Positions

Selected Publications

Academic Article

Year Title Altmetric
2020 Generation of retinaldehyde for retinoic acid biosynthesisBiomolecules.  10. 2020
2019 Generation of Retinaldehyde for Retinoic Acid Biosynthesis 2019
2019 Mice lacking the epidermal retinol dehydrogenases SDR16C5 and SDR16C6 display accelerated hair growth and enlarged meibomian glandsJournal of Biological Chemistry.  294:17060-17074. 2019
2019 17-Beta Hydroxysteroid Dehydrogenase 13 Is a Hepatic Retinol Dehydrogenase Associated With Histological Features of Nonalcoholic Fatty Liver DiseaseHepatology.  69:1504-1519. 2019
2019 Retinyl esters are elevated in progeny of retinol dehydrogenase 11 deficient damsChemico-Biological Interactions.  302:117-122. 2019
2018 Retinol dehydrogenase 11 is essential for the maintenance of retinol homeostasis in liver and testis in miceJournal of Biological Chemistry.  293:6996-7007. 2018
2017 Characterization of human short chain dehydrogenase/reductase SDR16C family members related to retinol dehydrogenase 10Chemico-Biological Interactions.  276:88-94. 2017
2017 The antagonistically bifunctional retinoid oxidoreductase complex is required for maintenance of all-trans-retinoic acid homeostasisJournal of Biological Chemistry.  292:5884-5897. 2017
2016 Coelimination and Survival in Gene Network Evolution: Dismantling the RA-Signaling in a ChordateMolecular Biology and Evolution.  33:2401-2416. 2016
2016 Retinoid X receptor agonists upregulate genes responsible for the biosynthesis of all-trans-retinoic acid in human epidermisPLoS ONE.  11. 2016
2015 Evolutionary origins of retinoid active short-chain dehydrogenases/reductases of SDR16C familyChemico-Biological Interactions.  234:135-143. 2015
2014 The retinaldehyde reductase activity of dhrs3 is reciprocally activated by retinol dehydrogenase 10 to control retinoid homeostasisJournal of Biological Chemistry.  289:14868-14880. 2014
2012 Short chain dehydrogenase/reductase Rdhe2 is a novel retinol dehydrogenase essential for frog embryonic developmentJournal of Biological Chemistry.  287:9061-9071. 2012
2011 Evidence that proteosome inhibitors and chemical chaperones can rescue the activity of retinol dehydrogenase 12 mutant T49MChemico-Biological Interactions.  191:55-59. 2011
2011 Retinol dehydrogenase 10 but not retinol/sterol dehydrogenase(s) regulates the expression of retinoic acid-responsive genes in human transgenic skin raft cultureJournal of Biological Chemistry.  286:13550-13560. 2011
2010 Disease-associated variants of microsomal retinol dehydrogenase 12 (RDH12) are degraded at mutant-specific ratesFEBS Letters.  584:507-510. 2010
2009 Identification and characterization of retinoid-active short-chain dehydrogenases/reductases in Drosophila melanogaster 2009
2009 Biochemical characterization of human epidermal retinol dehydrogenase 2Chemico-Biological Interactions.  178:182-187. 2009
2009 Lipoprotein particles of intraocular origin in human bruch membrane: An unusual lipid profileInvestigative Ophthalmology and Visual Science.  50:870-877. 2009
2008 Kinetic analysis of human enzyme RDH10 defines the characteristics of a physiologically relevant retinol dehydrogenaseJournal of Biological Chemistry.  283:20299-20308. 2008
2008 Effect of lipid peroxidation products on the activity of human retinol dehydrogenase 12 (RDH12) and retinoid metabolism 2008
2008 Human retinol dehydrogenase 13 (RDH13) is a mitochondrial short-chain dehydrogenase/reductase with a retinaldehyde reductase activity 2008
2007 Overproduction of bioactive retinoic acid in cells expressing disease-associated mutants of retinol dehydrogenase 12Journal of Biological Chemistry.  282:35621-35628. 2007
