Positions

Selected Publications

Academic Article

Year Title Altmetric
2018 Mycobacterium tuberculosis induces decelerated bioenergetic metabolism in human macrophages.eLife.  7. 2018
2018 Microanatomic Distribution of Myeloid Heme Oxygenase-1 Protects against Free Radical-Mediated Immunopathology in Human Tuberculosis.Cell Reports.  25:1938-1952.e5. 2018
2018 Arylvinylpiperazine Amides, a New Class of Potent Inhibitors Targeting QcrB of Mycobacterium tuberculosis.mBio.  9. 2018
2018 Host-pathogen redox dynamics modulate Mycobacterium tuberculosis pathogenesis.Pathogens and Disease.  76. 2018
2018 2-Mercapto-Quinazolinones as Inhibitors of Type II NADH Dehydrogenase and Mycobacterium tuberculosis: Structure-Activity Relationships, Mechanism of Action and Absorption, Distribution, Metabolism, and Excretion Characterization.ACS Infectious Diseases.  4:954-969. 2018
2018 RbpA and σB association regulates polyphosphate levels to modulate mycobacterial isoniazid-tolerance.Microbiological sciences.  108:627-640. 2018
2018 Ferritin H Deficiency in Myeloid Compartments Dysregulates Host Energy Metabolism and Increases Susceptibility to Mycobacterium tuberculosis Infection.Frontiers in Immunology.  9:860. 2018
2017 Role of Ergothioneine in Microbial Physiology and Pathogenesis.Antioxidants and Redox Signaling.  28:431-444. 2017
2017 Susceptibility of Mycobacterium tuberculosis Cytochrome bd Oxidase Mutants to Compounds Targeting the Terminal Respiratory Oxidase, Cytochrome c.Antimicrobial Agents and Chemotherapy.  61. 2017
2017 Correction: Mycobacterium tuberculosis arrests host cycle at the G1/S transition to establish long term infection.PLoS Pathogens.  13:e1006490. 2017
2017 Mycobacterium tuberculosis arrests host cycle at the G1/S transition to establish long term infection.PLoS Pathogens.  13:e1006389. 2017
2016 The role of Cryptococcus laurentii and mycorrhizal fungi in the nutritional physiology of Lupinus angustifolius L. hosting N2-fixing nodulesPlant and Soil.  409:345-360. 2016
2016 Attenuated heme oxygenase-1 responses predispose the elderly to pulmonary nontuberculous mycobacterial infections.AJP - Lung Cellular and Molecular Physiology.  311:L928-L940. 2016
2016 Mycobacterial WhiB6 Differentially Regulates ESX-1 and the Dos Regulon to Modulate Granuloma Formation and Virulence in Zebrafish.Cell Reports.  16:2512-2524. 2016
2016 The emerging role of gasotransmitters in the pathogenesis of tuberculosis.Nitric Oxide: Biology and Chemistry.  59:28-41. 2016
2016 Host-directed therapies for infectious diseases: current status, recent progress, and future prospects.Lancet Infectious Diseases.  16:e47-e63. 2016
2016 Yeasts Associated with Culex pipiens and Culex theileri Mosquito Larvae and the Effect of Selected Yeast Strains on the Ontogeny of Culex pipiens.Microbial Ecology.  71:747-760. 2016
2016 Ergothioneine Maintains Redox and Bioenergetic Homeostasis Essential for Drug Susceptibility and Virulence of Mycobacterium tuberculosis.Cell Reports.  14:572-585. 2016
2016 Turning the respiratory flexibility of Mycobacterium tuberculosis against itself.Nature Communications.  7:12393. 2016
2015 Host-Directed Therapies for Tackling Multi-Drug Resistant Tuberculosis: Learning From the Pasteur-Bechamp Debates.Clinical Infectious Diseases.  61:1432-1438. 2015
2015 Metabolic plasticity of central carbon metabolism protects mycobacteria.Proceedings of the National Academy of Sciences.  112:13135-13136. 2015
2015 Regulation of Ergothioneine Biosynthesis and Its Effect on Mycobacterium tuberculosis Growth and Infectivity.Journal of Biological Chemistry.  290:23064-23076. 2015
2015 Towards host-directed therapies for tuberculosis.Nature Reviews Drug Discovery.  14:511-512. 2015
2014 Exposure to cigarette smoke impacts myeloid-derived regulatory cell function and exacerbates airway hyper-responsiveness.Laboratory Investigation.  94:1312-1325. 2014
2014 The Physiology and Genetics of Oxidative Stress in Mycobacteria.Microbiology Spectrum.  2. 2014
2013 S100A8/A9 proteins mediate neutrophilic inflammation and lung pathology during tuberculosis.American Journal of Respiratory and Critical Care Medicine.  188:1137-1146. 2013
2012 Environmental heme-based sensor proteins: implications for understanding bacterial pathogenesis.Antioxidants and Redox Signaling.  17:1232-1245. 2012
2012 Heme oxygenase-1 promotes granuloma development and protects against dissemination of mycobacteria.Laboratory Investigation.  92:1541-1552. 2012
2012 Mycobacterium tuberculosis WhiB4 regulates oxidative stress response to modulate survival and dissemination in vivo.Microbiological sciences.  85:1148-1165. 2012
2012 Iron sulfur cluster proteins and microbial regulation: implications for understanding tuberculosis.Current Opinion in Chemical Biology.  16:45-53. 2012
