Positions

Selected Publications

Academic Article

Year Title Altmetric
2019 Hepatocellular carcinoma surveillance: An evidence-based approachWorld Journal of Gastroenterology.  25:1550-1559. 2019
2019 Case series regarding parastomal variceal bleeding: Presentation and managementAnnals of hepatology.  18:250-257. 2019
2017 The Natural History of Severe Acute Liver InjuryAmerican Journal of Gastroenterology.  112:1389-1396. 2017
2017 Current guidelines for chemoembolization for hepatocellular carcinoma: Room for improvement?Hepatology Communications.  1:338-346. 2017
2017 Association of Variants of Arginine Vasopressin and Arginine Vasopressin Receptor 1A With Severe Acetaminophen Liver InjuryCellular and Molecular Gastroenterology and Hepatology.  3:500-505. 2017
2017 Primary biliary cirrhosis has high wait-list mortality among patients listed for liver transplantationTransplant International.  30:454-462. 2017
2017 Heat stroke leading to acute liver injury & failure: A case series from the Acute Liver Failure Study GroupLiver International.  37:509-513. 2017
2017 Sorafenib use for recurrent hepatocellular cancer after resection or transplantation: Observations from a US regional analysis of the GIDEON registryAmerican Journal of Surgery.  213:688-695. 2017
2017 Unusually High Rates of Hepatocellular Carcinoma After Treatment With Direct-Acting Antiviral Therapy for Hepatitis C Related CirrhosisGastroenterology.  152:911-912. 2017
2017 A SEER Database Analysis of the Survival Advantage of Transarterial Chemoembolization for Hepatocellular Carcinoma: An Underutilized TherapyJVIR: Journal of Vascular and Interventional Radiology.  28:231-237.e2. 2017
2017 HBV-Associated Acute Liver Failure After Immunosuppression and Risk of DeathClinical Gastroenterology and Hepatology.  15:113-122. 2017
2017 Orthotopic liver transplantation changes the course of gastric antral vascular ectasia: A case series from a transplant centerEuropean Journal of Gastroenterology and Hepatology.  29:973-976. 2017
2016 Acute liver injury and acute liver failure from mushroom poisoning in North AmericaLiver International.  36:1043-1050. 2016
2016 Outcomes in adults with acute liver failure between 1998 and 2013: An observational cohort studyAnnals of Internal Medicine.  164:724-732. 2016
2016 Terlipressin Plus Albumin Is More Effective Than Albumin Alone in Improving Renal Function in Patients with Cirrhosis and Hepatorenal Syndrome Type 1Gastroenterology.  150:1579-1589.e2. 2016
2016 Association Between Plasma Level of Galectin-9 and Survival of Patients With Drug-Induced Acute Liver FailureClinical Gastroenterology and Hepatology.  14:606-612.e3. 2016
2015 Detection of ophthalmic acid in serum from acetaminophen-induced acute liver failure patients is more frequent in non-survivorsPLoS ONE.  10. 2015
2015 Procalcitonin identifies cell injury, not bacterial infection, in acute liver failurePLoS ONE.  10. 2015
2015 Diagnosis and Management of Hepatic Encephalopathy in Fulminant Hepatic FailureClinics in Liver Disease.  19:565-576. 2015
2015 Plasma osteopontin in acute liver failureCytokine.  73:270-276. 2015
2015 Impact of all oral anti-hepatitis C virus therapy: A meta-analysisWorld Journal of Hepatology.  7:806-813. 2015
2015 Liver transplantation for alcoholic hepatitis: A survey of liver transplant centersLiver Transplantation and Surgery.  21:1449-1452. 2015
2015 Screening and Detection of Hepatocellular CarcinomaClinics in Liver Disease.  19:295-307. 2015
2014 Gastric Antral Vascular Ectasia: A Rare Manifestation for Gastrointestinal Bleeding in Left Ventricular Assist Device Patients—An Initial ReportDigestive Diseases and Sciences.  59:2826-2830. 2014
2014 A pilot study examining the safety and tolerability of valacyclovir in veterans with hepatitis c virus/herpes simplex virus type 2 coinfectionAmerican Journal of the Medical Sciences2014
2014 Detection of anti-isoniazid and anti-cytochrome P450 antibodies in patients with isoniazid-induced liver failureHepatology.  59:1084-1093. 2014
2014 Steroid use in acute liver failureHepatology.  59:612-621. 2014
2014 Liver transplantation in the management of porphyriaHepatology.  60:1082-1089. 2014
2014 Micro-RNA-122 levels in acute liver failure and chronic hepatitis CJournal of Medical Virology.  86:1507-1514. 2014
2014 Safety and yield of diagnostic ERCP in liver transplant patients with abnormal liver function testsDiagnostic and Therapeutic Endoscopy.  2014. 2014
2014 Surveillance for hepatocellular carcinoma: Evidence, guidelines and utilizationAmerican Journal of the Medical Sciences.  347:415-419. 2014
2013 Double-balloon enteroscopy-ERCP rendezvous techniqueEndoscopy.  45. 2013
