Positions

Selected Publications

Academic Article

Year Title Altmetric
2019 Widespread diminishing anthropogenic effects on calcium in freshwaters 2019
2019 Growth hormone (GH) receptor (GHR)-specific inhibition of GH-Induced signaling by soluble IGF-1 receptor (sol IGF-1R) 2019
2019 Early glomerular hyperfiltration and long-term kidney outcomes in type 1 diabetes: The DCCT/EDIC experience 2019
2019 Mesenchymal Niche-Specific Expression of Cxcl12 Controls Quiescence of Treatment-Resistant Leukemia Stem Cells 2019
2019 Risk factors for kidney disease in type 1 diabetes 2019
2019 Genetic determinants of glycated hemoglobin in type 1 diabetes 2019
2019 Biological and geochemical changes in shallow lakes of the Hudson Bay Lowlands: a response to recent warming 2019
2019 Skin autofluorescence predicts incident type 2 diabetes, cardiovascular disease and mortality in the general population 2019
2019 Climate variability promotes unprecedented cyanobacterial blooms in a remote, oligotrophic Ontario lake: evidence from paleolimnology 2019
2019 SIRT1 regulates metabolism and leukemogenic potential in CML stem cells 2019
2018 Diatom responses to 20th century shoreline development and climate warming in three embayments of Georgian Bay, Lake Huron 2018
2018 State of the climate in 2017 2018
2018 Crustacean zooplankton in lakes of the far north of Ontario, Canada 2018
2018 Reduced phosphorus retention by anoxic bottom sediments after the remediation of an industrial acidified lake area: Indications from P, Al, and Fe sediment fractions 2018
2018 The post-glacial history of northern Lake of the Woods: A multi-proxy perspective on climate variability and lake ontogeny 2018
2018 Oxidative stress and cardiovascular risk in type 1 diabetes mellitus: Insights from the DCCT/EDIC study 2018
2018 Historical trends, drivers, and future projections of ice phenology in small north temperate lakes in the Laurentian Great Lakes Region 2018
2018 Holocene history of Lake of the Woods: Ontario, Manitoba, and Minnesota 2018
2018 Increased relative abundance of colonial scaled chrysophytes since pre-industrial times in minimally disturbed lakes from the experimental Lakes Area, Ontario 2018
2017 Inferring Past Trends in Lake Water Organic Carbon Concentrations in Northern Lakes Using Sediment Spectroscopy 2017
2017 An introduction to Lake of the Woods—from science to governance in an international waterbody 2017
2017 Climate as a driver of increasing algal production in Lake of the Woods, Ontario, Canada 2017
2017 Historical phosphorus dynamics in Lake of the Woods (USA–Canada) — does legacy phosphorus still affect the southern basin? 2017
2017 State of the climate in 2016 2017
2017 Polygenic transmission disequilibrium confirms that common and rare variation act additively to create risk for autism spectrum disorders 2017
2017 Skin autofluorescence, a non-invasive biomarker for advanced glycation end products, is associated with the metabolic syndrome and its individual components 2017
2017 Meta-analysis of GWAS of over 16,000 individuals with autism spectrum disorder highlights a novel locus at 10q24.32 and a significant overlap with schizophrenia 2017
2017 Response of periphytic diatom communities to multiple stressors influencing lakes in the Muskoka River Watershed, Ontario, Canada 2017
2017 Scale and watershed features determine lake chemistry patterns across physiographic regions in the far north of Ontario, Canada 2017
2016 Managing lake trout lakes in a warming world: a paleolimnological assessment of nutrients and lake production at three Ontario sites 2016
2016 Seasonal and decadal patterns in Discostella (Bacillariophyceae) species from bi-weekly records of two boreal lakes (Experimental Lakes Area, Ontario, Canada) 2016
2016 Tracking the long-term responses of diatoms and cladocerans to climate warming and human influences across lakes of the Ring of Fire in the Far North of Ontario, Canada 2016
2016 State of the climate in 2015 2016
2016 Temporal changes in cladoceran assemblages subjected to a low calcium environment: combining the sediment record with long-term monitoring data 2016
2016 Significance of epicardial and intrathoracic adipose tissue volume among type 1 diabetes patients in the DCCT/EDIC: A pilot study 2016
2016 Corrigendum to: Why is the relative abundance of Asterionella formosa increasing in a Boreal Shield lake as nutrient levels decline? (J Paleolimnol, 2016, 55, (357-367), 10.1007/s10933-016-9886-2) 2016
