Positions

Selected Publications

Academic Article

Year Title Altmetric
2017 The Natural History of Severe Acute Liver Injury.American Journal of Gastroenterology.  112:1389-1396. 2017
2017 Orthotopic liver transplantation changes the course of gastric antral vascular ectasia: a case series from a transplant center.European Journal of Gastroenterology and Hepatology.  29:973-976. 2017
2017 Current guidelines for chemoembolization for hepatocellular carcinoma: Room for improvement?Hepatology Communications.  1:338-346. 2017
2017 Association of Variants of Arginine Vasopressin and Arginine Vasopressin Receptor 1A With Severe Acetaminophen Liver InjuryCellular and Molecular Gastroenterology and Hepatology.  3:500-505. 2017
2017 Primary biliary cirrhosis has high wait-list mortality among patients listed for liver transplantation.Transplant International.  30:454-462. 2017
2017 Heat stroke leading to acute liver injury & failure: A case series from the Acute Liver Failure Study Group.Liver International.  37:509-513. 2017
2017 Sorafenib use for recurrent hepatocellular cancer after resection or transplantation: Observations from a US regional analysis of the GIDEON registry.American Journal of Surgery.  213:688-695. 2017
2017 A SEER Database Analysis of the Survival Advantage of Transarterial Chemoembolization for Hepatocellular Carcinoma: An Underutilized Therapy.JVIR: Journal of Vascular and Interventional Radiology.  28:231-237.e2. 2017
2017 Unusually High Rates of Hepatocellular Carcinoma After Treatment With Direct-Acting Antiviral Therapy for Hepatitis C Related Cirrhosis.Gastroenterology.  152:911-912. 2017
2017 HBV-Associated Acute Liver Failure After Immunosuppression and Risk of Death.Clinical Gastroenterology and Hepatology.  15:113-122. 2017
2016 Acute liver injury and acute liver failure from mushroom poisoning in North America.Liver International.  36:1043-1050. 2016
2016 Outcomes in Adults With Acute Liver Failure Between 1998 and 2013: An Observational Cohort Study.Annals of Internal Medicine.  164:724-732. 2016
2016 Terlipressin Plus Albumin Is More Effective Than Albumin Alone in Improving Renal Function in Patients With Cirrhosis and Hepatorenal Syndrome Type 1.Gastroenterology.  150:1579-1589.e2. 2016
2016 Association Between Plasma Level of Galectin-9 and Survival of Patients With Drug-Induced Acute Liver Failure.Clinical Gastroenterology and Hepatology.  14:606-612.e3. 2016
2015 Liver transplantation for alcoholic hepatitis: A survey of liver transplant centers.Liver Transplantation and Surgery.  21:1449-1452. 2015
2015 Diagnosis and Management of Hepatic Encephalopathy in Fulminant Hepatic Failure.Clinics in Liver Disease.  19:565-576. 2015
2015 Plasma osteopontin in acute liver failure.Cytokine.  73:270-276. 2015
2015 Screening and detection of hepatocellular carcinoma.Clinics in Liver Disease.  19:295-307. 2015
2015 Impact of all oral anti-hepatitis C virus therapy: A meta-analysis.World Journal of Hepatology.  7:806-813. 2015
2015 Detection of Ophthalmic Acid in Serum from Acetaminophen-Induced Acute Liver Failure Patients Is More Frequent in Non-Survivors.PLoS ONE.  10:e0139299. 2015
2015 Procalcitonin Identifies Cell Injury, Not Bacterial Infection, in Acute Liver Failure.PLoS ONE.  10:e0138566. 2015
2014 A pilot study examining the safety and tolerability of valacyclovir in veterans with hepatitis C virus/herpes simplex virus type 2 coinfection.American Journal of the Medical Sciences.  348:455-459. 2014
2014 Gastric antral vascular ectasia: a rare manifestation for gastrointestinal bleeding in left ventricular assist device patients--an initial report.Digestive Diseases and Sciences.  59:2826-2830. 2014
2014 Liver transplantation in the management of porphyria.Hepatology.  60:1082-1089. 2014
2014 Micro-RNA-122 levels in acute liver failure and chronic hepatitis C.Journal of Medical Virology.  86:1507-1514. 2014
2014 Surveillance for hepatocellular carcinoma: evidence, guidelines and utilization.American Journal of the Medical Sciences.  347:415-419. 2014
2014 Detection of anti-isoniazid and anti-cytochrome P450 antibodies in patients with isoniazid-induced liver failure.Hepatology.  59:1084-1093. 2014
2014 Steroid use in acute liver failure.Hepatology.  59:612-621. 2014
2014 Safety and yield of diagnostic ERCP in liver transplant patients with abnormal liver function tests.Diagnostic and Therapeutic Endoscopy.  2014:314927. 2014
2013 Quality of life is significantly impaired in long-term survivors of acute liver failure and particularly in acetaminophen-overdose patients.Liver Transplantation and Surgery.  19:991-1000. 2013