2013 Quality of life is significantly impaired in long-term survivors of acute liver failure and particularly in acetaminophen-overdose patientsLiver Transplantation and Surgery.  19:991-1000. 2013
2013 Percutaneous balloon dilation and placement of endoscopic biliary stent by using the double-balloon enteroscopy ERCP rendezvous techniqueGastrointestinal Endoscopy.  78:383-385. 2013
2012 Telaprevir and boceprevir in African Americans with genotype 1 chronic hepatitis C: Implications for patients and providersSouthern Medical Journal.  105:431-436. 2012
2012 Equivalent survival following liver transplantation in patients with non-alcoholic steatohepatitis compared with patients with other liver diseasesHPB.  14:625-634. 2012
2011 A biopsychosocial approach to liver transplant evaluation in two patients with Wilson's diseasePsychology, Health and Medicine.  16:268-275. 2011
2011 Comparing the aspartate aminotransferase (AST) to platelet ratio index (APRI) between African American and white veterans with chronic hepatitis CSouthern Medical Journal.  104:309-314. 2011
2010 Pharmacology and safety of glycerol phenylbutyrate in healthy adults and adults with cirrhosisHepatology.  51:2077-2085. 2010
2010 Autoimmune hepatitis-primary sclerosing cholangitis overlap syndrome complicated by Crohn's diseaseDigestion.  82:24-26. 2010
2009 Current trends in the treatment of hepatic encephalopathyTherapeutics and Clinical Risk Management.  5:617-626. 2009
2009 Pharmacokinetics of tacrolimus co-administered with adefovir dipivoxil to liver transplant recipientsLiver International.  29:1178-1183. 2009
2009 Outcome of acute liver failure in the elderlyLiver Transplantation and Surgery.  15:1481-1487. 2009
2009 Long-term management of the liver transplant patient: Recommendations for the primary care doctor: Special featureAmerican Journal of Transplantation.  9:1988-2003. 2009
2009 Current trends in the treatment of hepatic encephalopathy.Therapeutics and Clinical Risk Management.  5:617-626. 2009
2009 Editorial commentCurrent Opinion in Organ Transplantation.  14:219-220. 2009
2009 Editorial introductionsCurrent Opinion in Organ Transplantation.  14. 2009
2009 Performance of the hepatic encephalopathy scoring algorithm in a clinical trial of patients with cirrhosis and severe hepatic encephalopathyAmerican Journal of Gastroenterology.  104:1392-1400. 2009
2009 The role of etiology in the hyperamylasemia of acute liver failureAmerican Journal of Gastroenterology.  104:592-597. 2009
2009 Hepatic assist devices: Will they ever be successful?Current Gastroenterology Reports.  11:64-68. 2009
2009 HFE hemochromatosis and hepatic sarcoidAmerican Journal of the Medical Sciences.  337:386-390. 2009
2008 Detection and diagnosis of herpes simplex virus infection in adults with acute liver failureLiver Transplantation and Surgery.  14:1498-1504. 2008
2008 Screening for Wilson disease in acute liver failure: A comparison of currently available diagnostic testsHepatology.  48:1167-1174. 2008
2008 The coagulopathy of acute liver failure and implications for intracranial pressure monitoringNeurocritical Care.  9:103-107. 2008
2007 Electrophoretic methods for analysis of urinary polypeptides in lgA-associated renal diseasesELECTROPHORESIS.  28:4469-4483. 2007
2007 Randomized controlled study of extracorporeal albumin dialysis for hepatic encephalopathy in advanced cirrhosisHepatology.  46:1853-1862. 2007
2007 Antimitochondrial antibodies in acute liver failure: Implications for primary biliary cirrhosisHepatology.  46:1436-1442. 2007
2007 {A figure is presented}Intermittent Unexplained Abdominal Pain: Is It Porphyria?Clinical Gastroenterology and Hepatology.  5:1255-1258. 2007
2007 Urinary biomarkers of IgA nephropathy and other IgA-associated renal diseasesWorld Journal of Urology.  25:467-476. 2007
2007 Predictive value of actin-free Gc-globulin in acute liver failureLiver Transplantation and Surgery.  13:1324-1329. 2007
2007 Retransplantation for hepatitis C: Results of a U.S. multicenter retransplant studyLiver Transplantation and Surgery.  13:1246-1253. 2007
2007 Elevated troponin I levels in acute liver failure: Is myocardial injury an integral part of acute liver failure?Hepatology.  45:1489-1495. 2007
2007 Use of extracorporeal albumin dialysis for erythropoietic protoporphyriaLiver Transplantation and Surgery.  13:639-640. 2007
2007 Intensive care of patients with acute liver failure: Recommendations of the U.S. Acute Liver Failure Study GroupCritical Care Medicine.  35:2498-2508. 2007
2006 Alpha-fetoprotein and prognosis in acute liver failureLiver Transplantation and Surgery.  12:1776-1781. 2006
2006 Fulminant hepatitis A virus infection in the United States: Incidence, prognosis, and outcomesHepatology.  44:1589-1597. 2006
