gastroenterology and Hepatology.
14:643-668.e1.
2022
|
|
2021
|
ATXN10 Is Required for Embryonic Heart Development and Maintenance of Epithelial Cell Phenotypes in the Adult Kidney and Pancreas.
Frontiers in Cell and Developmental Biology.
9.
2021
|
|
2021
|
Early infiltrating macrophage subtype correlates with late-stage phenotypic outcome in a mouse model of hepatorenal fibrocystic disease.
Laboratory Investigation.
101:1382-1393.
2021
|
|
2021
|
Kidney resident macrophages in the rat have minimal turnover and replacement by blood monocytes
2021
|
|
2021
|
Ly6chi Infiltrating Macrophages Promote Cyst Progression in Injured Conditional Ift88 Mice.
2021
|
|
2021
|
A mouse model of BBS identifies developmental and homeostatic effects of BBS5 mutation and identifies novel pituitary abnormalities.
Human Molecular Genetics.
30:234-246.
2021
|
|
2021
|
Resident Macrophages in Cystic Kidney Disease.
2021
|
|
2021
|
A ciliopathy complex builds distal appendages to initiate ciliogenesis
2021
|
|
2020
|
Human transcription factors responsive to initial reprogramming predominantly undergo legitimate reprogramming during fibroblast conversion to iPSCs.
Scientific Reports.
10.
2020
|
|
2020
|
BBSome component BBS5 is required for cone photoreceptor protein trafficking and outer segment maintenance
2020
|
|
2020
|
Interferon Regulatory Factor-5 in Resident Macrophage Promotes Polycystic Kidney Disease.
2020
|
|
2019
|
Increased flux through the mevalonate pathway mediates fibrotic repair without injury.
Journal of Clinical Investigation.
129:4962-4978.
2019
|
|
2019
|
Single-cell RNA sequencing identifies candidate renal resident macrophage gene expression signatures across species.
Journal of the American Society of Nephrology.
30:767-781.
2019
|
|
2019
|
Heterozygous Pkhd1C642* mice develop cystic liver disease and proximal tubule ectasia that mimics radiographic signs of medullary sponge kidney
2019
|
|
2019
|
Truncating PKHD1 and PKD2 mutations alter energy metabolism
2019
|
|
2019
|
Resident macrophages reprogram toward a developmental state after acute kidney injury.
JCI Insight.
4.
2019
|
|
2019
|
Mks6 mutations reveal tissue-and cell type-specific roles for the cilia transition zone
2019
|
|
2019
|
Tissue-resident macrophages promote renal cystic disease.
Journal of the American Society of Nephrology.
30:1841-1856.
2019
|
|
2019
|
Urinary T cells correlate with rate of renal function loss in autosomal dominant polycystic kidney disease.
Physiological Reports.
7.
2019
|
|
2018
|
Role for intraflagellar transport in building a functional transition zone.
EMBO Reports.
19.
2018
|
|
2018
|
Primary cilia disruption differentially affects the infiltrating and resident macrophage compartment in the liver
2018
|
|
2018
|
Ectopic Phosphorylated Creb Marks Dedifferentiated Proximal Tubules in Cystic Kidney Disease.
American Journal of Pathology.
188:84-94.
2018
|
|
2016
|
Mutation of Growth Arrest Specific 8 Reveals a Role in Motile Cilia Function and Human Disease.
PLoS Genetics.
12.
2016
|
|
2016
|
The tumor-associated glycosyltransferase ST6Gal-I regulates stem cell transcription factors and confers a cancer stem cell phenotype.
Cancer Research.
76:3978-3988.
2016
|
|
2016
|
Coiled-coil domain containing 42 (Ccdc42) is necessary for proper sperm development and male fertility in the mouse.
Developmental Biology.
412:208-218.
2016
|
|
2016
|
A Screen for Modifiers of Cilia Phenotypes Reveals Novel MKS Alleles and Uncovers a Specific Genetic Interaction between osm-3 and nphp-4.
PLoS Genetics.
12.
2016
|
|
2016
|
Non-essential role for cilia in coordinating precise alignment of lens fibres.
Mechanisms of Development.
