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Brian Sims
Associate Professor
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bsimsmd@uab.edu
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Brian Sims
Associate Professor
Positions
Associate Professor (P)
,
Pediatric - Neonatology
,
Pediatrics
2006 -
Senior Scientist (C)
,
Center for Glial Biology in Medicine
,
Academic Joint Departments
2006 -
Associate Scientist (C)
,
Civitan International Research Center
,
Academic Joint Departments
2008 -
Associate Professor (S)
,
Cell, Developmental and Integrative Biology (CDIB)
,
Academic Joint Departments
2012 -
Associate Scientist (C)
,
Minority Health & Research Center
,
General Clinical Research Center
2014 -
Associate Professor (S)
,
Neurobiology
,
Academic Joint Departments
2015 -
Scientist (C)
,
Center for AIDS Research
,
School of Medicine
2016 -
Associate Professor (S)
,
Dept of Medical Education
,
School of Medicine
2018 -
Associate Scientist (C)
,
Center for Women's Reproductive Health
,
General Clinical Research Center
2019 -
Publications
Research
Background
Contact
Publications
Selected Publications
Academic Article
Filter
Year
Title
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2021
Effects of Cocaine on Human Glial-Derived Extracellular Vesicles
.
Frontiers in Cell and Developmental Biology
. 8.
2021
2021
Cocaine‐Specific Effects on Exosome Biogenesis in Microglial Cells
.
Neurochemical Research
.
2021
2021
Lipopolysaccharide Administration Alters Extracellular Vesicles in Cell Lines and Mice
2021
2019
Alcohol exposure impacts the composition of HeLa-derived extracellular vesicles
.
Biomedicines
. 7.
2019
2019
Effects of Pseudomonas aeruginosa on microglial-derived extracellular vesicle biogenesis and composition
.
Pathogens
. 8.
2019
2019
The role of lipopolysaccharide-induced extracellular vesicles in cardiac cell death
.
Biology
. 8.
2019
2019
The Association of Intraventricular Hemorrhage and Acute Kidney Injury in Premature Infants from the Assessment of the Worldwide Acute Kidney Injury Epidemiology in Neonates (AWAKEN) Study
2019
2019
Alcohol modulates the biogenesis and composition of microglia-derived exosomes
.
Biology
. 8.
2019
2019
Opioid Detoxification in Pregnancy: Systematic Review and Meta-Analysis of Perinatal Outcomes
2019
2018
Editor’s Choice
.
Innate Immunity
. 24:277.
2018
2018
Human breast milk-derived exosomes attenuate cell death in intestinal epithelial cells
.
Innate Immunity
. 24:278-284.
2018
2018
Tetraspanin blockage reduces exosome-mediated HIV-1 entry
.
Archives of Virology
. 163:1683-1689.
2018
2018
Exosome Biogenesis and Biological Function in Response to Viral Infections.
.
Open Virology Journal
. 12:134-148.
2018
2017
Differential binding of the HIV-1 envelope to phosphatidylserine receptors
2017
2017
Role of TIM-4 in exosome-dependent entry of HIV-1 into human immune cells
.
International Journal of Nanomedicine
. 12:4823-4833.
2017
2017
Erythropoietin-induced cytoprotection in intestinal epithelial cells is linked to system Xc
-
.
Experimental Cell Research
. 352:202-206.
2017
2016
Neonatal acute kidney injury and the risk of intraventricular hemorrhage in the very low birth weight infant
2016
2014
Neural stem cell-derived exosomes mediate viral entry
.
International Journal of Nanomedicine
. 9:4893-4897.
2014
2014
B-type natriuretic peptide and mortality in extremely low birth weight infants with pulmonary hypertension: A retrospective cohort analysis
.
BMC Pediatrics
. 14.
2014
2013
Histological characteristics of the fetal inflammatory response associated with neurodevelopmental impairment and death in extremely preterm infants
.
Journal of Pediatrics
. 163.
