Positions

Overview

  • Dr. Hanaoka is conducting clinical studies to understand the reasons behind the decline in skeletal muscle function and physical activity in patients with rheumatic diseases, particularly in rheumatoid arthritis (RA). Her research is primarily focused on understanding at a mechanistic level the metabolic and physiologic abnormalities of skeletal muscle in RA patients. More specifically, she is investigating if insulin resistance is an underlying cause of skeletal muscle dysfunction in RA patients by conducting clinical trials utilizing an insulin sensitizer. This research is being supported by a K23 NIAMS patient-oriented career development award. Dr. Hanaoka is also conducting additional collaborative studies with her husband, Dr. Prabha Nagareddy (UAB - Nutrition Sciences), and Dr. Andrew Murphy (Baker IDI Institute, Melbourne, Australia) to examine the molecular pathways that contribute to increased cardiovascular disease risk in RA patients.
  • Selected Publications

    Academic Article

    Year Title Altmetric
    2019 Chronic Inflammation in Rheumatoid Arthritis and Mediators of Skeletal Muscle Pathology and Physical Impairment: A ReviewArthritis Care and Research.  71:173-177. 2019
    2018 Defective cholesterol metabolism in haematopoietic stem cells promotes monocyte-driven atherosclerosis in rheumatoid arthritisEuropean Heart Journal.  39:2158-2167. 2018
    2018 Secretory sphingomyelinase (S-SMase) activity is elevated in patients with rheumatoid arthritisClinical Rheumatology.  37:1395-1399. 2018
    2015 Does computed tomography-based muscle density predict muscle function and health-related quality of life in patients with idiopathic inflammatory myopathies?Arthritis Care and Research.  67:1031-1040. 2015
    2014 Physical impairment in patients with idiopathic inflammatory myopathies is associated with the American College of Rheumatology functional status measureClinical Rheumatology.  34:1929-1937. 2014
    2012 Glucocorticoid effects on skeletal muscle: Benefit and risk in patients with autoimmune inflammatory rheumatoid diseasesExpert Review of Clinical Immunology.  8:695-697. 2012
    2012 Implications of glucocorticoid therapy in idiopathic inflammatory myopathiesNature Reviews Rheumatology.  8:448-457. 2012
    2008 Peripheral mononeuropathy with etanercept use: Case report [4]Journal of Rheumatology.  35:182-183. 2008
    2004 Animal model-based strategy of palpebral surgery trainingArquivos Brasileiros de Oftalmologia.  67:437-440. 2004

    Education And Training

  • Doctor of Medicine, University of Sao Paulo 2004
  • Cleveland Clinic Foundation, Residency 2008
  • Columbia University, Postdoctoral Fellowship 2010
  • Full Name

  • Beatriz Hanaoka