Positions

Overview

  • Dr. Brott came to UAB in November, 2000 as an Assistant Professor of Medicine in the Division of Cardiovascular Disease. She obtained a Bachelor of Science in Materials Science and Engineering from the Massachusetts Institute of Technology. She then completed her medical degree at Loyola University, Stritch School of Medicine in Maywood, IL in 1988 and completed an Internal Medicine residency (1991) at Beth Israel Medical Center – Harvard Medical School in Boston, MA. Dr. Brott completed both a General Cardiology fellowship (1994) and an Interventional Cardiology fellowship (1995) at Duke University, Durham, NC. Afterwards, she was hired on with Vanderbilt University and stayed there for four years before joining us the Division of Cardiovascular Disease at UAB.

    Dr. Brott is an active member of the Interventional Cardiology section, and serves as the Director of the Interventional Cardiology Fellowship Program.

    Dr. Brott serves on the editorial boards of the Journal of the American College of Cardiology and JACC: Cardiovascular Interventions, and is a reviewer of numerous journals. Dr. Brott serves on several councils and grant review committees including the American Heart Association Council on Clinical Cardiology (2004 – present), NIH BMBI Study Section (Biomaterials and Biointerfaces) (2009 – 2016), NIH SBIB Study Section (Surgical Sciences, Biomedical Imaging, and Bioengineering) (2013 – present), and the NIH Special Emphasis Panel - Biomedical Imaging and Engineering Area Review.
  • Selected Publications