139:10-17.
2016
|
|
2015
|
KIAA0556 is a novel ciliary basal body component mutated in Joubert syndrome.
Genome Biology.
16.
2015
|
|
2015
|
Genetic and informatic analyses implicate Kif12 as a candidate gene within the Mpkd2 locus that modulates renal cystic disease severity in the Cys1cpk mouse.
PLoS One.
10.
2015
|
|
2015
|
Heterotrimeric Kinesin-2 (KIF3) mediates transition zone and axoneme formation of mouse photoreceptors.
Journal of Biological Chemistry.
290:12765-12778.
2015
|
|
2015
|
Snap Shot: Sensing and signaling by cilia.
Cell.
161:692-692.e1.
2015
|
|
2014
|
High-throughput genome editing and phenotyping facilitated by high resolution melting curve analysis.
PLoS One.
9.
2014
|
|
2014
|
Complement C3 activation in cyst fluid and urine from autosomal dominant polycystic kidney disease patients.
Journal of Internal Medicine.
276:539-540.
2014
|
|
2014
|
Hippocampal and cortical primary cilia are required for aversive memory in mice.
PLoS One.
9.
2014
|
|
2014
|
Primary cilia enhance kisspeptin receptor signaling on gonadotropin- releasing hormone neurons
2014
|
|
2014
|
Aberrant expression of laminin-332 promotes cell proliferation and cyst growth in ARPKD
2014
|
|
2014
|
Deletion of airway cilia results in noninflammatory bronchiectasis and hyperreactive airways
2014
|
|
2014
|
Monitoring endosomal trafficking of the g protein-coupled receptor somatostatin receptor 3.
Methods in Enzymology.
534:261-280.
2014
|
|
2013
|
An inducible CiliaGFP mouse model for in vivo visualization and analysis of cilia in live tissue.
Cilia.
2.
2013
|
|
2013
|
Leptin resistance is a secondary consequence of the obesity in ciliopathy mutant mice
2013
|
|
2013
|
Quantitative Peptidomics of Purkinje Cell Degeneration Mice.
PLoS One.
8.
2013
|
|
2013
|
Proximal tubule proliferation is insufficient to induce rapid cyst formation after cilia disruption.
Journal of the American Society of Nephrology.
24:456-464.
2013
|
|
2013
|
Microtubule modifications and stability are altered by cilia perturbation and in cystic kidney disease.
Cytoskeleton.
70:24-31.
2013
|
|
2012
|
Mammalian Clusterin associated protein 1 is an evolutionarily conserved protein required for ciliogenesis.
Cilia.
1.
2012
|
|
2012
|
Gene therapy rescues cilia defects and restores olfactory function in a mammalian ciliopathy model.
Nature Medicine.
18:1423-1428.
2012
|
|
2012
|
Kidney injury accelerates cystogenesis via pathways modulated by heme oxygenase and complement.
Journal of the American Society of Nephrology.
23:1161-1171.
2012
|
|
2012
|
Increased Na+/H+ exchanger activity on the apical surface of a cilium-deficient cortical collecting duct principal cell model of polycystic kidney disease
2012
|
|
2011
|
Assessing the pathogenic potential of human nephronophthisis disease-associated NPHP-4 missense mutations in C. elegans.
Human Molecular Genetics.
20:2942-2954.
2011
|
|
2011
|
Loss of primary cilia upregulates renal hypertrophic signaling and promotes cystogenesis.
Journal of the American Society of Nephrology.
22:839-848.
2011
|
|
2011
|
Role of epidermal primary cilia in the homeostasis of skin and hair follicles
2011
|
|
2011
|
Lack of primary cilia primes shear-induced endothelial-to-mesenchymal transition.
Circulation Research.
108:1093-1101.
2011
|
|
2011
|
MKS and NPHP modules cooperate to establish basal body/transition zone membrane associations and ciliary gate function during ciliogenesis
2011
|
|
2011
|
Soluble levels of cytosolic tubulin regulate ciliary length control.
Molecular Biology of the Cell.
22:806-816.
