Positions

Selected Publications

Academic Article

Year Title Altmetric
2019 Group 3 innate lymphoid cells mediate early protective immunity against tuberculosisNature.  570:528-532. 2019
2019 Remembering the host in tuberculosis drug developmentJournal of Infectious Diseases.  219:1518-1524. 2019
2018 Microanatomic Distribution of Myeloid Heme Oxygenase-1 Protects against Free Radical-Mediated Immunopathology in Human TuberculosisCell Reports.  25:1938-1952.e5. 2018
2018 Mycobacterium tuberculosis induces decelerated bioenergetic metabolism in human macrophageseLife.  7. 2018
2018 Arylvinylpiperazine amides, a new class of potent inhibitors targeting QcrB of mycobacterium tuberculosismBio.  9. 2018
2018 Host-pathogen redox dynamics modulate Mycobacterium tuberculosis pathogenesisPathogens and Disease.  76. 2018
2018 2-Mercapto-Quinazolinones as Inhibitors of Type II NADH Dehydrogenase and Mycobacterium tuberculosis: Structure-Activity Relationships, Mechanism of Action and Absorption, Distribution, Metabolism, and Excretion CharacterizationACS Infectious Diseases.  4:954-969. 2018
2018 RbpA and σ B association regulates polyphosphate levels to modulate mycobacterial isoniazid-toleranceMicrobiological sciences.  108:627-640. 2018
2018 Ferritin H deficiency in myeloid compartments dysregulates host energy metabolism and increases susceptibility to Mycobacterium tuberculosis infectionFrontiers in Immunology.  9. 2018
2018 Role of Ergothioneine in Microbial Physiology and PathogenesisAntioxidants and Redox Signaling.  28:431-444. 2018
2017 Erratum: Correction: Mycobacterium tuberculosis arrests host cycle at the G1/S transition to establish long term infection (PLoS pathogens (2017) 13 5 (e1006389))PLoS Pathogens.  13:e1006490. 2017
2017 Mycobacterium tuberculosis arrests host cycle at the G 1 /S transition to establish long term infectionPLoS Pathogens.  13. 2017
2017 Susceptibility of Mycobacterium tuberculosis cytochrome bd oxidase mutants to compounds targeting the terminal respiratory oxidase, cytochrome cAntimicrobial Agents and Chemotherapy.  61. 2017
2016 The role of Cryptococcus laurentii and mycorrhizal fungi in the nutritional physiology of Lupinus angustifolius L. hosting N2-fixing nodulesPlant and Soil.  409:345-360. 2016
2016 The emerging role of gasotransmitters in the pathogenesis of tuberculosisNitric Oxide: Biology and Chemistry.  59:28-41. 2016
2016 Mycobacterial WhiB6 Differentially Regulates ESX-1 and the Dos Regulon to Modulate Granuloma Formation and Virulence in ZebrafishCell Reports.  16:2512-2524. 2016
2016 Turning the respiratory flexibility of Mycobacterium tuberculosis against itselfNature Communications.  7. 2016
2016 Host-directed therapies for infectious diseases: current status, recent progress, and future prospects.Lancet Infectious Diseases.  16:e47-e63. 2016
2016 Yeasts Associated with Culex pipiens and Culex theileri Mosquito Larvae and the Effect of Selected Yeast Strains on the Ontogeny of Culex pipiensMicrobial Ecology.  71:747-760. 2016
2016 Ergothioneine Maintains Redox and Bioenergetic Homeostasis Essential for Drug Susceptibility and Virulence of Mycobacterium tuberculosisCell Reports.  14:572-585. 2016
2016 Attenuated heme oxygenase-1 responses predispose the elderly to pulmonary nontuberculous mycobacterial infectionsAJP - Lung Cellular and Molecular Physiology.  311:L928-L940. 2016
2015 Host-directed therapies for tackling multi-drug resistant tuberculosis: Learning from the pasteur-bechamp debatesClinical Infectious Diseases.  61:1432-1438. 2015
2015 Metabolic plasticity of central carbon metabolism protects mycobacteriaProceedings of the National Academy of Sciences.  112:13135-13136. 2015
2015 Regulation of ergothioneine biosynthesis and its effect on Mycobacterium tuberculosis growth and infectivityJournal of Biological Chemistry.  290:23064-23076. 2015
2015 Towards host-directed therapies for tuberculosisNature Reviews Drug Discovery.  14:511-512. 2015
2014 Exposure to cigarette smoke impacts myeloid-derived regulatory cell function and exacerbates airway hyper-responsivenessLaboratory Investigation.  94:1312-1325. 2014
2014 The physiology and genetics of oxidative stress in mycobacteriaMicrobiology Spectrum.  2. 2014
2013 S100A8/A9 proteins mediate neutrophilic inflammation and lung pathology during tuberculosisAmerican Journal of Respiratory and Critical Care Medicine.  188:1137-1146. 2013
2012 Environmental heme-based sensor proteins: Implications for understanding bacterial pathogenesisAntioxidants and Redox Signaling.  17:1232-1245. 2012
2012 Heme oxygenase-1 promotes granuloma development and protects against dissemination of mycobacteriaLaboratory Investigation.  92:1541-1552. 2012
2012 Mycobacterium tuberculosis WhiB4 regulates oxidative stress response to modulate survival and dissemination in vivoMicrobiological sciences.  85:1148-1165. 2012
