Positions

Selected Publications

Academic Article

Year Title Altmetric
2018 The luminal domain of the ER stress sensor protein PERK binds misfolded proteins and thereby triggers PERK oligomerizationJournal of Biological Chemistry.  293:4110-4121. 2018
2017 Preliminary X-Ray Crystallographic Studies of the N-Terminal Domains of Hsp104 from Yeast Candida albicans and Saccharomyces cerevisiaeКристаллография / Crystallography Reports.  62:1171-1176. 2017
2017 Crystal structures of Hsp104 N-terminal domains from Saccharomyces cerevisiae and Candida albicans suggest the mechanism for the function of Hsp104 in dissolving prionsActa Crystallographica. Section d, Structural Biology.  73:365-372. 2017
2016 The ER stress sensor PERK luminal domain functions as a molecular chaperone to interact with misfolded proteinsActa Crystallographica. Section d, Structural Biology.  72:1290-1297. 2016
2015 The structure of Tim50(164-361) suggests the mechanism by which Tim50 receives mitochondrial presequencesActa Crystallographica Section F: Structural Biology Communications.  71:1146-1151. 2015
2011 Structural analysis of the Sil1-Bip complex reveals the mechanism for Sil1 to function as a nucleotide-exchange factorBiochemical Journal.  438:447-455. 2011
2011 Structural basis for the function of Tim50 in the mitochondrial presequence translocaseJournal of Molecular Biology.  411:513-519. 2011
2011 ACK2-dependent mechanism for activation of the JAK-STAT signaling pathwayBlood.  118:156-166. 2011
2011 Membrane binding mechanism of yeast mitochondrial peripheral membrane protzein TIM44Protein and Peptide Letters.  18:718-725. 2011
2011 The structure of the PERK kinase domain suggests the mechanism for its activationActa Crystallographica Section D: Biological Crystallography.  67:423-428. 2011
2011 Structural insight into the protective role of P58(IPK) during unfolded protein responseMethods in Enzymology.  490:259-270. 2011
2010 The structural plasticity of Tom71 for mitochondrial precursor translocationsActa Crystallographica Section F: Structural Biology and Crystallization Communications.  66:985-989. 2010
2010 Crystal structure of P58(IPK) TPR fragment reveals the mechanism for its molecular chaperone activity in UPRJournal of Molecular Biology.  397:1307-1315. 2010
2010 Recognition of histone H3K4 trimethylation by the plant homeodomain of PHF2 modulates histone demethylationJournal of Biological Chemistry.  285:9322-9326. 2010
2009 The Crystal Structures of Yeast Get3 Suggest a Mechanism for Tail-Anchored Protein Membrane InsertionPLoS ONE.  4. 2009
2009 Molecular chaperone Hsp70/Hsp90 prepares the mitochondrial outer membrane translocon receptor Tom71 for preprotein loadingJournal of Biological Chemistry.  284:23852-23859. 2009
2009 Preliminary X-ray crystallographic studies of yeast Get3Acta Crystallographica Section F: Structural Biology and Crystallization Communications.  65:489-491. 2009
2009 Heat shock protein 40: Structural studies and their functional implicationsProtein and Peptide Letters.  16:606-612. 2009
2008 Preliminary X-ray crystallographic studies of mouse UPR responsive protein P58(IPK) TPR fragmentActa Crystallographica Section F: Structural Biology and Crystallization Communications.  64:108-110. 2008
2008 The crystal structure of the putative peptide-binding fragment from the human Hsp40 protein Hdj1BMC Structural Biology.  8. 2008
2008 SAD phasing by OASIS at different resolutions down to 0.30 nm and belowWuli Xuebao.  17:1-9. 2008
2006 Crystal structure of yeast Sis1 peptide-binding fragment and Hsp70 Ssa1 C-terminal complexBiochemical Journal.  398:353-360. 2006
2006 Crystal structure of yeast mitochondrial outer membrane translocon member Tom70pNature Structural Biology.  13:589-593. 2006
2006 Preliminary X-ray crystallographic studies of yeast mitochondrial protein Tom70pActa Crystallographica Section F: Structural Biology and Crystallization Communications.  62:265-267. 2006
2006 Crystal Structure of Yeast Mitochondrial Peripheral Membrane Protein Tim44p C-terminal DomainJournal of Molecular Biology.  359:798-804. 2006
2006 Preliminary crystallographic studies of yeast mitochondrial peripheral membrane protein Tim44pActa Crystallographica Section F: Structural Biology and Crystallization Communications.  62:172-174. 2006
2005 Structure-based mutagenesis studies of the peptide substrate binding fragment of type I heat-shock protein 40Biochemical Journal.  386:453-460. 2005
2005 The crystal structure of the C-terminal fragment of yeast Hsp40 Ydj1 reveals novel dimerization motif for Hsp40Journal of Molecular Biology.  346:1005-1011. 2005
2004 Peptide substrate identification for yeast Hsp40 Ydj1 by screening the phage display libraryBiological Procedures Online.  6:204-208. 2004