2013 Percutaneous balloon dilation and placement of endoscopic biliary stent by using the double-balloon enteroscopy ERCP rendezvous technique.Gastrointestinal Endoscopy.  78:383-385. 2013
2013 Double-balloon enteroscopy-ERCP rendezvous technique.Endoscopy.  45 Suppl 2:E333-E334. 2013
2012 Equivalent survival following liver transplantation in patients with non-alcoholic steatohepatitis compared with patients with other liver diseases.HPB.  14:625-634. 2012
2012 Telaprevir and boceprevir in African Americans with genotype 1 chronic hepatitis C: implications for patients and providers.Southern Medical Journal.  105:431-436. 2012
2011 A biopsychosocial approach to liver transplant evaluation in two patients with Wilson's disease.Psychology, Health and Medicine.  16:268-275. 2011
2011 Comparing the aspartate aminotransferase (AST) to platelet ratio index (APRI) between African American and White veterans with chronic hepatitis C.Southern Medical Journal.  104:309-314. 2011
2010 Pharmacology and safety of glycerol phenylbutyrate in healthy adults and adults with cirrhosis.Hepatology.  51:2077-2085. 2010
2010 Autoimmune hepatitis-primary sclerosing cholangitis overlap syndrome complicated by Crohn's disease.Digestion.  82:24-26. 2010
2009 Current trends in the treatment of hepatic encephalopathyTherapeutics and Clinical Risk Management.  5:617-626. 2009
2009 Outcome of acute liver failure in the elderly.Liver Transplantation and Surgery.  15:1481-1487. 2009
2009 Long-term management of the liver transplant patient: recommendations for the primary care doctor.American Journal of Transplantation.  9:1988-2003. 2009
2009 Pharmacokinetics of tacrolimus co-administered with adefovir dipivoxil to liver transplant recipients.Liver International.  29:1178-1183. 2009
2009 Current trends in the treatment of hepatic encephalopathy.Therapeutics and Clinical Risk Management.  5:617-626. 2009
2009 Editorial comment: liver transplantation.Current Opinion in Organ Transplantation.  14:219-220. 2009
2009 Editorial introductionsCurrent Opinion in Organ Transplantation.  14. 2009
2009 Performance of the hepatic encephalopathy scoring algorithm in a clinical trial of patients with cirrhosis and severe hepatic encephalopathy.American Journal of Gastroenterology.  104:1392-1400. 2009
2009 HFE hemochromatosis and hepatic sarcoid.American Journal of the Medical Sciences.  337:386-390. 2009
2009 The role of etiology in the hyperamylasemia of acute liver failure.American Journal of Gastroenterology.  104:592-597. 2009
2009 Hepatic assist devices: will they ever be successful?Current Gastroenterology Reports.  11:64-68. 2009
2008 Detection and diagnosis of herpes simplex virus infection in adults with acute liver failure.Liver Transplantation and Surgery.  14:1498-1504. 2008
2008 Screening for Wilson disease in acute liver failure: a comparison of currently available diagnostic tests.Hepatology.  48:1167-1174. 2008
2008 The coagulopathy of acute liver failure and implications for intracranial pressure monitoring.Neurocritical Care.  9:103-107. 2008
2007 Electrophoretic methods for analysis of urinary polypeptides in IgA-associated renal diseases.ELECTROPHORESIS.  28:4469-4483. 2007
2007 Randomized controlled study of extracorporeal albumin dialysis for hepatic encephalopathy in advanced cirrhosis.Hepatology.  46:1853-1862. 2007
2007 Antimitochondrial antibodies in acute liver failure: implications for primary biliary cirrhosis.Hepatology.  46:1436-1442. 2007
2007 Intensive care of patients with acute liver failure: recommendations of the U.S. Acute Liver Failure Study Group.Critical Care Medicine.  35:2498-2508. 2007
2007 Intermittent unexplained abdominal pain: is it porphyria?Clinical Gastroenterology and Hepatology.  5:1255-1258. 2007
2007 Urinary biomarkers of IgA nephropathy and other IgA-associated renal diseases.World Journal of Urology.  25:467-476. 2007
2007 Predictive value of actin-free Gc-globulin in acute liver failure.Liver Transplantation and Surgery.  13:1324-1329. 2007
2007 Retransplantation for hepatitis C: results of a U.S. multicenter retransplant study.Liver Transplantation and Surgery.  13:1246-1253. 2007
2007 Elevated troponin I levels in acute liver failure: is myocardial injury an integral part of acute liver failure?Hepatology.  45:1489-1495. 2007
2007 Use of extracorporeal albumin dialysis for erythropoietic protoporphyria.Liver Transplantation and Surgery.  13:639-640. 2007
2006 Alpha-fetoprotein and prognosis in acute liver failure.Liver Transplantation and Surgery.  12:1776-1781. 2006
2006 Fulminant hepatitis A virus infection in the United States: Incidence, prognosis, and outcomes.Hepatology.  44:1589-1597. 2006