2006 Hepatic encephalopathy: A review of its pathophysiology and treatmentCurrent Treatment Options in Gastroenterology.  9:464-474. 2006
2006 Detection of acetaminophen protein adducts in children with acute liver failure of indeterminate causePediatrics (Spanish Edition).  118. 2006
2006 Outpatient management of cirrhosis: A narrative reviewSouthern Medical Journal.  99:600-606. 2006
2006 Brief communication: Glomerulonephritis in patients with hepatitis C cirrhosis undergoing liver transplantationAnnals of Internal Medicine.  144:735-741. 2006
2006 Acute liver failure in children: The first 348 patients in the pediatric acute liver failure study groupJournal of Pediatrics.  148. 2006
2005 Liver transplantation for erythropoietic protoporphyria liver diseaseLiver Transplantation and Surgery.  11:1590-1596. 2005
2005 Gc-globulin and prognosis in acute liver failureLiver Transplantation and Surgery.  11:1223-1227. 2005
2004 Two-dose daclizumab induction therapy in 209 liver transplants: A single-center analysisTransplantation.  78:1212-1217. 2004
2004 Prospective, Randomized, Multicenter, Controlled Trial of a Bioartificial Liver in Treating Acute Liver FailureAnnals of Surgery.  239:660-670. 2004
2003 Influence of hepatic encephalopathy on health-related quality of life in patients with cirrhosisDigestive Diseases and Sciences.  48:1622-1626. 2003
2003 Viral hepatitis-related acute liver failureAmerican Journal of Gastroenterology.  98:448-453. 2003
2003 The critically ill liver patient: Fulminant hepatic failureSeminars in Gastrointestinal Disease.  14:39-42. 2003
2002 Results of a prospective study of acute liver failure at 17 tertiary care centers in the United StatesAnnals of Internal Medicine.  137:947-954. 2002
2002 A pilot study of interferon alfa and ribavirin combination in liver transplant recipients with recurrent hepatitis CHepatology.  36:1253-1258. 2002
2002 Impact of noncompliance and donor/recipient race matching on chronic liver rejectionTransplantation Proceedings.  34:1497-1498. 2002
2002 Use of preserved vascular homografts in liver transplantation: Hepatic artery aneurysms and other complicationsAmerican Journal of Transplantation.  2:471-475. 2002
2002 Implementation of vaccination in patients with cirrhosisDigestive Diseases and Sciences.  47:384-387. 2002
2001 The use of screening and preventive therapies for gastroesophageal varices in patients referred for evaluation of orthotopic liver transplantationAmerican Journal of Gastroenterology.  96:833-837. 2001
2001 The use of screening and preventive therapies for gastroesophageal varices in patients referred for evaluation of orthotopic liver transplantation.American Journal of Gastroenterology.  96:833-837. 2001
2001 Safety of endoscopy in patients with end-stage liver diseaseGastrointestinal Endoscopy Clinics of North America.  11:111-130. 2001
2001 Combined cardiac surgery and liver transplantationLiver Transplantation and Surgery.  7:60-61. 2001
2000 Hepatocellular carcinoma presenting with chronic inflammatory demyelinating polyradiculoneuropathyDigestive Diseases and Sciences.  45:2369-2373. 2000
2000 The safety and efficacy of a two-dose daclizumab (Zenapax) induction therapy in liver transplant recipientsTransplantation.  69:1867-1872. 2000
2000 Liver transplantation in the era of cost constraintsSouthern Medical Journal.  93:392-396. 2000
2000 Role of ERCP in asymptomatic orthotopic liver transplant patients with abnormal liver enzymesAmerican Journal of Gastroenterology.  95:141-144. 2000
1999 Hepatopulmonary syndrome and venous emboli causing intracerebral hemorrhages after liver transplantation: A case reportTransplantation.  68:1809-1811. 1999
1998 Tacrolimus (FK506) and mycophenolate mofetil combination therapy versus tacrolimus in adult liver transplantationTransplantation.  65:180-187. 1998
1998 Complications of cirrhosis: Why they occur and what to do about themPostgraduate Medicine.  103:209-224. 1998
1998 Race: A critical factor in organ donation, patient referral and selection, and orthotopic liver transplantation?Liver Transplantation and Surgery.  4:499-505. 1998
1997 Race is not a critical factor in orthotopic liver transplantation.Transplantation Proceedings.  29:3729-3730. 1997
1997 Small-cell carcinoma of the lung manifesting as acute hepatic failureMayo Clinic Proceedings.  72:133-139. 1997
1995 Celiac sprue in an asymptomatic elderly man.Minnesota Medicine.  78:29-30. 1995
1995 Gel-entrapment bioartificial liver therapy in galactosamine hepatitisJournal of Surgical Research.  59:179-184. 1995
1995 Review of support systems used in the management of fulminant hepatic failureDigestive Diseases.  13:379-388. 1995