    Academic Article

    Year Title Altmetric
    2018 Myocardial rupture after small acute myocardial infarction in the absence of coronary artery diseaseCardiovascular Pathology.  37:26-29. 2018
    2018 Drug-Eluting Balloon Therapy for In-Stent Restenosis of Drug-Eluting Stents: Choose and Prepare the Appropriate Lesion JACC: Cardiovascular Interventions.  11:979-980. 2018
    2018 Multisite Investigation of Outcomes With Implementation of CYP2C19 Genotype-Guided Antiplatelet Therapy After Percutaneous Coronary InterventionJACC: Cardiovascular Interventions.  11:181-191. 2018
    2018 Nanomatrix Coated Stent Enhances Endothelialization but Reduces Platelet, Smooth Muscle Cell, and Monocyte Adhesion under Physiologic ConditionsACS Biomaterials Science and Engineering.  4:107-115. 2018
    2018 Myocardial tissue characterization by combining late gadolinium enhancement imaging and percent edema mapping: a novel T2 map-based MRI method in canine myocardial infarction.European Radiology Experimental.  2:6. 2018
    2017 Precision Medicine at the University of Alabama at Birmingham: Laying the Foundational Processes Through Implementation of Genotype-Guided Antiplatelet TherapyClinical Pharmacology and Therapeutics.  102:493-501. 2017
    2017 Ticagrelor and Eptifibatide Bolus Versus Ticagrelor and Eptifibatide Bolus With 2-Hour Infusion in High-Risk Acute Coronary Syndromes Patients Undergoing Early Percutaneous Coronary InterventionJournal of the American Heart Association : Cardiovascular and Cerebrovascular Disease.  6. 2017
    2017 Mortality following cardiovascular and bleeding events occurring beyond 1 year after coronary stenting: A secondary analysis of the Dual Antiplatelet Therapy (DAPT) StudyJAMA Cardiology.  2:478-487. 2017
    2017 The MRI characteristics of the no-flow region are similar in reperfused and non-reperfused myocardial infarcts: an MRI and histopathology study in swine.European Radiology Experimental.  1:2. 2017
    2016 Safety of hydrophilic guidewires used for side-branch protection during stenting and proximal optimization technique in coronary bifurcation lesionsCardiovascular Revascularization Medicine.  17:456-462. 2016
    2016 The Return of Coronary Vasomotion after Bioresorbable Scaffold ImplantationJACC: Cardiovascular Interventions.  9:742-744. 2016
    2016 Age-independent myocardial infarct quantification by signal intensity percent infarct mapping in swineJournal of Magnetic Resonance Imaging.  43:911-920. 2016
    2016 Novel Multifunctional Nanomatrix Reduces Inflammation in Dynamic Conditions in Vitro and Dilates Arteries ex VivoACS Applied Materials and Interfaces.  8:5178-5187. 2016
    2016 In vivo monitoring of the inflammatory response in a stented mouse aorta modelJournal of Biomedical Materials Research Part A.  104:227-238. 2016
    2016 Metallic stents: Biomechanical analysis and in vivo investigation of the vessel inflammatory responseIfmbe Proceedings.  57:1075-1078. 2016
    2015 A bigger artery is not better predicting coronary plaque ruptureJACC: Cardiovascular Imaging.  8:1188-1190. 2015
    2015 Obesity and percutaneous coronary intervention outcomes: Beware the extremesCatheterization and Cardiovascular Interventions.  85:959-960. 2015
    2015 Percutaneous coronary intervention: Ever closer to real world silver bullets!?Catheterization and Cardiovascular Interventions.  85:807-808. 2015
    2015 Prevention of myocardial stunning during percutaneous coronary interventions: Novel insights from pre-treatment with glucagon-like peptide-1JACC: Cardiovascular Interventions.  8:302-304. 2015
    2015 Can femoral access bleeding outcomes be improved?Catheterization and Cardiovascular Interventions.  85:380-381. 2015
    2015 Evaluation of ciprofloxacin and metronidazole encapsulated biomimetic nanomatrix gel on Enterococcus faecalis and Treponema denticolaBiomaterials Research.  19. 2015
    2015 Optimal DAPT duration: Each in their own timeCatheterization and Cardiovascular Interventions.  85:41-42. 2015
    2015 Transdiaphragmatic rupture of hepatic abscess producing purulent pericarditis and pericardial tamponadeCirculation.  131:e1-e2. 2015
    2014 Multi-scale mechanical investigation of stainless steel and cobalt-chromium stentsJournal of the Mechanical Behavior of Biomedical Materials.  40:240-251. 2014
    2014 ACP Journal Club: review: statins before coronary catheterization reduce contrast-induced acute kidney injury.Annals of Internal Medicine.  161:JC7. 2014
    2014 Left anterior descending coronary artery occlusion secondary to metastatic squamous cell carcinoma presenting as st-segment-elevation myocardial infarctionCirculation.  129. 2014
    2014 Evaluation of the effect of expansion and shear stress on a self-assembled endothelium mimicking nanomatrix coating for drug eluting stents in vitro and in vivoBiofabrication.  6. 2014
    2014 Impact of head rotation on the individualized common carotid flow and carotid bifurcation hemodynamicsIEEE Journal of Biomedical and Health Informatics.  18:783-789. 2014
    2014 Infarct density distribution by MRI in the porcine model of acute and chronic myocardial infarction as a potential method transferable to the clinicInternational Journal of Cardiac Imaging.  30:937-948. 2014