2006 Detection of acetaminophen protein adducts in children with acute liver failure of indeterminate cause.Pediatrics.  118:e676-e681. 2006
2006 Outpatient management of cirrhosis: a narrative review.Southern Medical Journal.  99:600-606. 2006
2006 Brief communication: Glomerulonephritis in patients with hepatitis C cirrhosis undergoing liver transplantation.Annals of Internal Medicine.  144:735-741. 2006
2006 Acute liver failure in children: the first 348 patients in the pediatric acute liver failure study group.Journal of Pediatrics.  148:652-658. 2006
2006 Hepatic encephalopathy: a review of its pathophysiology and treatment.Current Treatment Options in Gastroenterology.  9:464-474. 2006
2005 Liver transplantation for erythropoietic protoporphyria liver disease.Liver Transplantation and Surgery.  11:1590-1596. 2005
2005 Gc-globulin and prognosis in acute liver failure.Liver Transplantation and Surgery.  11:1223-1227. 2005
2004 Two-dose daclizumab induction therapy in 209 liver transplants: a single-center analysis.Transplantation.  78:1212-1217. 2004
2004 Prospective, randomized, multicenter, controlled trial of a bioartificial liver in treating acute liver failure.Annals of Surgery.  239:660-667. 2004
2003 Influence of hepatic encephalopathy on health-related quality of life in patients with cirrhosis.Digestive Diseases and Sciences.  48:1622-1626. 2003
2003 Viral hepatitis-related acute liver failure.American Journal of Gastroenterology.  98:448-453. 2003
2003 The critically ill liver patient: fulminant hepatic failure.Seminars in Gastrointestinal Disease.  14:39-42. 2003
2002 Results of a prospective study of acute liver failure at 17 tertiary care centers in the United States.Annals of Internal Medicine.  137:947-954. 2002
2002 A pilot study of interferon alfa and ribavirin combination in liver transplant recipients with recurrent hepatitis C.Hepatology.  36:1253-1258. 2002
2002 Impact of noncompliance and donor/recipient race matching on chronic liver rejection.Transplantation Proceedings.  34:1497-1498. 2002
2002 Use of preserved vascular homografts in liver transplantation: hepatic artery aneurysms and other complications.American Journal of Transplantation.  2:471-475. 2002
2002 Implementation of vaccination in patients with cirrhosis.Digestive Diseases and Sciences.  47:384-387. 2002
2001 The use of screening and preventive therapies for gastroesophageal varices in patients referred for evaluation of orthotopic liver transplantationAmerican Journal of Gastroenterology.  96:833-837. 2001
2001 The use of screening and preventive therapies for gastroesophageal varices in patients referred for evaluation of orthotopic liver transplantation.American Journal of Gastroenterology.  96:833-837. 2001
2001 Combined cardiac surgery and liver transplantation.Liver Transplantation and Surgery.  7:60-61. 2001
2001 Safety of endoscopy in patients with end-stage liver disease.Gastrointestinal Endoscopy Clinics of North America.  11:111-130. 2001
2000 Hepatocellular carcinoma presenting with chronic inflammatory demyelinating polyradiculoneuropathy.Digestive Diseases and Sciences.  45:2369-2373. 2000
2000 The safety and efficacy of a two-dose daclizumab (zenapax) induction therapy in liver transplant recipients.Transplantation.  69:1867-1872. 2000
2000 Liver transplantation in the era of cost constraints.Southern Medical Journal.  93:392-396. 2000
2000 Role of ERCP in asymptomatic orthotopic liver transplant patients with abnormal liver enzymesAmerican Journal of Gastroenterology.  95:141-144. 2000
1999 Hepatopulmonary syndrome and venous emboli causing intracerebral hemorrhages after liver transplantation: a case report.Transplantation.  68:1809-1811. 1999
1998 Race: a critical factor in organ donation, patient referral and selection, and orthotopic liver transplantation?Liver Transplantation and Surgery.  4:499-505. 1998
1998 Complications of cirrhosis. Why they occur and what to do about them.Postgraduate Medicine.  103:209-224. 1998
1998 Tacrolimus (FK506) and mycophenolate mofetil combination therapy versus tacrolimus in adult liver transplantation.Transplantation.  65:180-187. 1998
1997 Race is not a critical factor in orthotopic liver transplantation.Transplantation Proceedings.  29:3729-3730. 1997
1997 Small-cell carcinoma of the lung manifesting as acute hepatic failure.Mayo Clinic Proceedings.  72:133-139. 1997
1995 Review of support systems used in the management of fulminant hepatic failure.Digestive Diseases.  13:379-388. 1995
1995 Gel-entrapment bioartificial liver therapy in galactosamine hepatitis.Journal of Surgical Research.  59:179-184. 1995
1995 Celiac sprue in an asymptomatic elderly man.Minnesota Medicine.  78:29-30. 1995