Research Overview

  • Cirrhosis
    Hepatic encephalopathy
    Acute liver failure
  • Principal Investigator On

  • Private Grant  awarded by Gilead Sciences 2015 - 2021
  • ALFSG - Potential Use of Rotational Thromboelastometry to Explore Hemostatic Abnormalities in Patients with Acute Liver Failure (ROTEM)  awarded by University of Texas Southwestern Medical Center at Dallas 2016 - 2020
  • Acute Liver Failure Study Group 13C- Methacetin Breath Test for the Prediction of Acute Liver Failure  awarded by University of Texas Southwestern Medical Center at Dallas 2016 - 2020
  • A Multi-Center Group to Study Acute Liver Failure Grant Renewal RE: U01-DK 09-506  awarded by University of Texas Southwestern Medical Center at Dallas 2015 - 2020
  • Private Grant  awarded by MALLINCKRODT, INC. 2017 - 2020
  • Porphyria Rare Disease Clinical Research Consortium (RDCRC)  awarded by Mount Sinai School of Medicine 2018 - 2019
  • Private Grant  awarded by EISAI, INC. 2016 - 2017
  • A Phase 2A Study to Evaluate the Safety and Tolerability of OCR-002 (Ornithine Phenylacetate) in the Treatment of Patients with Acute Liver Failure/Severe Acute Liver Injury (STOP-ALF)  awarded by University of Texas Southwestern Medical Center at Dallas 2015 - 2016
  • Private Grant  awarded by F.Hoffmann-La Roche Ltd. 2012 - 2016
  • Private Grant  awarded by SALIX PHARMACEUTICALS, INC. 2013 - 2015
  • Private Grant  awarded by SALIX PHARMACEUTICALS, INC. 2013 - 2015
  • A Multicenter Group to Study Acute Liver Failure  awarded by University of Texas Southwestern Medical Center at Dallas 2010 - 2015
  • Private Grant  awarded by OCERA THERAPEUTICS, INC. 2013 - 2014
  • Private Grant  awarded by SALIX PHARMACEUTICALS, INC. 2013 - 2014
  • Private Grant  awarded by VERTEX PHARMACEUTICALS, INC. 2012 - 2014
  • Private Grant  awarded by VITAL THERAPIES, INC 2013 - 2014
  • Private Grant  awarded by VITAL THERAPIES, INC 2012 - 2014
  • Private Grant  awarded by IKARIA 2011 - 2014
  • Private Grant  awarded by Bayer HealthCare 2008 - 2014
  • Private Grant  awarded by HEMCON MEDICAL TECHNOLOGIES, INC. 2012 - 2014
  • Private Grant  awarded by F.Hoffmann-La Roche Ltd. 2009 - 2013
  • Private Grant  awarded by OTSUKA PHARMACEUTICAL DEVELOPMENT & COMMERCIALIZATION, INC 2012 - 2013
  • Private Grant  awarded by CUMBERLAND PHARMACEUTICALS, INC. 2011 - 2013
  • Private Grant  awarded by OCERA THERAPEUTICS, INC. 2008 - 2013
  • Private Grant  awarded by OCERA THERAPEUTICS, INC. 2009 - 2013
  • Private Grant  awarded by VITAL THERAPIES, INC 2009 - 2013
  • Private Grant  awarded by HYPERION THERAPEUTICS, INC. 2009 - 2012
  • Private Grant  awarded by SC LIVER RESEARCH CONSORTIUM 2009 - 2012
  • Private Grant  awarded by HYPERION THERAPEUTICS, INC. 2008 - 2012
  • Assessment of the Efficacy of Pioglitazone on Viral Kinetics, Cytokines, and Innate Immunity in a Group of Insulin Resistant, Treatment Naïve, Chronic Hepatitis C, Genotype 1 Patients  awarded by GENEVA FOUNDATION 2009 - 2011
  • Private Grant  awarded by SALIX PHARMACEUTICALS, INC. 2007 - 2010
  • Investigator On