2011
|
|
2011
|
GMAP210 and IFT88 are present in the spermatid golgi apparatus and participate in the development of the acrosome-acroplaxome complex, head-tail coupling apparatus and tail.
Developmental Dynamics.
240:723-736.
2011
|
|
2011
|
Erratum: In vivo fate mapping and expression analysis reveals molecular hallmarks of prospectively isolated adult neural stem cells (Cell Stem Cell (2010) 7 (744-758)).
Cell Stem Cell.
8:119.
2011
|
|
2011
|
Mutations in Traf3ip1 reveal defects in ciliogenesis, embryonic development, and altered cell size regulation.
Developmental Biology.
360:66-76.
2011
|
|
2010
|
In vivo fate mapping and expression analysis reveals molecular hallmarks of prospectively isolated adult neural stem cells.
Cell Stem Cell.
7:744-758.
2010
|
|
2010
|
The zebrafish foxj1a transcription factor regulates cilia function in response to injury and epithelial stretch
2010
|
|
2010
|
Directional cell migration and chemotaxis in wound healing response to PDGF-AA are coordinated by the primary cilium in fibroblasts.
Cellular Physiology and Biochemistry.
25:279-292.
2010
|
|
2010
|
Normal ciliogenesis requires synergy between the cystic kidney disease genes MKS-3 and NPHP-4.
Journal of the American Society of Nephrology.
21:782-793.
2010
|
|
2009
|
The primary cilium coordinates early cardiogenesis and hedgehog signaling in cardiomyocyte differentiation.
Journal of Cell Science.
122:3070-3082.
2009
|
|
2009
|
The Primary Cilium as a Complex Signaling Center.
Current Biology.
19.
2009
|
|
2009
|
Primary cilia regulate Shh activity in the control of molar tooth number
2009
|
|
2009
|
Primary cilia and signaling pathways in mammalian development, health and disease
2009
|
|
2009
|
An essential role for dermal primary cilia in hair follicle morphogenesis.
Journal of Investigative Dermatology.
129:438-448.
2009
|
|
2009
|
Generating conditional mutants to analyze ciliary functions: the use of Cre-lox technology to disrupt cilia in specific organs..
Methods in Cell Biology.
93:305-330.
2009
|
|
2009
|
Utilization of conditional alleles to study the role of the primary cilium in obesity..
Methods in Cell Biology.
94:162-179.
2009
|
|
2008
|
Chapter 13 Ciliary Dysfunction in Developmental Abnormalities and Diseases.
Current Topics in Developmental Biology.
85:371-427.
2008
|
|
2008
|
Preface.
Current Topics in Developmental Biology.
85.
2008
|
|
2008
|
Characterization of primary cilia and hedgehog signaling during development of the human pancreas and in human pancreatic duct cancer cell lines.
Developmental Dynamics.
237:2039-2052.
2008
|
|
2008
|
Role for primary cilia in the regulation of mouse ovarian function.
Developmental Dynamics.
237:2053-2060.
2008
|
|
2008
|
The Oak Ridge Polycystic Kidney mouse: Modeling ciliopathies of mice and men.
Developmental Dynamics.
237:1960-1971.
2008
|
|
2008
|
Loss of apical monocilia on collecting duct principal cells impairs ATP secretion across the apical cell surface and ATP-dependent and flow-induced calcium signals.
Purinergic Signalling.
4:155-170.
2008
|
|
2008
|
Functional redundancy of the B9 proteins and nephrocystins in Caenorhabditis elegans ciliogenesis.
Molecular Biology of the Cell.
19:2154-2168.
2008
|
|
2008
|
THM1 negatively modulates mouse sonic hedgehog signal transduction and affects retrograde intraflagellar transport in cilia.
Nature Genetics.
40:403-410.
2008
|
|
2008
|
Ciliary proteins link basal body polarization to planar cell polarity regulation.
Nature Genetics.
40:69-77.
2008
|
|
2007
|
Disruption of Intraflagellar Transport in Adult Mice Leads to Obesity and Slow-Onset Cystic Kidney Disease.
Current Biology.
17:1586-1594.