    2014 Review: Statins before coronary catheterization reduce contrastinduced acute kidney injuryAnnals of Internal Medicine.  161:JC7. 2014
    2013 Thromboaspiration and IIb/IIIa therapy in STEMI: Abciximab redux?Catheterization and Cardiovascular Interventions.  82:612-613. 2013
    2013 CommentaryAnnals of Internal Medicine.  158. 2013
    2013 Enhanced human endothelial progenitor cell adhesion and differentiation by a bioinspired multifunctional nanomatrixTissue Engineering Part C Methods.  19:375-385. 2013
    2013 Histologic analysis of a covered stent implanted for pseudoaneurysm in a coronary arteryCardiovascular Pathology.  22. 2013
    2013 Stent overlapping and geometric curvature influence the structural integrity and surface characteristics of coronary nitinol stentsJournal of the Mechanical Behavior of Biomedical Materials.  20:227-236. 2013
    2013 Effect of head posture on the healthy human carotid bifurcation hemodynamicsMedical and Biological Engineering and Computing.  51:207-218. 2013
    2013 The Safety and Outcomes of Chronic Total Occlusion InterventionsJACC: Cardiovascular Interventions2013
    2012 Saphenous vein grafts: Two substrates, two treatments?Catheterization and Cardiovascular Interventions.  80:1137. 2012
    2012 Stent overlapping and geometric curvature influence the structural integrity and surface characteristics of coronary stentsASME 2012 Summer Bioengineering Conference, SBC 2012.  559-560. 2012
    2012 ACP Journal Club: 24- and 6-month dual antiplatelet therapy after coronary stenting did not differ for clinical outcomes.Annals of Internal Medicine.  157:JC2-JC9. 2012
    2012 CommentaryAnnals of Internal Medicine.  157. 2012
    2012 Embozene™ microspheres induced nonreperfused myocardial infarction in an experimental swine modelCatheterization and Cardiovascular Interventions.  45. 2012
    2012 Determination of infarct size in Ex Vivo swine hearts by multidetector computed tomography using gadolinium as contrast mediumInvestigative Radiology.  47:277-283. 2012
    2012 Acute infarct selective MRI contrast agentInternational Journal of Cardiac Imaging.  28:285-293. 2012
    2012 The role of vascular calcification in inducing fatigue and fracture of coronary stentsJournal of Biomedical Materials Research.  100 B:292-304. 2012
    2011 Biocorrosion and biomechanical analysis of vascular stentsASME 2011 Summer Bioengineering Conference, SBC 2011.  769-770. 2011
    2011 Quantification of myocardial viability distribution with Gd(DTPA) bolus-enhanced, signal intensity-based percent infarct mappingMagnetic Resonance Imaging.  29:650-658. 2011
    2011 Microarray applications in occlusive vascular diseaseCardiovascular and Hematological Agents in Medicinal Chemistry.  9:84-94. 2011
    2011 Vasomotor function after paclitaxel-coated balloon post-dilation in porcine coronary stent modelJACC: Cardiovascular Interventions.  4:247-255. 2011
    2011 A hybrid biomimetic nanomatrix composed of electrospun polycaprolactone and bioactive peptide amphiphiles for cardiovascular implantsActa Biomaterialia.  7:225-233. 2011
    2011 Effect of posture change on the geometric features of the healthy carotid bifurcationIEEE Transactions on Information Technology in Biomedicine.  15:148-154. 2011
    2011 Linking drug-eluting stent kinetics and clinical outcomes: Insights from optical coherence tomographyJACC: Cardiovascular Interventions.  4:786-788. 2011
    2011 Oral antiplatelet therapy in diabetes mellitus and the role of prasugrel: An overviewVascular Health and Risk Management.  7:445-459. 2011
    2010 In-vivo corrosion and local release of metallic ions from vascular stents into surrounding tissueJournal of Invasive Cardiology.  22:528-535. 2010
    2010 Clinical device-related article surface characterization of explanted endovascular stents: Evidence of in vivo corrosionJournal of Biomedical Materials Research.  95:225-238. 2010
    2010 Differentiation of acute and four-week old myocardial infarct with Gd(ABE-DTTA)-enhanced CMRJournal of Cardiovascular Magnetic Resonance.  12. 2010
    2010 Stainless steel ions stimulate increased thrombospondin-1-dependent tgf-beta activation by vascular smooth muscle cells: Implications for in-stent restenosisJournal of Vascular Research.  47:309-322. 2010
    2010 A nitric oxide releasing, self assembled peptide amphiphile matrix that mimics native endothelium for coating implantable cardiovascular devicesBiomaterials.  31:1502-1508. 2010
    2010 Human postmortem device retrieval and analysis - Orthopaedic, cardiovascular, and dental systemsJournal of Long-Term Effects of Medical Implants.  20:81-85. 2010
    2010 Percent infarct mapping for delayed contrast enhancement magnetic resonance imaging to quantify myocardial viability by Gd(DTPA).Journal of Magnetic Resonance Imaging.  32:859-868. 2010
    2009 Late Vascular Healing Response to Stents. New Insights From Optical Coherence TomographyJournal of the American College of Cardiology.  55:33-34. 2009
    2009 Corrosion of metallic endovascular stents and analyses of wear debris in tissuesProceedings of the ASME Summer Bioengineering Conference 2009, SBC2009.  1125-1126. 2009
