Positions

Overview

  • A. Brent Carter received his medical degree at the University of Missouri. His post-graduate training as a resident in internal medicine and as a fellow in pulmonary and critical care medicine was completed at the University of Iowa Carver College of Medicine. Dr. Carter became a faculty member in Internal Medicine at the University of Iowa. He is now a professor in medicine and Scientific Director of the Interstitial Lung Disease Program at UAB.
  • Selected Publications

    Academic Article

    Year Title Altmetric
    2019 Mitochondrial calcium uniporter regulates PGC-1α expression to mediate metabolic reprogramming in pulmonary fibrosis 2019
    2019 NOX4 modulates macrophage phenotype and mitochondrial biogenesis in asbestosis 2019
    2019 Reply to Eapen et al.: Dysfunctional immunity and microbial adhesion molecules in smoking-induced pneumonia 2019
    2018 Macrophage Rac2 is required to reduce the severity of cigarette smoke-induced pneumonia 2018
    2017 Serpine 1 induces alveolar type II cell senescence through activating p53-p21-Rb pathway in fibrotic lung disease 2017
    2017 Macrophages utilize the mitochondrial calcium uniporter for profibrotic polarization 2017
    2017 NADPH Oxidase 4 (Nox4) suppresses mitochondrial biogenesis and bioenergetics in lung fibroblasts via a nuclear factor erythroid-derived 2-like 2 (Nrf2)-dependent pathway 2017
    2016 Assay to evaluate BAL Fluid regulation of Fibroblast α-SMA Expression. 2016
    2016 Determination of H2O2 Generation by pHPA Assay. 2016
    2016 Cu,Zn-superoxide dismutase-mediated redox regulation of Jumonji domain containing 3 modulates macrophage polarization and pulmonary fibrosis 2016
    2016 Macrophage Akt1 Kinase-Mediated Mitophagy Modulates Apoptosis Resistance and Pulmonary Fibrosis 2016
    2016 CaMKII inhibition in type II pneumocytes protects from bleomycin-induced pulmonary fibrosis by preventing Ca2+-dependent apoptosis. 2016
    2015 The Metabolic Prospective and Redox Regulation of Macrophage Polarization. 2015
    2015 Alternative activation of macrophages and pulmonary fibrosis are modulated by scavenger receptor, macrophage receptor with collagenous structure 2015
    2015 Targeting the isoprenoid pathway to abrogate progression of pulmonary fibrosis 2015
    2015 Heme oxygenase-1-mediated autophagy protects against pulmonary endothelial cell death and development of emphysema in cadmium-treated mice 2015
    2015 Mitochondrial-targeted antioxidant therapy decreases transforming growth factor-β-mediated collagen production in a murine asthma model 2015
    2014 Modulation of the mevalonate pathway by AKT regulates macrophage survival and development of pulmonary fibrosis 2014
    2014 3 Asbestos-induced disruption of calcium homeostasis induces endoplasmic reticulum stress in macrophages 2014
    2014 Acrolein-exposed normal human lung fibroblasts in vitro: Cellular senescence, enhanced telomere erosion, and degradation of Werner's syndrome protein 2014
    2013 Accelerated development of pulmonary fibrosis via Cu,Zn-superoxide dismutase-induced alternative activation of macrophages 2013
    2012 Expression of Human Paraoxonase 1 Decreases Superoxide Levels and Alters Bacterial Colonization in the Gut of Drosophila melanogaster 2012
    2012 SP-1 regulation of MMP-9 expression requires Ser586in the PEST domain 2012
    2012 The multifunctional Ca2+/calmodulin-dependent kinase II regulates vascular smooth muscle migration through matrix metalloproteinase 9. 2012
    2012 Mitochondrial Rac1 GTPase import and electron transfer from cytochrome c are required for pulmonary fibrosis 2012
    2011 Mitochondrial Cu,Zn-superoxide dismutase mediates pulmonary fibrosis by augmenting H2O2 generation 2011
    2010 Rac1-mediated mitochondrial H 2 O 2 generation regulates MMP-9 gene expression in macrophages via inhibition of SP-1 and AP-1 2010
    2010 Nuclear factor kappa B-dependent gene transcription in cholecystokinin- and tumor necrosis factor-α-stimulated isolated acinar cells is regulated by p38 mitogen-activated protein kinase 2010
    2009 Modulation of reactive oxygen species by Rac1 or catalase prevents asbestos-induced pulmonary fibrosis 2009
    2008 15-Deoxy-Δ12,14-prostaglandin J2 impairs phosphatidylcholine synthesis and induces nuclear accumulation of thiol-modified cytidylyltransferase 2008