Research Overview

  • Cirrhosis
    Hepatic encephalopathy
    Acute liver failure
  • Principal Investigator On

  • Private Grant  awarded by Gilead Sciences 2015 - 2021
  • ALFSG - Potential Use of Rotational Thromboelastometry to Explore Hemostatic Abnormalities in Patients with Acute Liver Failure (ROTEM)  awarded by University of Texas Southwestern Medical Center at Dallas 2016 - 2020
  • Acute Liver Failure Study Group 13C- Methacetin Breath Test for the Prediction of Acute Liver Failure  awarded by University of Texas Southwestern Medical Center at Dallas 2016 - 2020
  • A Multi-Center Group to Study Acute Liver Failure Grant Renewal RE: U01-DK 09-506  awarded by University of Texas Southwestern Medical Center at Dallas 2015 - 2020
  • Private Grant  awarded by MALLINCKRODT, INC. 2017 - 2020
  • Porphyria Rare Disease Clinical Research Consortium (RDCRC)  awarded by Mount Sinai School of Medicine 2018 - 2019
  • Private Grant  awarded by EISAI, INC. 2016 - 2019
  • A Phase 2A Study to Evaluate the Safety and Tolerability of OCR-002 (Ornithine Phenylacetate) in the Treatment of Patients with Acute Liver Failure/Severe Acute Liver Injury (STOP-ALF)  awarded by University of Texas Southwestern Medical Center at Dallas 2015 - 2016
  • Private Grant  awarded by F.Hoffmann-La Roche Ltd. 2012 - 2016
  • Private Grant  awarded by SALIX PHARMACEUTICALS, INC. 2013 - 2015
  • Private Grant  awarded by SALIX PHARMACEUTICALS, INC. 2013 - 2015
  • A Multicenter Group to Study Acute Liver Failure  awarded by University of Texas Southwestern Medical Center at Dallas 2010 - 2015
  • Private Grant  awarded by OCERA THERAPEUTICS, INC. 2013 - 2014
  • Private Grant  awarded by SALIX PHARMACEUTICALS, INC. 2013 - 2014
  • Private Grant  awarded by VERTEX PHARMACEUTICALS, INC. 2012 - 2014
  • Private Grant  awarded by VITAL THERAPIES, INC 2013 - 2014
  • Private Grant  awarded by VITAL THERAPIES, INC 2012 - 2014
  • Private Grant  awarded by IKARIA 2011 - 2014
  • Private Grant  awarded by Bayer HealthCare 2008 - 2014
  • Private Grant  awarded by HEMCON MEDICAL TECHNOLOGIES, INC. 2012 - 2014
  • Private Grant  awarded by F.Hoffmann-La Roche Ltd. 2009 - 2013
  • Private Grant  awarded by OTSUKA PHARMACEUTICAL DEVELOPMENT & COMMERCIALIZATION, INC 2012 - 2013
  • Private Grant  awarded by CUMBERLAND PHARMACEUTICALS, INC. 2011 - 2013
  • Private Grant  awarded by OCERA THERAPEUTICS, INC. 2008 - 2013
  • Private Grant  awarded by OCERA THERAPEUTICS, INC. 2009 - 2013
  • Private Grant  awarded by VITAL THERAPIES, INC 2009 - 2013
  • Private Grant  awarded by HYPERION THERAPEUTICS, INC. 2009 - 2012
  • Private Grant  awarded by SC LIVER RESEARCH CONSORTIUM 2009 - 2012
  • Private Grant  awarded by HYPERION THERAPEUTICS, INC. 2008 - 2012
  • Assessment of the Efficacy of Pioglitazone on Viral Kinetics, Cytokines, and Innate Immunity in a Group of Insulin Resistant, Treatment Naïve, Chronic Hepatitis C, Genotype 1 Patients  awarded by GENEVA FOUNDATION 2009 - 2011
  • Private Grant  awarded by SALIX PHARMACEUTICALS, INC. 2007 - 2010
  • Investigator On