2012 Mycobacterium tuberculosis WhiB3: a novel iron-sulfur cluster protein that regulates redox homeostasis and virulence.Antioxidants and Redox Signaling.  16:687-697. 2012
2011 Redox homeostasis in mycobacteria: the key to tuberculosis control?Expert Reviews in Molecular Medicine.  13:e39. 2011
2011 A screen to identify small molecule inhibitors of protein-protein interactions in mycobacteria.ASSAY and Drug Development Technologies.  9:299-310. 2011
2010 Conservation of structure and protein-protein interactions mediated by the secreted mycobacterial proteins EsxA, EsxB, and EspA.Journal of Bacteriology.  192:326-335. 2010
2010 Reductive stress in microbes: implications for understanding Mycobacterium tuberculosis disease and persistence.Advances in Microbial Physiology.  57:43-117. 2010
2009 Unexpected effects of starfish grazing on sandflat communities following an outbreakMarine Ecology Progress Series.  398:173-182. 2009
2009 Complex effects of the gastropod Assiminea globulus on benthic community structure in a marine-dominated lagoonJournal of Experimental Marine Biology and Ecology.  380:47-52. 2009
2009 Mycobacterium tuberculosis WhiB3 maintains redox homeostasis by regulating virulence lipid anabolism to modulate macrophage response.PLoS Pathogens.  5:e1000545. 2009
2008 Heme oxygenase-1-derived carbon monoxide induces the Mycobacterium tuberculosis dormancy regulon.Journal of Biological Chemistry.  283:18032-18039. 2008
2007 A partner for the resuscitation-promoting factors of Mycobacterium tuberculosis.Microbiological sciences.  66:658-668. 2007
2007 Mycobacterium tuberculosis DosS is a redox sensor and DosT is a hypoxia sensor.Proceedings of the National Academy of Sciences.  104:11568-11573. 2007
2007 Mycobacterium tuberculosis WhiB3 responds to O2 and nitric oxide via its [4Fe-4S] cluster and is essential for nutrient starvation survival.Proceedings of the National Academy of Sciences.  104:11562-11567. 2007
2006 Dissecting virulence pathways of Mycobacterium tuberculosis through protein-protein association.Proceedings of the National Academy of Sciences.  103:11346-11351. 2006
2005 Evaluation of electrodialysis for the treatment of an industrial solid waste leachateDesalination.  186:273-289. 2005
2003 Nitrate removal with reverse osmosis in a rural area in South AfricaDesalination.  155:15-26. 2003
2003 Interaction of the sensor module of Mycobacterium tuberculosis H37Rv KdpD with members of the Lpr family.Microbiological sciences.  47:1075-1089. 2003
2003 Cloning and characterization of a second alpha-amylase gene (LKA2) from Lipomyces kononenkoae IGC4052B and its expression in Saccharomyces cerevisiae.Yeast.  20:69-78. 2003
2002 Mycobacterium tuberculosis WhiB3 interacts with RpoV to affect host survival but is dispensable for in vivo growth.Proceedings of the National Academy of Sciences.  99:3147-3152. 2002
2001 Investigation into alternative water treatment technologies for the treatment of underground mine water discharged by Grootvlei Proprietary Mines Ltd into the Blesbokspruit in South AfricaDesalination.  133:13-30. 2001
2000 Characterization of the Mycobacterium tuberculosis iniBAC promoter, a promoter that responds to cell wall biosynthesis inhibition.Journal of Bacteriology.  182:1802-1811. 2000
1999 Recent developments in mycobacterial research.Current Opinion in Infectious Diseases.  12:415-424. 1999
1996 Cloning, mapping and characterization of a genomic copy of the Lipomyces kononenkoae alpha-amylase-encoding gene (LKA1).Yeast.  12:925-937. 1996
1996 Cloning, mapping and characterization of a genomic copy of the Lipomyces kononenkoae α-amylase-encoding gene (LKA1)Yeast.  12:925-937. 1996
1996 Treatment using reverse osmosis of an effluent from stainless steel manufactureWater Research.  30:1979-1984. 1996
1995 Cloning, sequence analysis and expression in yeasts of a cDNA containing a Lipomyces kononenkoae alpha-amylase-encoding gene.Gene.  166:65-71. 1995
1995 Characterization of a novel alpha-amylase from Lipomyces kononenkoae and expression of its gene (LKA1) in Saccharomyces cerevisiae.Current Genetics.  28:526-533. 1995
1995 Expression of human P450c17 as an export protein in Saccharomyces cerevisiae.Endocrine Research.  21:289-295. 1995
1993 Regional sequence homologies in starch-degrading enzymes.Current Genetics.  24:400-407. 1993
1993 Expression and secretion of Bacillus amyloliquefaciens alpha-amylase by using the yeast pheromone alpha-factor promoter and leader sequence in Saccharomyces cerevisiae.Applied and Environmental Microbiology.  59:1253-1258. 1993
1991 Co-expression of a Saccharomyces diastaticus glucoamylase-encoding gene and a Bacillus amyloliquefaciens alpha-amylase-encoding gene in Saccharomyces cerevisiae.Gene.  100:85-93. 1991