2007
|
|
2007
|
Cilia proteins control cerebellar morphogenesis by promoting expansion of the granule progenitor pool
2007
|
|
2007
|
Articular cartilage and growth plate defects are associated with chondrocyte cytoskeletal abnormalities in Tg737orpk mice lacking the primary cilia protein polaris.
Matrix Biology.
26:234-246.
2007
|
|
2007
|
Development of the post-natal growth plate requires intraflagellar transport proteins.
Developmental Biology.
305:202-216.
2007
|
|
2007
|
Role of primary cilia in the pathogenesis of polycystic kidney disease.
Journal of the American Society of Nephrology.
18:1381-1388.
2007
|
|
2007
|
Sensory ciliogenesis in Caenorhabditis elegans: Assignment of IFT components into distinct modules based on transport and phenotypic profiles.
Molecular Biology of the Cell.
18:1554-1569.
2007
|
|
2007
|
Altered pHi regulation and Na+/HCO-3 transporter activity in choroid plexus of cilia-defective Tg737orpk mutant mouse
2007
|
|
2007
|
Intraflagellar transport is essential for endochondral bone formation
2007
|
|
2006
|
Caenorhabditis elegans DYF-2, an orthologue of human WDR19, is a component of the intraflagellar transport machinery in sensory cilia.
Molecular Biology of the Cell.
17:4801-4811.
2006
|
|
2006
|
IFTA-2 is a conserved cilia protein involved in pathways regulating longevity dauer formation in Caenorhabditis elegans.
Journal of Cell Science.
119:4088-4100.
2006
|
|
2006
|
The primary cilium in cell signaling and cancer.
Cancer Research.
66:6463-6467.
2006
|
|
2006
|
More Than Just the Postal Service: Novel Roles for IFT Proteins in Signal Transduction.
Developmental Cell.
10:541-542.
2006
|
|
2006
|
Heightened epithelial Na+ channel-mediated Na+ absorption in a murine polycystic kidney disease model epithelium lacking apical monocilia
2006
|
|
2006
|
Loss of primary cilia results in deregulated and unabated apical calcium entry in ARPKD collecting duct cells
2006
|
|
2006
|
Molecular pathogenesis of autosomal dominant polycystic kidney disease.
Expert Reviews in Molecular Medicine.
8:1-22.
2006
|
|
2005
|
Dysfunctional cilia lead to altered ependyma and choroid plexus function, and result in the formation of hydrocephalus
2005
|
|
2005
|
The C. elegans homologs of nephrocystin-1 and nephrocystin-4 are cilia transition zone proteins involved in chemosensory perception.
Journal of Cell Science.
118:5575-5587.
2005
|
|
2005
|
Gli2 and Gli3 localize to cilia and require the intraflagellar transport protein polaris for processing and function..
PLoS Genetics.
1.
2005
|
|
2005
|
Cilia-driven fluid flow in the zebrafish pronephros, brain and Kupffer's vesicle is required for normal organogenesis
2005
|
|
2005
|
An incredible decade for the primary cilium: A look at a once-forgotten organelle
2005
|
|
2005
|
Disruption of IFT results in both exocrine and endocrine abnormalities in the pancreas of Tg737orpk mutant mice.
Laboratory Investigation.
85:45-64.
2005
|
|
2005
|
Gli2 and Gli3 localize to cilia and require the intraflagellar transport protein polaris for processing and function.
PLoS Genetics.
1:0480-0488.
2005
|
|
2005
|
Mechanoregulation of intracellular Ca2+ concentration is attenuated in collecting duct of monocilium-impaired orpk mice
2005
|
|
2004
|
Comparative genomics identifies a flagellar and basal body proteome that includes the BBS5 human disease gene.
Cell.
117:541-552.
2004
|
|
2004
|
Cystic kidney diseases: All roads lead to the cilium.
Physiology.
19:225-230.
2004
|
|
2003
|
A novel dynein light intermediate chain colocalizes with the retrograde motor for intraflagellar transport at sites of axoneme assembly in Chlamydomonas and mammalian cells.
Molecular Biology of the Cell.
14:2041-2056.
2003
|
|
2003
|
Loss of the Tg737 protein results in skeletal patterning defects.