2013
2012
Hypoxic preconditioning involves system Xc
-
regulation in mouse neural stem cells
.
Stem Cell Research
. 8:285-291.
2012
2012
Melatonin Induces Neuroprotection via System Xc Regulation in Neural Stem Cells
.
Journal of stem cell research & therapy
. 02.
2012
2012
Vitamin D3-induced Neuroprotection is Dependent on System Xc Activity
.
Journal of stem cell research & therapy
. 02.
2012
2011
Cystine glutamate exchanger upregulation by retinoic acid induces neuroprotection in neural stem cells
.
NeuroReport
. 22:598-602.
2011
2010
Erratum: Erythropoietin-induced neuroprotection requires cystine glutamate exchanger activity (Brain Research (2010) 1321 (88-95))
.
Brain Research
. 1362:160.
2010
2010
Erythropoietin-induced neuroprotection requires cystine glutamate exchanger activity
.
Brain Research
. 1321:88-95.
2010
2009
Developmental changes in circulating IL-8/CXCL8 isoforms in neonates
.
Cytokine
. 46:12-16.
2009
1999
Regulation of AMP deaminase by phosphoinositides
.
Journal of Biological Chemistry
. 274:25701-25707.
1999
1998
Elevated adenosine monophosphate deaminase activity in Alzheimer's disease brain
.
Neurobiology of Aging
. 19:385-391.
1998
B-type natriuretic peptide is a biomarker for pulmonary hypertension in preterm infants with bronchopulmonary dysplasia
.
Research and Reports in Neonatology
. 33-33.
Chapter
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Year
Title
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2018
Biological Function of Exosomes as Diagnostic Markers and Therapeutic Delivery Vehicles in Carcinogenesis and Infectious Diseases
2018
Research
Principal Investigator On
Preparation for Graduate and Medical Education (PARAdiGM) Program
awarded by
National Heart, Lung, and Blood Institute/NIH/DHHS
2019 - 2024
Translational Research in Neuro-AIDS and Mental Health
awarded by
JOHNS HOPKINS SCHOOL OF MEDICINE
2019 - 2021
The Impact of Cocaine on Exosome Mediated HIV Entry in the CNS
awarded by
ALABAMA STATE UNIVERSITY
2018 - 2021
Investigator On
UAB Neuroscience Roadmap Scholars Program
awarded by
National Institute of Neurological Disorders and Stroke/NIH/DHHS
2020 - 2025
DNA Sequencing for Newborn Nurseries in the South
awarded by
HUDSONALPHA INSTITUTE FOR BIOTECHNOLOGY
2017 - 2021
NICHD Neonatal Research Network (NRN)
awarded by
RTI INTERNATIONAL
2017 - 2020
Comprehensive Center for Addiction in Pregnancy
awarded by
UNIVERSITY OF ALABAMA HEALTH SERVICES FOUNDATION
2017 - 2019
Private Grant
awarded by
WINDTREE THERAPEUTICS, INC.
2016 - 2019
A Phase II Multi-site Study of Autologous Cord Blood Cells for Hypoxic lschemic Encephalopathy (HIE)
awarded by
Duke University
2016 - 2018
Training Program in the Neurobiology of Cognition and Cognitive Disorders
awarded by
National Institute of Neurological Disorders and Stroke/NIH/DHHS
2013 - 2016
Private Grant
awarded by
DISCOVERY LABORATORIES, INC.
2014 - 2016
Background
Education And Training
Doctor of Medicine in Neonatal-Perinatal Medicine Residency Program,
University of Alabama at Birmingham
2000
Doctor of Philosophy in Child / Pediatric Neurology,
University of Alabama at Birmingham
1999
Bachelor of Science or Mathematics in Pediatrics Residency Program,
University of Alabama at Birmingham
1991
St. Louis Children's Hospital, Internship
2001
St. Louis Children's Hospital, Residency
2003
UAB Hospital, Postdoctoral Fellowship
2006
Contact
Full Name
Brian
Sims