Chapter

Year Title Altmetric
2013 Protein-protein interaction in the-omics era: Understanding Mycobacterium tuberculosis function.  79-106. 2013

Research Overview

  • Tuberculosis
  • Principal Investigator On

  • Interplay Between the Mtb Electron Transport Chain and Carbon Metabolism  awarded by National Institute of Allergy and Infectious Diseases/NIH/DHHS 2018 - 2023
  • Hydrogen Sulfide and Tuberculosis Disease  awarded by National Institute of Allergy and Infectious Diseases/NIH/DHHS 2018 - 2022
  • Metabolic Reprogramming of T Cell Energy Metabolism in Tuberculosis and HIV  awarded by National Institute of Allergy and Infectious Diseases/NIH/DHHS 2018 - 2020
  • Heme Oxygenase–1 and the Bioenergetic Threshold of Latent TB and HIV Co-Infection  awarded by National Institute of Allergy and Infectious Diseases/NIH/DHHS 2015 - 2020
  • UAB - AHRI agreement for assignment of Dr Adries Steyn as a Scientist in Residence  awarded by AFRICA HEALTH RESEARCH INSTITUTE 2017 - 2019
  • HSF/GEF Scholar Award for Andries Steyn  awarded by UNIVERSITY OF ALABAMA HEALTH SERVICES FOUNDATION 2017 - 2018
  • Immunometabolism of M. Tuberculosis/HIV co-infection  awarded by National Institute of Allergy and Infectious Diseases/NIH/DHHS 2016 - 2018
  • Carbon Monoxide and Mycobacterium Tuberculosis Persistance  awarded by Burroughs Wellcome Fund 2008 - 2016
  • Role of WhiB3 in M. tuberculosis Virulence  awarded by National Institute of Allergy and Infectious Diseases/NIH/DHHS 2010 - 2016
  • Real Time Measurement of Host Bioenergetics During Mycobacterium Tuberculosis Infection  awarded by DOD - ARMY MEDICAL RESEARCH ACQUISITION ACTIVITY 2013 - 2015
  • Cigarette Smoke and Drug Resistant Tuberculosis  awarded by American Lung Association 2012 - 2014
  • Mechanism of Mycobacterium Tuberculosis Persistence  awarded by National Institute of Allergy and Infectious Diseases/NIH/DHHS 2009 - 2014
  • Fostering International Collaboration between US-Based Institutions and K-RITH at the University of Kwazulu-Natal in Durban, South Africa  awarded by Hughes (Howard) Medical Institute 2010 - 2011
  • Education And Training

  • Doctor of Philosophy in Microbiology, Stellenbosch University
  • Full Name

  • Andries Steyn