Positions

Selected Publications

Academic Article

Year Title Altmetric
2018 Genome-wide DNA methylation encodes cardiac transcriptional reprogramming in human ischemic heart failure.Laboratory Investigation2018
2018 Glucagon Receptor Signaling Regulates Energy Metabolism via Hepatic Farnesoid X Receptor and Fibroblast Growth Factor 21.Diabetes.  67:1773-1782. 2018
2018 Antiretroviral therapy potentiates high-fat diet induced obesity and glucose intolerance.Molecular Metabolism.  12:48-61. 2018
2018 Temporal partitioning of adaptive responses of the murine heart to fasting.Life Sciences.  197:30-39. 2018
2018 Mitochondrial Reactive Oxygen Species in Lipotoxic Hearts Induce Post-Translational Modifications of AKAP121, DRP1, and OPA1 That Promote Mitochondrial Fission.Circulation Research.  122:58-73. 2018
2017 Gene expression analysis to identify mechanisms underlying heart failure susceptibility in mice and humans.Basic Research in Cardiology.  113:8. 2017
2017 Glucose transporter 4-deficient hearts develop maladaptive hypertrophy in response to physiological or pathological stresses.AJP - Heart and Circulatory Physiology.  313:H1098-H1108. 2017
2017 Genetic disruption of the cardiomyocyte circadian clock differentially influences insulin-mediated processes in the heart.Journal of Molecular and Cellular Cardiology.  110:80-95. 2017
2017 Diabetes-Related Cardiac Dysfunction.Endocrinology and Metabolism.  32:171-179. 2017
2017 Metabolic Origins of Heart Failure.JACC: Basic to Translational Science.  2:297-310. 2017
2017 O-GlcNAcylation and cardiovascular disease.Biochemical Society Transactions.  45:545-553. 2017
2017 My Sweetheart Is Broken: Role of Glucose in Diabetic Cardiomyopathy.Diabetes and Metabolism Journal.  41:1-9. 2017
2016 Redox biology and the interface between bioenergetics, autophagy and circadian control of metabolism.Free Radical Biology and Medicine.  100:94-107. 2016
2016 Post-translational modifications of the cardiac proteome in diabetes and heart failure.PROTEOMICS - Clinical Applications.  10:25-38. 2016
2015 Phosphoinositide dependent protein kinase 1 is required for exercise-induced cardiac hypertrophy but not the associated mitochondrial adaptations.Journal of Molecular and Cellular Cardiology.  89:297-305. 2015
2015 Unsticking the Broken Diabetic Heart: O-GlcNAcylation and Calcium Sensitivity.Diabetes.  64:3339-3341. 2015
2015 Enhanced cardiac Akt/protein kinase B signaling contributes to pathological cardiac hypertrophy in part by impairing mitochondrial function via transcriptional repression of mitochondrion-targeted nuclear genes.Molecular and Cellular Biology.  35:831-846. 2015
2015 Myocardial mitochondrial dysfunction in mice lacking adiponectin receptor 1.Basic Research in Cardiology.  110:37. 2015
2014 Insulin receptor substrates are essential for the bioenergetic and hypertrophic response of the heart to exercise training.Molecular and Cellular Biology.  34:3450-3460. 2014
2014 Cardiomyocyte-specific BMAL1 plays critical roles in metabolism, signaling, and maintenance of contractile function of the heart.Journal of Biological Rhythms.  29:257-276. 2014
2014 Maintaining PGC-1α expression following pressure overload-induced cardiac hypertrophy preserves angiogenesis but not contractile or mitochondrial function.Federation proceedings.  28:3691-3702. 2014
2014 GLUT1 deficiency in cardiomyocytes does not accelerate the transition from compensated hypertrophy to heart failure.Journal of Molecular and Cellular Cardiology.  72:95-103. 2014
2014 Intramuscular fat and inflammation differ in older adults: the impact of frailty and inactivity.Journal of Nutrition, Health and Aging.  18:532-538. 2014
2014 The absence of insulin signaling in the heart induces changes in potassium channel expression and ventricular repolarization.AJP - Heart and Circulatory Physiology.  306:H747-H754. 2014
2013 Insulin receptor substrate signaling suppresses neonatal autophagy in the heart.Journal of Clinical Investigation.  123:5319-5333. 2013
2013 APpEaLINg therapeutic target for obesity cardiomyopathy?Journal of Molecular and Cellular Cardiology.  63:165-168. 2013
2013 Inducible overexpression of GLUT1 prevents mitochondrial dysfunction and attenuates structural remodeling in pressure overload but does not prevent left ventricular dysfunction.Journal of the American Heart Association : Cardiovascular and Cerebrovascular Disease.  2:e000301. 2013