2016 Why is the relative abundance of Asterionella formosa increasing in a Boreal Shield lake as nutrient levels decline? 2016
2016 Albuminuria changes and cardiovascular and renal outcomes in type 1 diabetes: The DCCT/EDIC study 2016
2015 Differences among modern-day and historical cladoceran communities from the "ring of Fire" lake region of northern Ontario: Identifying responses to climate warming 2015
2015 Microbial DNA records historical delivery of anthropogenic mercury 2015
2015 Long-term stability of cladoceran assemblages in small, shallow, Canadian Shield lakes experiencing marked calcium declines 2015
2015 Altered pH and reduced calcium levels drive near extirpation of native crayfish, Cambarus bartonii, in Algonquin Park, Ontario, Canada 2015
2015 State of the climate in 2014 2015
2015 Lake diatom responses to warming: reviewing the evidence 2015
2015 A global database of lake surface temperatures collected by in situ and satellite methods from 1985-2009 2015
2015 Forecasting cyanobacteria dominance in Canadian temperate lakes 2015
2015 Psychiatric genome-wide association study analyses implicate neuronal, immune and histone pathways 2015
2015 Joint analysis of psychiatric disorders increases accuracy of risk prediction for schizophrenia, bipolar disorder, and major depressive disorder 2015
2015 Long-term successional changes in peatlands of the Hudson Bay Lowlands, Canada inferred from the ecological dynamics of multiple proxies 2015
2014 The influence of water-table depth and ph on the spatial distribution of diatom species in peatlands of the boreal shield and hudson plains, canada 2014
2014 The jellification of north temperate lakes 2014
2014 O-GlcNAc transferase is critical for transducin-like enhancer of split (TLE)-mediated repression of canonicalwntsignaling 2014
2014 Functional collaboration of insulin-like growth factor-1 receptor (IGF-1R), but not insulin receptor (IR), with acute GH signaling in mouse calvarial cells 2014
2014 A multi-trophic exploratory survey of recent environmental changes using lake sediments in the Hudson Bay Lowlands, Ontario, Canada 2014
2014 An exploratory survey of summer water chemistry and plankton communities in lakes near the Sutton River, Hudson Bay Lowlands, Ontario, Canada 2014
2014 Introduction-environmental change in the Hudson and James Bay region 2014
2014 Climate warming alters thermal stability but not stratification phenology in a small north-temperate lake 2014
2014 Human gh Receptor-Igf-1 receptor interaction: Implications for gh signaling 2014
2014 Human gh Receptor-Igf-1 receptor interaction: Implications for gh signaling 2014
2014 Potential factors leading to the formation of cyanobacterial scums in a mesotrophic softwater lake in Ontario, Canada 2014
2014 The influence of calcium decline and climate change on the cladocerans within low calcium, circumneutral lakes of the Experimental Lakes Area 2014
2014 Trends in surface water chemistry in acidified areas in Europe and North America from 1990 to 2008 2014
2013 IGF-1R modulation of acute GH-induced STAT5 signaling: Role of protein tyrosine phosphatase activity 2013
2013 Evidence for microbially mediated production of elemental mercury (Hg0) in subarctic lake sediments 2013
2013 Effects of multiple stressors on lakes in south-central Ontario: 15 years of change in lakewater chemistry and sedimentary diatom assemblages 2013
2013 The interplay of local and regional factors in generating temporal changes in the ice phenology of dickie lake, south-central ontario, canada 2013
2013 Aquatic Ecosystem Responses to Rapid Recovery from Extreme Acidification and Metal Contamination in Lakes Near Wawa, Ontario 2013
2013 Recent changes in mercury deposition and primary productivity inferred from sediments of lakes from the Hudson Bay Lowlands, Ontario, Canada 2013
2013 Global warming triggers the loss of a key Arctic refugium 2013
2012 Glucose deprivation-induced increase in protein O-GlcNAcylation in cardiomyocytes is calcium-dependent 2012
2012 Scaled-chrysophyte assemblage changes in the sediment records of lakes recovering from marked acidification and metal contamination near Wawa, Ontario, Canada 2012
2012 Changes since the onset of acid deposition among calcium-sensitive cladoceran taxa within softwater lakes of Ontario, Canada 2012