2007 Role of microsomal retinol/sterol dehydrogenase-like short-chain dehydrogenases/reductases in the oxidation and epimerization of 3α-hydroxysteroids in human tissuesEndocrinology.  148:2148-2156. 2007
2006 Comparative genomic and phylogenetic analysis of short-chain dehydrogenases/reductases with dual retinol/sterol substrate specificityGenomics.  88:820-830. 2006
2006 Comparative functional analysis of human medium-chain dehydrogenases, short-chain dehydrogenases/reductases and aldo-keto reductases with retinoidsBiochemical Journal.  399:101-109. 2006
2005 Biochemical properties of purified human retinol dehydrogenase 12 (RDH 12): Catalytic efficiency toward retinoids and C9 aldehydes and effects of cellular retinol-binding protein type I (CRBPI) and cellular retinaldehyde-binding protein (CRALBP) on the oxidation and reduction of retinoidsBiochemistry.  44:7035-7047. 2005
2003 Properties of Short-Chain Dehydrogenase/Reductase RalR1: Characterization of Purified Enzyme, Its Orientation in the Microsomal Membrane, and Distribution in Human Tissues and Cell LinesBiochemistry.  42:14838-14845. 2003
2003 Characterization of truncated mutants of human microsomal short-chain dehydrogenase/reductase RoDH-4Chemico-Biological Interactions.  143-144:279-287. 2003
2003 Differential recognition of the free versus bound retinol by human microsomal retinol/sterol dehydrogenases: Characterization of the holo-CRBP dehydrogenase activity of RoDH-4Biochemistry.  42:776-784. 2003
2003 Mitochondrial DNA Variations in Russian and Belorussian Populations 2003
2002 Human pancreas protein 2 (PAN2) has a retinal reductase activity and is ubiquitously expressed in human tissuesFEBS Letters.  531:489-493. 2002
2002 Evidence that the human gene for prostate short-chain dehydrogenase/ reductase (PSDR1) encodes a novel retinal reductase (RalR1)Journal of Biological Chemistry.  277:28909-28915. 2002
2001 Polymorphism of hypervariable segment i of mitochondria! dna in three ethnic populations from the volga-ural region 2001
2001 Polymorphism of Hypervariable Segment I of Mitochondrial DNA in Three Ethnic Populations from the Volga-Ural Region 2001
2001 Characterization of a novel type of human microsomal 3α -hydroxysteroid dehydrogenase. Unique tissue distribution and catalytic propertiesJournal of Biological Chemistry.  276:22278-22286. 2001
2001 Cloning of the human RoDH-related short chain dehydrogenase gene and analysis of its structureChemico-Biological Interactions.  130-132:457-467. 2001
1999 Fine mapping of a polymorphic CA repeat marker on human chromosome 19 and its use in population studiesGene.  230:259-266. 1999
1997 New highly polymorphic (CA) marker isoated from a human chromosome 19 libraryMolecular Biology.  31:795-800. 1997
1997 A new highly polymorphic (CA)n marker isolated from a human chromosome 19 libraryMolecular Biology.  31:675-679. 1997

Chapter

Year Title Altmetric
2020 Application of human organotypic skin raft cultures for analysis of retinoid metabolism, retinoic acid signaling, and screening of bioactive rexinoids.  493-512. 2020
2020 Generation and isolation of recombinant retinoid oxidoreductase complex.  77-93. 2020

Research Overview

  • My research interests lie in the area of metabolism of physiologically active compounds, in particular, fat-soluble vitamins and steroid hormones. My research is focused on the enzymes that control interconversion of vitamin A metabolites, and regulate cellular levels of its physiologically active derivatives, such as retinoic acid. I have a particular interest in the evolution of protein families involved in the retinoic acid biosynthesis pathway.
  • Education And Training

  • Doctorate Level Degree in Molecular Genetics, 1998
  • Master's Level Degree in Genetics, Moscow State University named after M.V. Lomonosov 1994
  • Full Name

  • Olga Beliaeva
  • Fax

  • 205-975-2188