Positions

Selected Publications

Academic Article

Year Title Altmetric
2019 17-Beta Hydroxysteroid Dehydrogenase 13 Is a Hepatic Retinol Dehydrogenase Associated With Histological Features of Nonalcoholic Fatty Liver DiseaseHepatology.  69:1504-1519. 2019
2019 Retinyl esters are elevated in progeny of retinol dehydrogenase 11 deficient damsChemico-Biological Interactions.  302:117-122. 2019
2018 Retinol dehydrogenase 11 is essential for the maintenance of retinol homeostasis in liver and testis in miceJournal of Biological Chemistry.  293:6996-7007. 2018
2017 Characterization of human short chain dehydrogenase/reductase SDR16C family members related to retinol dehydrogenase 10Chemico-Biological Interactions.  276:88-94. 2017
2017 The antagonistically bifunctional retinoid oxidoreductase complex is required for maintenance of all-trans-retinoic acid homeostasisJournal of Biological Chemistry.  292:5884-5897. 2017
2016 Coelimination and Survival in Gene Network Evolution: Dismantling the RA-Signaling in a ChordateMolecular Biology and Evolution.  33:2401-2416. 2016
2016 Retinoid X receptor agonists upregulate genes responsible for the biosynthesis of all-trans-retinoic acid in human epidermisPLoS ONE.  11. 2016
2015 Evolutionary origins of retinoid active short-chain dehydrogenases/reductases of SDR16C familyChemico-Biological Interactions.  234:135-143. 2015
2014 The retinaldehyde reductase activity of dhrs3 is reciprocally activated by retinol dehydrogenase 10 to control retinoid homeostasisJournal of Biological Chemistry.  289:14868-14880. 2014
2012 Short chain dehydrogenase/reductase Rdhe2 is a novel retinol dehydrogenase essential for frog embryonic developmentJournal of Biological Chemistry.  287:9061-9071. 2012
2011 Evidence that proteosome inhibitors and chemical chaperones can rescue the activity of retinol dehydrogenase 12 mutant T49MChemico-Biological Interactions.  191:55-59. 2011
2011 Retinol dehydrogenase 10 but not retinol/sterol dehydrogenase(s) regulates the expression of retinoic acid-responsive genes in human transgenic skin raft cultureJournal of Biological Chemistry.  286:13550-13560. 2011
2010 Disease-associated variants of microsomal retinol dehydrogenase 12 (RDH12) are degraded at mutant-specific ratesFEBS Letters.  584:507-510. 2010
2009 Identification and characterization of retinoid-active short-chain dehydrogenases/reductases in Drosophila melanogasterBBA - General Subjects.  1790:1266-1273. 2009
2009 Biochemical characterization of human epidermal retinol dehydrogenase 2Chemico-Biological Interactions.  178:182-187. 2009
2009 Lipoprotein particles of intraocular origin in human bruch membrane: An unusual lipid profileInvestigative Ophthalmology & Visual Science.  50:870-877. 2009
2008 Kinetic analysis of human enzyme RDH10 defines the characteristics of a physiologically relevant retinol dehydrogenaseJournal of Biological Chemistry.  283:20299-20308. 2008
2008 Effect of lipid peroxidation products on the activity of human retinol dehydrogenase 12 (RDH12) and retinoid metabolismBBA - Molecular Basis of Disease.  1782:421-425. 2008
2008 Human retinol dehydrogenase 13 (RDH13) is a mitochondrial short-chain dehydrogenase/reductase with a retinaldehyde reductase activityEuropean Journal of Biochemistry.  275:138-147. 2008
2007 Overproduction of bioactive retinoic acid in cells expressing disease-associated mutants of retinol dehydrogenase 12Journal of Biological Chemistry.  282:35621-35628. 2007
2007 Role of microsomal retinol/sterol dehydrogenase-like short-chain dehydrogenases/reductases in the oxidation and epimerization of 3α-hydroxysteroids in human tissuesEndocrinology.  148:2148-2156. 2007
2006 Comparative genomic and phylogenetic analysis of short-chain dehydrogenases/reductases with dual retinol/sterol substrate specificityGenomics.  88:820-830. 2006
2006 Comparative functional analysis of human medium-chain dehydrogenases, short-chain dehydrogenases/reductases and aldo-keto reductases with retinoidsBiochemical Journal.  399:101-109. 2006
2005 Biochemical properties of purified human retinol dehydrogenase 12 (RDH 12): Catalytic efficiency toward retinoids and C9 aldehydes and effects of cellular retinol-binding protein type I (CRBPI) and cellular retinaldehyde-binding protein (CRALBP) on the oxidation and reduction of retinoidsBiochemistry.  44:7035-7047. 2005
2003 Properties of Short-Chain Dehydrogenase/Reductase RalR1: Characterization of Purified Enzyme, Its Orientation in the Microsomal Membrane, and Distribution in Human Tissues and Cell LinesBiochemistry.  42:14838-14845. 2003
2003 Mitochondrial DNA Variations in Russian and Belorussian PopulationsHuman Biology.  75:647-660. 2003
2003 Characterization of truncated mutants of human microsomal short-chain dehydrogenase/reductase RoDH-4Chemico-Biological Interactions.  143-144:279-287. 2003
2003 Differential recognition of the free versus bound retinol by human microsomal retinol/sterol dehydrogenases: Characterization of the holo-CRBP dehydrogenase activity of RoDH-4Biochemistry.  42:776-784. 2003
2002 Human pancreas protein 2 (PAN2) has a retinal reductase activity and is ubiquitously expressed in human tissuesFEBS Letters.  531:489-493. 2002
2002 Evidence that the human gene for prostate short-chain dehydrogenase/ reductase (PSDR1) encodes a novel retinal reductase (RalR1)Journal of Biological Chemistry.  277:28909-28915. 2002
2001 Polymorphism of hypervariable segment i of mitochondria! dna in three ethnic populations from the volga-ural regionГенетика / Genetika / Russian Journal of Genetics.  37:1118-1124. 2001
2001 Polymorphism of Hypervariable Segment I of Mitochondrial DNA in Three Ethnic Populations from the Volga-Ural RegionГенетика / Genetika / Russian Journal of Genetics.  37:932-938. 2001
2001 Characterization of a novel type of human microsomal 3α -hydroxysteroid dehydrogenase. Unique tissue distribution and catalytic propertiesJournal of Biological Chemistry.  276:22278-22286. 2001
2001 Cloning of the human RoDH-related short chain dehydrogenase gene and analysis of its structureChemico-Biological Interactions.  130-132:457-467. 2001
1999 Fine mapping of a polymorphic CA repeat marker on human chromosome 19 and its use in population studiesGene.  230:259-266. 1999
1997 New highly polymorphic (CA) marker isoated from a human chromosome 19 libraryMolecular Biology.  31:795-800. 1997
1997 A new highly polymorphic (CA)nmarker isolated from a human chromosome 19 libraryMolecular Biology.  31:675-679. 1997

Research Overview

  • My research interests lie in the area of metabolism of physiologically active compounds, in particular, fat-soluble vitamins and steroid hormones. My research is focused on the enzymes that control interconversion of vitamin A metabolites, and regulate cellular levels of its physiologically active derivatives, such as retinoic acid. I have a particular interest in the evolution of protein families involved in the retinoic acid biosynthesis pathway.
  • Education And Training

  • Doctorate Level Degree in Molecular Genetics, 1998
  • Master's Level Degree in Genetics, Moscow State University named after M.V. Lomonosov 1994
  • Full Name

  • Olga Beliaeva
  • Fax

  • 205-975-2188