2012 Cladoceran response to calcium decline and the subsequent inadvertent liming of a softwater canadian lake 2012
2012 Dramatic diatom species assemblage responses in lakes recovering from acidification and metal contamination near wawa, Ontario, Canada: A paleolimnological perspective 2012
2012 Crustacean zooplankton sedimentary remains from calcium-poor lakes: Complex responses to threshold concentrations 2012
2012 Multiple stressor effects on water quality in Poplar Bay, Lake of the Woods, Canada: A midge-based assessment of hypolimnetic oxygen conditions over the last two centuries 2012
2011 A total phosphorus budget for the Lake of the Woods and the Rainy River catchment 2011
2011 Assessment of benthic algal biomonitoring protocols to evaluate effects of shoreline development on the nearshore zone of Precambrian Shield lakes in Ontario 2011
2011 Examining 20th century water quality and ecological changes in the Lake of the Woods, Ontario, Canada: A paleolimnological investigation 2011
2011 Changes in diatom assemblages since pre-industrial times in 40 reference lakes from the Experimental Lakes Area (northwestern Ontario, Canada) 2011
2011 Water quality changes in south-central Ontario lakes and the role of local factors in regulating lake response to regional stressors 2011
2011 Changes in the thermal stability of Lake Simcoe from 1980 to 2008 2011
2011 Diatoms as indicators of long-term nutrient enrichment in metal-contaminated urban lakes from Sudbury, Ontario 2011
2011 Muscle-specific overexpression of NCOATGK, splice variant of O-GlcNAcase, induces skeletal muscle atrophy 2011
2011 Assessing the effects of multiple environmental stressors on zooplankton assemblages in Boreal Shield lakes since pre-industrial times 2011
2011 Direct and indirect effects of an invasive planktonic predator on pelagic food webs 2011
2010 Reorganization of algal communities in the Lake of the Woods (Ontario, Canada) in response to turn-of-the-century damming and recent warming 2010
2010 Study of Heart and Renal Protection (SHARP): Randomized trial to assess the effects of lowering low-density lipoprotein cholesterol among 9,438 patients with chronic kidney disease 2010
2010 Designing and implementing sample and data collection for an international genetics study: The Type 1 Diabetes Genetics Consortium (T1DGC) 2010
2010 Sudbury sediments revisited: Evaluating limnological recovery in a multiple-stressor environment 2010
2010 A comparison of pre-industrial and present-day changes in Bosmina and Daphnia size structure from soft-water Ontario lakes 2010
2010 Environmental stability and lake zooplankton diversity - contrasting effects of chemical and thermal variability 2010
2010 Mercury empirical relationships in sediments from three Ontario lakes 2010
2010 Assessing variability in total phosphorus measurements in Ontario lakes 2010
2010 O-GlcNAcylation enhances FOXO4 transcriptional regulation in response to stress 2010
2010 Do spectrally inferred determinations of chlorophyll a reflect trends in lake trophic status? 2010
2009 Dissecting the spatial scales of mercury accumulation in Ontario lake sediment 2009
2009 Long-term declines in phosphorus export from forested catchments in south-central Ontario 2009
2009 Increased O-GlcNAc causes disrupted lens fiber cell differentiation and cataracts 2009
2009 Assessing hypolimnetic oxygen concentrations in Canadian Shield lakes: Deriving management benchmarks using two methods 2009
2009 Temporal analysis of net fluvial methylmercury loading in a dystrophic and a clear water lake 2009
2009 Thiazolidinediones mimic glucose starvation in facilitating Sp1 degradation through the up-regulation of β-transducin repeat-containing protein 2009
2009 Genome-wide association study and meta-analysis find that over 40 loci affect risk of type 1 diabetes 2009
2009 Factors influencing the achievement of steady state in mercury contamination among lakes and catchments of south-central Ontario 2009
2009 Protein O-GlcNAcylation: A new signaling paradigm for the cardiovascular system 2009
2008 The widespread threat of calcium decline in fresh waters 2008
2008 Hemispheric-scale patterns of climate-related shifts in planktonic diatoms from North American and European lakes 2008
2008 An introduction to the Dorset special issue: Transforming understanding of factors that regulate aquatic ecosystems on the southern Canadian Shield 2008