  • Private Grant  awarded by SC LIVER RESEARCH CONSORTIUM 2017 - 2024
  • Private Grant  awarded by ALLERGAN SALES, LLC 2018 - 2023
  • Private Grant  awarded by INTERCEPT PHARMACEUTICALS 2019 - 2023
  • Private Grant  awarded by CONATUS PHARMACEUTICALS, INC. 2017 - 2021
  • Private Grant  awarded by ALNYLAM PHARMACEUTICALS, INC. 2018 - 2021
  • Private Grant  awarded by CONATUS PHARMACEUTICALS, INC. 2016 - 2020
  • Alabama Coalition for Testing, Interventions and Engagement in Hepatitis C Care (ACTIVE-Care)  awarded by GILEAD FOUNDATION 2017 - 2019
  • Porphyria Rare Disease Clinical Research Consortium (RDCRC)  awarded by Mount Sinai School of Medicine 2017 - 2018
  • Private Grant  awarded by INTERCEPT PHARMACEUTICALS 2016 - 2018
  • Private Grant  awarded by SC LIVER RESEARCH CONSORTIUM 2016 - 2018
  • Private Grant  awarded by SYNAGEVA BIOPHARMA CORP. 2014 - 2017
  • Alabama Coalition for Testing, Interventions, and Engagement in Hepatitis C Care (ACTIVE-Care)  awarded by GILEAD FOUNDATION 2015 - 2017
  • Porphyria Rare Disease Clinical Research Consortium (RDCRC)  awarded by Mount Sinai School of Medicine 2014 - 2017
  • Private Grant  awarded by Gilead Sciences 2012 - 2017
  • Private Grant  awarded by Gilead Sciences 2012 - 2017
  • Alabama Coalition for Testing, Interventions, and Engagement in Hepatitis C Care (ACTIVE-Care)  awarded by GILEAD FOUNDATION 2015 - 2016
  • Private Grant  awarded by CONATUS PHARMACEUTICALS, INC. 2014 - 2016
  • Private Grant  awarded by Gilead Sciences 2012 - 2016
  • UAB Inpatient Procedure Service  awarded by UNIVERSITY OF ALABAMA HEALTH SERVICES FOUNDATION 2013 - 2015
  • Private Grant  awarded by CONATUS PHARMACEUTICALS, INC. 2014
  • Porphyria Rare Disease Clinical Research Consortium (RDCRC)  awarded by Mount Sinai School of Medicine 2009 - 2014
  • Private Grant  awarded by BRISTOL MYERS SQUIBB PHARMACEUTICAL COMPANY 2012 - 2014
  • Private Grant  awarded by Genentech 2012 - 2014
  • Private Grant  awarded by CLINUVEL PHARMACEUTICALS LTD 2012 - 2014
  • Private Grant  awarded by BRACCO DIAGNOSTICS, INC. 2010 - 2013
  • Private Grant  awarded by ABBVIE INC 2013
  • Education And Training

  • Doctor of Medicine, University of Pittsburgh 1990
  • ALABAMA MEDICAL LICENSURE COMMISSION, Internship 1991
  • ALABAMA MEDICAL LICENSURE COMMISSION, Residency 1993
  • ALABAMA MEDICAL LICENSURE COMMISSION, Postdoctoral Fellowship 1996
  • Full Name

  • Brendan McGuire