    2008 Asbestos-induced MKP-3 expression augments TNF-α gene expression in human monocytes 2008
    2008 The Nalp3 inflammasome is essential for the development of silicosis 2008
    2008 Regulation of normal cell cycle progression by flavin-containing oxidases 2008
    2008 Enteral exclusion increases map kinase activation and cytokine production in a model of gallstone pancreatitis 2008
    2007 Constitutive NADPH oxidase and increased mitochondrial respiratory chain activity regulate chemokine gene expression 2007
    2007 Differential expression and oxidation of MKP-1 modulates TNF-α gene expression 2007
    2005 Oxysterols inhibit phosphatidylcholine synthesis via ERK docking and phosphorylation of CTP:phosphocholine cytidylyltransferase 2005
    2004 High levels of catalase and glutathione peroxidase activity dampen H 2O2 signaling in human alveolar macrophages 2004
    2003 Respiratory Syncytial Virus Up-regulates TLR4 and Sensitizes Airway Epithelial Cells to Endotoxin 2003
    2002 Phosphatidylinositol 3-kinase activity negatively regulates stability of cyclooxygenase 2 mRNA. 2002
    2002 Oxidant-mediated increases in redox factor-1 nuclear protein and activator protein-1 DNA binding in asbestos-treated macrophages 2002
    2002 Respiratory syncytial virus inhibits apoptosis and induces NF-kappa B activity through a phosphatidylinositol 3-kinase-dependent pathway. 2002
    2001 Ceramide regulates lipopolysaccharide-induced phosphatidylinositol 3-kinase and Akt activity in human alveolar macrophages 2001
    2001 The Absence of Activator Protein 1-dependent Gene Expression in THP-1 Macrophages Stimulated with Phorbol Esters Is Due to Lack of p38 Mitogen-activated Protein Kinase Activation 2001
    2001 Lipopolysaccharide activates Akt in human alveolar macrophages resulting in nuclear accumulation and transcriptional activity of β-catenin 2001
    2001 GM-CSF increases AP-1 DNA binding and Ref-1 amounts in human alveolar macrophages 2001
    2000 Protein kinase C ζ plays a central role in activation of the p42/44 mitogen-activated protein kinase by endotoxin in alveolar macrophages 2000
    2000 A constitutive active MEK → ERK pathway negatively regulates NF-κB-dependent gene expression by modulating TATA-binding protein phosphorylation 2000
    2000 Activation of ERK2 by respiratory syncytial virus in A549 cells is linked to the production of interleukin 8 2000
    1999 The p38 mitogen-activated protein kinase is required for NF-κB- dependent gene expression. The role of TATA-binding protein (TBP) 1999
    1999 Human alveolar macrophages are markedly deficient in REF-1 and AP-1 DNA binding activity 1999
    1999 A phosphatidylcholine-specific phospholipase C regulates activation of p42/44 mitogen-activated protein kinases in lipopolysaccharide-stimulated human alveolar macrophages 1999
    1999 TNF-alpha increases ceramide without inducing apoptosis in alveolar type II epithelial cells. 1999
    1999 TNF-α increases ceramide without inducing apoptosis in alveolar type II epithelial cells 1999
    1999 Both Erk and p38 kinases are necessary for cytokine gene transcription 1999
    1999 Therapy for ventilator-associated pneumonia 1999
    1998 Changes in PKC isoforms in human alveolar macrophages compared with blood monocytes 1998
    1998 Changes in PKC isoforms in human alveolar macrophages compared with blood monocytes. 1998
    1998 Lipopolysaccharide-induced NF-κB activation and cytokine release in human alveolar macrophages is PKC-independent and TK- and PC-PLC-dependent 1998
    1997 Massive pleural effusion in diffuse granulomatous disease 1997

    Research Overview

  • Dr. Carter’s research interests are related to the regulation of inflammatory and fibrotic responses that occur in the lung in models of environmental lung injury and pulmonary fibrosis. Dr. Carter’s studies include investigations dealing with the role of reactive oxygen species and mitochondrial dynamics in the development of inflammatory and fibrotic responses and the regulation of the signal transduction pathways in macrophages that induce the development of pulmonary fibrosis.
  • Education And Training

  • University of Iowa Hospitals and Clinics, Residency 1995
  • University of Iowa Hospitals and Clinics, Postdoctoral Fellowship 1998
  • Full Name

  • Aaron Carter