2008 Long-term assessments of ecological effects of anthropogenic stressors on aquatic ecosystems from paleoecological analyses: Challenges to perspectives of lake management 2008
2008 Long-term changes in phytoplankton composition in seven Canadian Shield lakes in response to multiple anthropogenic stressors 2008
2008 Long-term trends in zooplankton of Dorset, Ontario, lakes: The probable interactive effects of changes in pH, total phosphorus, dissolved organic carbon, and predators 2008
2008 Relationships between dissolved organic carbon concentrations, weather, and acidification in small Boreal Shield lakes 2008
2008 Temporal and spatial concordance in community composition of phytoplankton, zooplankton, macroinvertebrate, crayfish, and fish on the Precambrian Shield 2008
2008 Calcium levels in Daphnia ephippia cannot provide a useful paleolimnological indicator of historical lakewater Ca concentrations 2008
2008 Cladocera assemblages from the surface sediments of south-central Ontario (Canada) lakes and their relationships to measured environmental variables 2008
2008 Linking mean body size of pelagic Cladocera to environmental variables in Precambrian Shield lakes: A paleolimnological approach 2008
2007 Metabolic control of proteasome function 2007
2007 Proteasome function is regulated by cyclic AMP-dependent protein kinase through phosphorylation of Rpt6 2007
2006 O-GlcNAc integrates the proteasome and transcriptome to regulate nuclear hormone receptors 2006
2006 Disrupting the enzyme complex regulating O-GlcNAcylation blocks signaling and development 2006
2006 Location and characterization of the O-GlcNAcase active site 2006
2006 The histone acetyltransferase NCOAT contains a zinc finger-like motif involved in substrate recognition 2006
2006 Streptozotocin inhibits O-GlcNAcase via the production of a transition state analog 2006
2006 A review of the components, coefficients and technical assumptions of ontario's lakeshore capacity model 2006
2006 Lake sediment core records of sulphur accumulation and sulphur isotopic composition in central Ontario, Canada lakes 2006
2005 Assessing scales of variability in benthic diatom community structure 2005
2005 Proteolytic processing of TGFα redirects its mitogenic activity: The membrane-anchored form is autocrine, the secreted form is paracrine 2005
2005 Climate-driven regime shifts in the biological communities of arctic lakes 2005
2005 Induction of KLF4 in basal keratinocytes blocks the proliferation- differentiation switch and initiates squamous epithelial dysplasia 2005
2005 Spatial variability in water quality and surface sediment diatom assemblages in a complex lake basin: Lake of the Woods, Ontario, Canada 2005
2004 Characterization of the histone acetyltransferase (HAT) domain of a bifunctional protein with activable O-GlcNAcase and HAT activities 2004
2004 Phosphorylation of mouse glutamine-fructose-6-phosphate amidotransferase 2 (GFAT2) by cAMP-dependent protein kinase increases the enzyme activity 2004
2004 Accumulation of protein O-GlcNAc modification inhibits proteasomes in the brain and coincides with neuronal apoptosis in brain areas with high c-GlcNAc metabolism 2004
2004 Marked recent increases of colonial scaled chrysophytes in boreal lakes: Implications for the management of taste and odour events 2004
2003 O-GlcNAc modification is an endogenous inhibitor of the proteasome 2003
2003 Assignment of N-acetyl-D-glucosaminidase (Mgea5) to rat chromosome 1q5 by tyramide fluorescence in situ hybridization (T-FISH): Synteny between rat, mouse and human with Insulin Degradation Enzyme (IDE) 2003
2003 A landscape approach to examining spatial patterns of limnological variables and long-term environmental change in a southern Canadian lake district 2003
2003 Diatom and chrysophyte algal response to long-term PCB contamination from a point-source in Northern Labrador, Canada 2003
2002 A paleolimnological investigation of the effects of forest fire on lake water quality in northwestern Ontario over the past ca. 150 years 2002
2002 Streptozotocin, an O-GlcNAcase inhibitor, blunts insulin and growth hormone secretion 2002
2002 The importance of model choice on pH inferences from scaled chrysophyte assemblages in North America 2002
2001 Scaled chrysophytes as indicators of water quality changes since preindustrial times in the Muskoka-Haliburton region, Ontario, Canada 2001