2003 Preliminary X-ray crystallographic studies of yeast Hsp40 Ydj1 complexed with its peptide substrateActa Crystallographica Section D: Biological Crystallography.  59:1317-1319. 2003
2003 Crystal structure of the E. coli Hsp100 ClpB N-terminal domainStructure.  11:323-328. 2003
2003 The Crystal Structure of the Yeast Hsp40 Ydj1 Complexed with Its Peptide SubstrateStructure.  11:1475-1483. 2003
2002 Crystal structure of the cytoskeleton-associated protein glycine-rich (CAP-Gly) domainJournal of Biological Chemistry.  277:48596-48601. 2002
2002 Cloning, expression, purification and preliminary X-ray crystallographic studies of Escherichia coli Hsp100 nucleotide-binding domain 2 (NBD2)Acta Crystallographica Section D: Biological Crystallography.  58:1030-1031. 2002
2002 Crystal structure of E. coli Hsp100 ClpB nucleotide-binding domain 1 (NBD1) and mechanistic studies on ClpB ATPase activity.Journal of Molecular Biology.  318:1127-1137. 2002
2002 Direct interactions between molecular chaperones heat-shock protein (Hsp) 70 and Hsp40: Yeast Hsp70 Ssa1 binds the extreme C-terminal region of yeast Hsp40 Sis1Biochemical Journal.  361:27-34. 2002
2001 Cloning, expression, purification and preliminary X-ray crystallographic studies of Escherichia coli Hsp100 ClpB N-terminal domainActa Crystallographica Section D: Biological Crystallography.  57:1933-1935. 2001
2001 The crystal structure of the influenza matrix protein M1 at neutral pH: M1-M1 protein: Interfaces can rotate in the oligomeric structures of M1Virology.  289:34-44. 2001
2001 Cloning, expression, purification and preliminary X-ray crystallographic studies of escherichia coli Hsp100 ClpB nucleotide-binding domain 1 (NBD1)Acta Crystallographica Section D: Biological Crystallography.  57:909-911. 2001
2001 Cloning, expression, purification and preliminary X-ray crystallographic studies of yeast Hsp40 Sis1 complexed with Hsp70 Ssa1 C-terminal lid domainActa Crystallographica Section D: Biological Crystallography.  57:748-750. 2001
2000 The crystal structure of the peptide-binding fragment from the yeast Hsp40 protein Sis1Structure.  8:799-807. 2000
1999 PI transfer protein: The specific recognition of phospholipids and its functionsBiochimica et Biophysica Acta Molecular and Cell Biology of Lipids.  1441:268-277. 1999
1999 Purification, crystallization and preliminary X-ray crystallographic studies of S. cerevisiae Hsp40 Sis1Acta Crystallographica Section D: Biological Crystallography.  55:1234-1236. 1999
1999 Structural similarities between influenza virus matrix protein M1 and human immunodeficiency virus matrix and capsid proteins: An evolutionary link between negative-stranded RNA viruses and retrovirusesJournal of General Virology.  80:863-869. 1999
1999 Yeast Sec14p deficient in phosphatidylinositol transfer activity is functional in vivoMolecular Cell.  4:187-197. 1999
1998 Crystal structure of the Saccharomyces cerevisiae phosphatidylinositol- transfer proteinNature.  391:506-510. 1998
1997 Structure of a bifunctional membrane-RNA binding protein, influenza virus matrix protein M1Nature Structural Biology.  4:239-244. 1997
1997 Crystallization and preliminary X-ray crystallographic studies of type A influenza virus matrix protein M1Acta Crystallographica Section D: Biological Crystallography.  53:458-460. 1997
1997 Crystallization and preliminary X-ray diffraction studies of the Saccharomyces cerevisiae phospholipid-transfer protein Sec14pActa Crystallographica Section D: Biological Crystallography.  53:784-786. 1997
1994 EDIM93: a program for electron diffraction intensity measurement from photographic dataJournal of Applied Crystallography.  27:430-432. 1994
1994 Direct methods for incommensurate intergrowth compounds. II. Determination of the modulation using only main reflectionsActa Crystallographica Section a Foundations of Crystallography.  50:511-515. 1994
1993 Correction for the dynamical electron diffraction effect in crystal structure analysisActa Crystallographica Section a Foundations of Crystallography.  49:877-880. 1993
1992 Structural features of the incommensurate modulation in the Pb-doped Bi-2223 high-T c phase revealed by direct-method electron diffraction analysisSuperconductor Science and Technology.  5:69-72. 1992
1992 Incommensurate modulation of the bi-2223 superconducting phase observed by direct-method electron diffraction analysisPhysica Scripta.  1992:18-19. 1992
1991 Prevalence of measles antibodies in asymptomatic human immunodeficiency virus-infected adultsJournal of Infectious Diseases.  164:973-975. 1991

Education And Training

  • Doctor of Philosophy Level Degree in Biochemistry, 1994
  • Full Name

  • Bingdong Sha