2012 Iron sulfur cluster proteins and microbial regulation: Implications for understanding tuberculosisCurrent Opinion in Chemical Biology.  16:45-53. 2012
2012 Mycobacterium tuberculosis WhiB3: A novel iron-sulfur cluster protein that regulates redox homeostasis and virulenceAntioxidants and Redox Signaling.  16:687-697. 2012
2011 A screen to identify small molecule inhibitors of protein-protein interactions in mycobacteriaASSAY and Drug Development Technologies.  9:299-310. 2011
2011 Redox homeostasis in mycobacteria: the key to tuberculosis control?Expert Reviews in Molecular Medicine.  13. 2011
2010 Conservation of structure and protein-protein interactions mediated by the secreted mycobacterial proteins EsxA, EsxB, and EspAJournal of Bacteriology.  192:326-335. 2010
2010 Reductive stress in microbes: Implications for understanding mycobacterium tuberculosis disease and persistenceAdvances in Microbial Physiology.  57:43-117. 2010
2009 Unexpected effects of starfish grazing on sandflat communities following an outbreakMarine Ecology Progress Series.  398:173-182. 2009
2009 Complex effects of the gastropod Assiminea globulus on benthic community structure in a marine-dominated lagoonJournal of Experimental Marine Biology and Ecology.  380:47-52. 2009
2009 Mycobacterium tuberculosis WhiB3 Maintains redox homeostasis by regulating virulence lipid anabolism to modulate macrophage responsePLoS Pathogens.  5. 2009
2008 Heme oxygenase-1-derived carbon monoxide induces the Mycobacterium tuberculosis dormancy regulonJournal of Biological Chemistry.  283:18032-18039. 2008
2007 A partner for the resuscitation-promoting factors of Mycobacterium tuberculosisMicrobiological sciences.  66:658-668. 2007
2007 Mycobacterium tuberculosis DosS is a redox sensor and DosT is a hypoxia sensorProceedings of the National Academy of Sciences.  104:11568-11573. 2007
2007 Mycobacterium tuberculosis WhiB3 responds to O2 and nitric oxide via its [4Fe-4S] cluster and is essential for nutrient starvation survivalProceedings of the National Academy of Sciences.  104:11562-11567. 2007
2006 Dissecting virulence pathways of Mycobacterium tuberculosis through protein-protein associationProceedings of the National Academy of Sciences.  103:11346-11351. 2006
2005 Evaluation of electrodialysis for the treatment of an industrial solid waste leachateDesalination.  186:273-289. 2005
2003 Nitrate removal with reverse osmosis in a rural area in South AfricaDesalination.  155:15-26. 2003
2003 Interaction of the sensor module of Mycobacterium tuberculosis H37Rv KdpD with members of the Lpr familyMicrobiological sciences.  47:1075-1089. 2003
2003 Cloning and characterization of a second α-amylase gene (LKA2) from Lipomyces kononenkoae IGC4052B and its expression in Saccharomyces cerevisiaeYeast.  20:69-78. 2003
2002 Mycobacterium tuberculosis WhiB3 interacts with RpoV to affect host survival but is dispensable for in vivo growthProceedings of the National Academy of Sciences.  99:3147-3152. 2002
2001 Investigation into alternative water treatment technologies for the treatment of underground mine water discharged by Grootvlei Proprietary Mines Ltd into the Blesbokspruit in South AfricaDesalination.  133:13-30. 2001
2000 Characterization of the Mycobacterium tuberculosis iniBAC promoter, a promoter that responds to cell wall biosynthesis inhibitionJournal of Bacteriology.  182:1802-1811. 2000
1999 Recent developments in mycobacterial researchCurrent Opinion in Infectious Diseases.  12:415-424. 1999
1996 Cloning, mapping and characterization of a genomic copy of the Lipomyces kononenkoae alpha-amylase-encoding gene (LKA1).Yeast.  12:925-937. 1996
1996 Cloning, mapping and characterization of a genomic copy of the Lipomyces kononenkoae α-amylase-encoding gene (LKA1)Yeast.  12:925-937. 1996
1996 Treatment using reverse osmosis of an effluent from stainless steel manufactureWater Research.  30:1979-1984. 1996
1995 Cloning, sequence analysis and expression in yeasts of a cDNA containing a Lipomyces kononenkoae α-amylase-encoding geneGene.  166:65-71. 1995
1995 Characterization of a novel α-amylase from Lipomyces kononenkoae and expression of its gene (LKA1) in Saccharomyces cerevisiaeCurrent Genetics.  28:526-533. 1995
1995 Expression of human p450c17 as an export protein in saccharomyces cerevisiaeEndocrine Research.  21:289-295. 1995
1993 Regional sequence homologies in starch-degrading enzymesCurrent Genetics.  24:400-407. 1993
1993 Expression and secretion of Bacillus amyloliquefaciens α-amylase by using the yeast pheromone α-factor promoter and leader sequence in Saccharomyces cerevisiaeApplied and Environmental Microbiology.  59:1253-1258. 1993
1991 Co-expression of a Saccharomyces diastaticus glucoamylase-encoding gene and a Bacillus amyloliquefaciens α-amylase-encoding gene in Saccharomyces cerevisiaeGene.  100:85-93. 1991