2001 O-linkage of N-acetylglucosamine to Sp1 activation domain inhibits its transcriptional capability 2001
2001 Beneficial effects of intensive therapy of diabetes during adolescence: Outcomes after the conclusion of the Diabetes Control and Complications Trial (DCCT) 2001
2001 Stage-sensitive blockade of pituitary somatomammotrope development by targeted expression of a dominant negative epidermal growth factor receptor in transgenic mice 2001
2000 Phosphorylation of human glutamine:fructose-6-phosphate amidotransferase by cAMP-dependent protein kinase at serine 205 blocks the enzyme activity 2000
2000 Evaluation of the genetic component of variability in CYP3A4 activity: A repeated drug administration method 2000
2000 Human Sug1/p45 is involved in the proteasome-dependent degradation of Sp1 2000
2000 Glucose stimulates protein modification by O-linked GlcNAc in pancreatic β cells: Linkage of O-linked GlcNAc to β cell death 2000
1999 Conditional expression of the ErbB2 oncogene elicits reversible hyperplasia in stratified epithelia and up-regulation of TGFα expression in transgenic mice 1999
1999 An N-terminal region of Sp1 targets its proteasome-dependent degradation in vitro 1999
1998 Streptozotocin, an analog of N-acetylglucosamine, blocks the removal of O-GlcNAc from intracellular proteins 1998
1998 Targeted expression of activated erbB-2 to the epidermis of transgenic mice elicits striking developmental abnormalities in the epidermis and hair follicles 1998
1998 Sex ratio of offspring of diabetics (multiple letters) [8] 1998
1998 Assessment of the effects of logging, forest fires and drought on lakes in northwestern Ontario: A 30-year paleolimnological perspective 1998
1997 MDA468 growth inhibition by EGF is associated with the induction of the cyclin-dependent kinase inhibitor p21(WAF1) 1997
1997 Targeted expression of a dominant negative epidermal growth factor receptor in the mammary gland of transgenic mice inhibits pubertal mammary duct development 1997
1996 Role of glucosamine synthesis in the stimulation of TGF-α gene transcription by glucose and EGF 1996
1995 Childhood antecedents of schizophrenia 1995
1995 Sequence of the functional human keratin K14 promoter 1995
1995 Childhood antecedents of schizophrenia [11] 1995
1995 Regulation of glutamine:fructose-6-phosphate amidotransferase gene transcription by epidermal growth factor and glucose 1995
1995 Targeting of transforming growth factor-alpha expression to pituitary lactotrophs in transgenic mice results in selective lactotroph proliferation and adenomas 1995
1995 p53 stimulates transcription from the human transforming growth factor α promoter: A potential growth-stimulatory role for p53 1995
1994 The murine glutamine:fructose-6-phosphate amidotransferase-encoding cDNA sequence 1994
1994 Human immunodeficiency virus 1 Tat stimulates transcription of the transforming growth factor α gene in an epidermal growth factor-dependent manner 1994
1993 Glucose regulation of transforming growth factor-α expression is mediated by products of the hexosamine biosynthesis pathway 1993
1992 5-Azacytidine treatment of HA-A melanoma cells induces Sp1 activity and concomitant transforming growth factor α expression 1992
1992 Cost benefits of low dose subcutaneous erythropoietin in patients with anaemia of end stage renal disease 1992
1992 Glucose and glucosamine regulate growth factor gene expression in vascular smooth muscle cells 1992
1991 The attitudes of heroin users and matched non-users to drugs and drug users 1991
1991 Transcriptional regulation of the human transforming growth factor-α gene 1991
1990 Transforming growth factor α in arterioles: Cell surface processing of its precursor by elastases 1990
1989 Inhibition of stimulus-dependent epidermal growth factor receptor and transforming growth factor-α mRNA accumulation by the protein kinase C inhibitor staurosporine 1989
1989 Phorbol ester or epidermal growth factor (EGF) stimulates the concurrent accumulation of mRNA for the EGF receptor and its ligand transforming growth factor-α in a breast cancer cell line 1989
1989 Transforming growth factor-α in the mammalian brain. Immunohistochemical detection in neurons and characterization of its mRNA 1989
1988 Regulation of EGF receptor and transforming growth factor-alpha expression. 1988

Full Name

  • Andrew Paterson