    2009 Local release of metallic ions from stents into vascular tissue and associated alterations of stent surfacesProceedings of the ASME Summer Bioengineering Conference, SBC2008.  759-760. 2009
    2009 ACP Journal Club. Prasugrel prevented ischemic events compared with clopidogrel in patients having PCI for STEMI.Annals of Internal Medicine.  150:JC6-J10. 2009
    2009 Prasugrel prevented ischemic events compared with clopidogrel in patients having PCI for STEMI: CommentaryAnnals of Internal Medicine.  150. 2009
    2009 Pretreatment with nitroprusside for microcirculatory protection in saphenous vein graft interventionsJournal of Invasive Cardiology.  21:34-39. 2009
    2009 Myocardial strain in sub-acute peri-infarct myocardiumInternational Journal of Cardiac Imaging.  25:151-159. 2009
    2008 Head-to-head comparison between delayed enhancement and percent infarct mapping for assessment of myocardial infarct size in a canine modelJournal of Magnetic Resonance Imaging.  28:1386-1392. 2008
    2008 Hemodynamic analysis of a compliant femoral artery bifurcation model using a fluid structure interaction frameworkAnnals of Biomedical Engineering.  36:1753-1763. 2008
    2008 Vascular changes and black hole phenomenon after coronary brachytherapy: A pathologically distinct entityJournal of Invasive Cardiology.  20:560-562. 2008
    2008 Assessment of passive cardiovascular implant devices for MRI compatibilityTechnology and Health Care.  16:233-245. 2008
    2008 Prasugrel reduced ischemic outcomes more than did clopidogrel in patients receiving stents for ACS.Acp Journal Club.  149:12. 2008
    2008 Review: late percutaneous coronary intervention after AMI improves survival more than optimal medical therapy.Acp Journal Club.  149:6. 2008
    2008 Automated multidetector computed tomography evaluation of subacutely infarcted myocardiumJournal of Cardiovascular Computed Tomography.  2:26-32. 2008
    2007 In vivo myocardial tissue kinetics of Gd(ABE-DTTA), a tissue-persistent contrast agentMagnetic Resonance in Medicine.  58:55-64. 2007
    2007 Effects of venous needle turbulence during ex vivo hemodialysis on endothelial morphology and nitric oxide formationJournal of Biomechanics.  40:2158-2166. 2007
    2007 Equilibrium signal intensity mapping, an MRI method for fast mapping of longitudinal relaxation rates and for image enhancementMagnetic Resonance Imaging.  25:641-651. 2007
    2007 Urgent revascularization with PCI was more cost-effective than CABG in medically refractory, high-risk myocardial ischemia.Acp Journal Club.  146:49. 2007
    2006 Severe, diffuse coronary artery spasm after drug-eluting stent placementJournal of Invasive Cardiology.  18:584-592. 2006
    2006 Percent infarct mapping: An R1-map-based CE-MRI method for determining myocardial viability distributionMagnetic Resonance in Medicine.  56:535-545. 2006
    2006 Gd(ABE-DTTA), a novel contrast agent, at the MRI-effective dose shows absence of deleterious physiological effects in dogsPharmacology.  77:188-194. 2006
    2005 Turbulent flow evaluation of the venous needle during hemodialysisJournal of Biomechanical Engineering.  127:1141-1146. 2005
    2005 Evaluation of in-stent stenosis by magnetic resonance phase-velocity mapping in nickel-titanium stentsJournal of Magnetic Resonance Imaging.  22:248-257. 2005
    2005 Invasive strategy within 24 hours of thrombolysis reduced death, nonfatal reinfarction, and ischemia-induced revascularization in STEMI.Acp Journal Club.  142:38. 2005
    2005 Magnetic resonance phase velocity mapping through NiTi stents in a flow phantom modelJournal of Magnetic Resonance Imaging.  21:59-65. 2005
    2004 Long-Term Follow-Up of Brachytherapy for Treatment of Allograft In-Stent RestenosisCatheterization and Cardiovascular Interventions.  61:217-221. 2004
    2003 Review: low-molecular-weight heparin is effective and safe in the acute coronary syndromes.Acp Journal Club.  139:58. 2003
    2003 Treatment of In-Stent Restenosis in a Gastroepiploic Artery Coronary Bypass Graft with BrachytherapyJournal of Invasive Cardiology.  15:677-680. 2003
    2003 An early invasive strategy reduced death, myocardial infarction, and hospital readmissions at 2 years in unstable CAD.Acp Journal Club.  139:30. 2003
    2003 Long-term mortality and cardiovascular morbidity increased in some patients with asymptomatic mitral valve prolapse.Acp Journal Club.  138:76. 2003
    2003 An interventional strategy was better than a conservative strategy in unstable angina or non-ST-elevation MI.Acp Journal Club.  138:32. 2003
    2002 Relationship between activated clotting time during percutaneous intervention and subsequent bleeding complicationsAmerican Heart Journal.  144:501-507. 2002
    1998 Stent procedure complicated by thrombus formation distal to the lesion within a muscle bridgeCatheterization and cardiovascular diagnosis.  43:73-76. 1998
    1995 Intravascular ultrasound in the management of acute coronary artery dissection: A case reportCatheterization and cardiovascular diagnosis.  34:251-254. 1995
    1985 Bioerodible polyanhydrides as drug‐carrier matrices. I: Characterization, degradation, and release characteristicsJournal of Biomedical Materials Research.  19:941-955. 1985