2013 Regulation of fatty acid metabolism by mTOR in adult murine hearts occurs independently of changes in PGC-1α.AJP - Heart and Circulatory Physiology.  305:H41-H51. 2013
2013 Absence of glucose transporter 4 diminishes electrical activity of mouse hearts during hypoxia.Experimental Physiology.  98:746-757. 2013
2013 Regional muscle glucose uptake remains elevated one week after cessation of resistance training independent of altered insulin sensitivity response in older adults with type 2 diabetes.Journal of Endocrinological Investigation.  36:111-117. 2013
2013 Cardiac PI3K-Akt impairs insulin-stimulated glucose uptake independent of mTORC1 and GLUT4 translocation.Molecular Endocrinology -Baltimore-.  27:172-184. 2013
2013 Metabolic determinants of electrical failure in ex-vivo canine model of cardiac arrest: evidence for the protective role of inorganic pyrophosphate.PLoS ONE.  8:e57821. 2013
2012 Mechanisms of lipotoxicity in the cardiovascular system.Current Hypertension Reports.  14:517-531. 2012
2012 Genetic loss of insulin receptors worsens cardiac efficiency in diabetes.Journal of Molecular and Cellular Cardiology.  52:1019-1026. 2012
2012 Cytosolic, but not mitochondrial, oxidative stress is a likely contributor to cardiac hypertrophy resulting from cardiac specific GLUT4 deletion in mice.European Journal of Biochemistry.  279:599-611. 2012
2011 The maximal downstroke of epicardial potentials as an index of electrical activity in mouse hearts.IEEE Transactions on Biomedical Engineering.  58:3175-3183. 2011
2011 PGC-1β deficiency accelerates the transition to heart failure in pressure overload hypertrophy.Circulation Research.  109:783-793. 2011
2011 Expression of slow skeletal TnI in adult mouse hearts confers metabolic protection to ischemia.Journal of Molecular and Cellular Cardiology.  51:236-243. 2011
2011 Knockout of insulin receptors in cardiomyocytes attenuates coronary arterial dysfunction induced by pressure overload.AJP - Heart and Circulatory Physiology.  300:H374-H381. 2011
2010 Loss of bradykinin signaling does not accelerate the development of cardiac dysfunction in type 1 diabetic akita mice.Endocrinology.  151:3536-3542. 2010
2010 Preferential oxidation of triacylglyceride-derived fatty acids in heart is augmented by the nuclear receptor PPARalpha.Circulation Research.  107:233-241. 2010
2010 Aberrant water homeostasis detected by stable isotope analysis.PLoS ONE.  5:e11699. 2010
2010 Lipotoxicity in the heart.BBA - Biochimica et Biophysica Acta.  1801:311-319. 2010
2008 Insulin-like growth factor I receptor signaling is required for exercise-induced cardiac hypertrophy.Molecular Endocrinology -Baltimore-.  22:2531-2543. 2008
2007 A role for the transcriptional coactivator PGC-1alpha in muscle refueling.Journal of Biological Chemistry.  282:36642-36651. 2007
2007 Cardiac hypertrophy caused by peroxisome proliferator- activated receptor-gamma agonist treatment occurs independently of changes in myocardial insulin signaling.Endocrinology.  148:6047-6053. 2007
2007 A conserved role for phosphatidylinositol 3-kinase but not Akt signaling in mitochondrial adaptations that accompany physiological cardiac hypertrophy.Cell Metabolism.  6:294-306. 2007
2006 Diminished hepatic gluconeogenesis via defects in tricarboxylic acid cycle flux in peroxisome proliferator-activated receptor gamma coactivator-1alpha (PGC-1alpha)-deficient mice.Journal of Biological Chemistry.  281:19000-19008. 2006
2005 PGC-1alpha coactivates PDK4 gene expression via the orphan nuclear receptor ERRalpha: a mechanism for transcriptional control of muscle glucose metabolism.Molecular and Cellular Biology.  25:10684-10694. 2005
2005 PGC-1alpha deficiency causes multi-system energy metabolic derangements: muscle dysfunction, abnormal weight control and hepatic steatosis.PLoS Biology.  3:e101. 2005
2004 Calcineurin and calcium/calmodulin-dependent protein kinase activate distinct metabolic gene regulatory programs in cardiac muscle.Journal of Biological Chemistry.  279:39593-39603. 2004
2002 Adaptations of skeletal muscle to exercise: rapid increase in the transcriptional coactivator PGC-1.Federation proceedings.  16:1879-1886. 2002

Education And Training

  • Doctor of Philosophy in Cell / Cellular and Molecular Biology, Washington University/St. Louis
  • Full Name

  • Adam Wende
  • Blazerid

  • arwende