Chapter

Year Title Altmetric
2013 Protein-protein interaction in the-omics era: Understanding Mycobacterium tuberculosis function.  79-106. 2013

Research Overview

  • Tuberculosis
  • Principal Investigator On

  • Interplay Between the Mtb Electron Transport Chain and Carbon Metabolism  awarded by National Institute of Allergy and Infectious Diseases/NIH/DHHS 2018 - 2023
  • Hydrogen Sulfide and Tuberculosis Disease  awarded by National Institute of Allergy and Infectious Diseases/NIH/DHHS 2018 - 2022
  • Metabolic Reprogramming of T Cell Energy Metabolism in Tuberculosis and HIV  awarded by National Institute of Allergy and Infectious Diseases/NIH/DHHS 2018 - 2020
  • Heme Oxygenase–1 and the Bioenergetic Threshold of Latent TB and HIV Co-Infection  awarded by National Institute of Allergy and Infectious Diseases/NIH/DHHS 2015 - 2020
  • UAB - AHRI agreement for assignment of Dr Adries Steyn as a Scientist in Residence  awarded by AFRICA HEALTH RESEARCH INSTITUTE 2017 - 2019
  • HSF/GEF Scholar Award for Andries Steyn  awarded by UNIVERSITY OF ALABAMA HEALTH SERVICES FOUNDATION 2017 - 2018
  • Immunometabolism of M. Tuberculosis/HIV co-infection  awarded by National Institute of Allergy and Infectious Diseases/NIH/DHHS 2016 - 2018
  • Carbon Monoxide and Mycobacterium Tuberculosis Persistance  awarded by Burroughs Wellcome Fund 2008 - 2016
  • Role of WhiB3 in M. tuberculosis Virulence  awarded by National Institute of Allergy and Infectious Diseases/NIH/DHHS 2010 - 2016
  • Real Time Measurement of Host Bioenergetics During Mycobacterium Tuberculosis Infection  awarded by DOD - ARMY MEDICAL RESEARCH ACQUISITION ACTIVITY 2013 - 2015
  • Cigarette Smoke and Drug Resistant Tuberculosis  awarded by American Lung Association 2012 - 2014
  • Mechanism of Mycobacterium Tuberculosis Persistence  awarded by National Institute of Allergy and Infectious Diseases/NIH/DHHS 2009 - 2014
  • Fostering International Collaboration between US-Based Institutions and K-RITH at the University of Kwazulu-Natal in Durban, South Africa  awarded by Hughes (Howard) Medical Institute 2010 - 2011
  • Education And Training

  • Doctor of Philosophy in Microbiology, Stellenbosch University 1995
  • Full Name

  • Andries Steyn