    Research Overview

  • Dr. Brigitta Brott’s research interests are the understanding of endovascular device – artery interactions and the improvement of vascular compatibility of stents and other implants. She also focuses on the treatment of patients with congestive heart failure using local delivery of novel cell therapies. Her focus is on the development and evaluation of new interventional device coatings, in order to improve patient outcomes. In this role, she has co-founded Endomimetics, LLC, a UAB spin-off company, which develops coatings to improve healing and inhibit abnormal clotting on implants.
  • Principal Investigator On

  • Private Grant  awarded by ABIOMED, INC. 2016 - 2021
  • Private Grant  awarded by ABIOMED, INC. 2012 - 2020
  • Abbott Fund Interventional Fellowship Grant 2018-2019  awarded by Abbott Laboratories Fund 2018 - 2019
  • Abbott Fund Interventional Fellowship Grant 2017-2018  awarded by Rockefeller Philanthropy Advisors 2017 - 2018
  • Private Grant  awarded by CARDIUM THERAPEUTICS 2008 - 2018
  • Abbott Interventional Fellowship Grant 2016-2017  awarded by Abbott Laboratories Fund 2016 - 2017
  • Abbott Interventional Fellowship Grant 2015-2016  awarded by Abbott Laboratories Fund 2015 - 2016
  • Private Grant  awarded by CORDIS CORPORATION 2004 - 2015
  • Abbott Interventional Fellowship Grant 2014-2015  awarded by Abbott Laboratories Fund 2014 - 2015
  • Private Grant  awarded by DATASCOPE, INC. 2011 - 2015
  • Private Grant  awarded by Gilead Sciences 2013 - 2015
  • Private Grant  awarded by ELI LILLY AND COMPANY 2010 - 2015
  • Private Grant  awarded by MAQUET CARDIOVASCULAR, LLC 2014 - 2015
  • Private Grant  awarded by CORDIS CORPORATION 2011 - 2014
  • Abbott Interventional Fellowship Grant 2013-2014  awarded by Abbott Laboratories Fund 2013 - 2014
  • Private Grant  awarded by ABBOTT VASCULAR, INC. 2012 - 2014
  • Private Grant  awarded by CARDIOVASCULAR BIOTHERAPEUTICS 2009 - 2014
  • Private Grant  awarded by Baxter Healthcare Corporation 2012 - 2014
  • Abbott Interventional Fellowship 2012/2013  awarded by Abbott Laboratories Fund 2012 - 2013
  • SCAI Interventional Fellowship 2012/2013  awarded by Society for Cardiovascular Angiography and Interventions 2012 - 2013
  • Private Grant  awarded by BRISTOL MYERS SQUIBB PHARMACEUTICAL COMPANY 2009 - 2013
  • Private Grant  awarded by AGA MEDICAL CORPORATION 2011 - 2013
  • Private Grant  awarded by MERCK & COMPANY, INC. 2011 - 2012
  • Private Grant  awarded by TAKEDA GLOBAL RESEARCH & DEVELOPMENT CENTER 2009 - 2012
  • Interventional Cardiology SCAI 2011/2012  awarded by Society for Cardiovascular Angiography and Interventions 2012
  • Private Grant  awarded by ABBOTT BIOTHERAPEUTICS 2011 - 2012
  • Private Grant  awarded by CONOR MEDSYSTEMS, INC. 2005 - 2011
  • Investigator On