Developmental Dynamics.
227:78-90.
2003
|
|
2003
|
XBX-1 encodes a dynein light intermediate chain required for retrograde intraflagellar transport and cilia assembly in Caenorhabditis elegans.
Molecular Biology of the Cell.
14:2057-2070.
2003
|
|
2003
|
Identification of CHE-13, a novel intraflagellar transport protein required for cilia formation.
Experimental Cell Research.
284:249-261.
2003
|
|
2002
|
Comparative gene expression profile analysis of GLI and c-MYC in an epithelial model of malignant transformation.
Cancer Research.
62:5867-5873.
2002
|
|
2002
|
The polycystic kidney disease proteins, polycystin-1, polycystin-2, polaris, and cystin, are co-localized in renal cilia.
Journal of the American Society of Nephrology.
13:2508-2516.
2002
|
|
2002
|
Polaris, a protein disrupted in orpk mutant mice, is required for assembly of renal cilium.
2002
|
|
2002
|
Cystin, a novel cilia-associated protein, is disrupted in the cpk mouse model of polycystic kidney disease..
Journal of Clinical Investigation.
109:533-540.
2002
|
|
2002
|
Cystin, a novel cilia-associated protein, is disrupted in the cpk mouse model of polycystic kidney disease.
Journal of Clinical Investigation.
109:533-540.
2002
|
|
2002
|
Polaris, a protein disrupted in orpk mutant mice, is required for assembly of renal cilium
2002
|
|
2001
|
The C. elegans homolog of the murine cystic kidney disease gene Tg737 functions in a ciliogenic pathway and is disrupted in osm-5 mutant worms
2001
|
|
2001
|
Jets: A modification to speed flexible oligonucleotide array construction
2001
|
|
2001
|
Polaris, a protein involved in left-right axis patterning, localizes to basal bodies and cilia.
Molecular Biology of the Cell.
12:589-599.
2001
|
|
2000
|
The Oak Ridge Polycystic Kidney (orpk) disease gene is required for left-right axis determination
2000
|
|
1998
|
Epidermal growth factor receptor activity mediates renal cyst formation in polycystic kidney disease.
Journal of Clinical Investigation.
101:935-939.
1998
|
|
1998
|
Characterization of growth factor responsiveness and alterations in growth factor homeostasis involved in the tumorigenic conversion of mouse oval cells.
Growth Factors.
15:81-94.
1998
|
|
1997
|
The combination of epidermal growth factor and transforming growth factor-β induces novel phenotypic changes in mouse liver stem cell lines.
Journal of Cell Science.
110:3117-3129.
1997
|
|
1997
|
Differential rescue of the renal and hepatic disease in an autosomal recessive polycystic kidney disease mouse mutant: A new model to study the liver lesion.
American Journal of Pathology.
150:2231-2241.
1997
|
|
1997
|
Isolation and characterization of liver epithelial cell lines from wild- type and mutant TgN737Rpw mice.
American Journal of Pathology.
150:1189-1197.
1997
|
|
1997
|
The tetratricopeptide repeat containing Tg737 gene is a liver neoplasia tumor suppressor gene.
Oncogene.
15:1797-1803.
1997
|
|
1996
|
Oval cell proliferation associated with the murine insertional mutation TgN737Rpw.
American Journal of Pathology.
149:1919-1930.
1996
|
|
1996
|
Functional correction of renal defects in a mouse model for ARPKD through expression of the cloned wild-type Tg737 cDNA.
Kidney International.
50:1240-1248.
1996
|
|
1995
|
Insertional mutagenesis and molecular analysis of a new gene associated with polycystic kidney disease..
Proceedings of the Association of American Physicians.
107:314-323.
1995
|
|
1994
|
Identification of a new spore coat protein gene in the cellular slime mold Dictyostelium discoideum.
Developmental Biology.
163:49-65.
1994
|
|
1994
|
The promoter of a gene encoding a novel Dictyostelium spore coat protein.
Developmental Biology.
163:38-48.
1994
|
|
1991
|
Gene expression and chromatin structure in the cellular slime mold, Dictyostelium discoideum
1991
|
|