  • Private Grant  awarded by SC LIVER RESEARCH CONSORTIUM 2017 - 2024
  • Private Grant  awarded by ALLERGAN SALES, LLC 2018 - 2023
  • Private Grant  awarded by CONATUS PHARMACEUTICALS, INC. 2017 - 2021
  • Private Grant  awarded by ALNYLAM PHARMACEUTICALS, INC. 2018 - 2021
  • Private Grant  awarded by CONATUS PHARMACEUTICALS, INC. 2016 - 2020
  • Private Grant  awarded by INTERCEPT PHARMACEUTICALS 2016 - 2020
  • Alabama Coalition for Testing, Interventions and Engagement in Hepatitis C Care (ACTIVE-Care)  awarded by GILEAD FOUNDATION 2017 - 2019
  • Porphyria Rare Disease Clinical Research Consortium (RDCRC)  awarded by Mount Sinai School of Medicine 2017 - 2018
  • Private Grant  awarded by SC LIVER RESEARCH CONSORTIUM 2016 - 2018
  • Private Grant  awarded by SYNAGEVA BIOPHARMA CORP. 2014 - 2017
  • Alabama Coalition for Testing, Interventions, and Engagement in Hepatitis C Care (ACTIVE-Care)  awarded by GILEAD FOUNDATION 2015 - 2017
  • Porphyria Rare Disease Clinical Research Consortium (RDCRC)  awarded by Mount Sinai School of Medicine 2014 - 2017
  • Private Grant  awarded by Gilead Sciences 2012 - 2017
  • Private Grant  awarded by Gilead Sciences 2012 - 2017
  • Alabama Coalition for Testing, Interventions, and Engagement in Hepatitis C Care (ACTIVE-Care)  awarded by GILEAD FOUNDATION 2015 - 2016
  • Private Grant  awarded by CONATUS PHARMACEUTICALS, INC. 2014 - 2016
  • Private Grant  awarded by Gilead Sciences 2012 - 2016
  • UAB Inpatient Procedure Service  awarded by UNIVERSITY OF ALABAMA HEALTH SERVICES FOUNDATION 2013 - 2015
  • Private Grant  awarded by CONATUS PHARMACEUTICALS, INC. 2014
  • Porphyria Rare Disease Clinical Research Consortium (RDCRC)  awarded by Mount Sinai School of Medicine 2009 - 2014
  • Private Grant  awarded by BRISTOL MYERS SQUIBB PHARMACEUTICAL COMPANY 2012 - 2014
  • Private Grant  awarded by Genentech 2012 - 2014
  • Private Grant  awarded by CLINUVEL PHARMACEUTICALS LTD 2012 - 2014
  • Private Grant  awarded by BRACCO DIAGNOSTICS, INC. 2010 - 2013
  • Private Grant  awarded by ABBVIE INC 2013
  • Education And Training

  • Doctor of Medicine, University of Pittsburgh
  • ALABAMA MEDICAL LICENSURE COMMISSION, Internship 1991
  • ALABAMA MEDICAL LICENSURE COMMISSION, Residency 1993
  • ALABAMA MEDICAL LICENSURE COMMISSION, Postdoctoral Fellowship 1996
  • Full Name

  • Brendan McGuire