  • Private Grant  awarded by TEVA BRANDED PHARMACEUTICAL PRODUCTS R&D 2015 - 2023
  • Private Grant  awarded by ABBOTT VASCULAR, INC. 2013 - 2023
  • Private Grant  awarded by CARDIOVASCULAR SYSTEM INC. 2019 - 2023
  • Private Grant  awarded by St. Jude Medical 2015 - 2022
  • Private Grant  awarded by BOSTON SCIENTIFIC CORPORATION 2018 - 2022
  • Private Grant  awarded by ACIST MEDICAL SYSTEMS, INC 2018 - 2022
  • Private Grant  awarded by CELLAEGIS US INC 2018 - 2022
  • Private Grant  awarded by St. Jude Medical 2019 - 2022
  • Patient Oriented Research in Personalized Antithrombotic Therapy  awarded by National Heart, Lung, and Blood Institute/NIH/DHHS 2016 - 2021
  • Private Grant  awarded by BRISTOL MYERS SQUIBB PHARMACEUTICAL COMPANY 2016 - 2021
  • Prohealing Multifunctional Endothelium Nanomatrix Coated Stent  awarded by National Heart, Lung, and Blood Institute/NIH/DHHS 2015 - 2019
  • Private Grant  awarded by PLC MEDICAL SYSTEMS, INC. 2016 - 2019
  • Private Grant  awarded by AASTROM BIOSCIENCES, INC. 2013 - 2018
  • Private Grant  awarded by DAIICHI SANKYO, INC. 2017 - 2018
  • Private Grant  awarded by ASTRAZENECA PHARMACEUTICALS LP 2013 - 2017
  • Pharmacogenomic Resource for Improving Medication Effectiveness (PRIME)  awarded by UNIVERSITY OF ALABAMA HEALTH SERVICES FOUNDATION 2013 - 2017
  • Private Grant  awarded by AMORCYTE, INC. 2012 - 2016
  • Private Grant  awarded by St. Jude Medical 2015
  • Private Grant  awarded by ABBOTT VASCULAR, INC. 2014 - 2015
  • Private Grant  awarded by St. Jude Medical 2013 - 2015
  • Private Grant  awarded by ABBOTT VASCULAR, INC. 2009 - 2014
  • Implanted Coronary Artery Stents Crack and Corrode: A Structural Integrity and Tissue Inflammation Analysis  awarded by CYPRUS RESEARCH PROMOTION FOUNDATION 2010 - 2014
  • Private Grant  awarded by ASTRAZENECA PHARMACEUTICALS LP 2014
  • Private Grant  awarded by ACCUMETRICS, INC. 2008 - 2013
  • Private Grant  awarded by SCHERING PLOUGH CORPORATION 2007 - 2012
  • Private Grant  awarded by ABIOMED, INC. 2009 - 2012
  • Private Grant  awarded by CARDIODX, INC 2010 - 2012
  • Education And Training

  • Doctor of Medicine, Loyola University Chicago 1988
  • Beth Israel Hospital, Residency 1991
  • Duke University Medical Center, Postdoctoral Fellowship 1995
  • Full Name

  • Brigitta Brott