Positions

Selected Publications

Academic Article

Year Title Altmetric
2014 Human GH receptor-IGF-1 receptor interaction: implications for GH signaling.Molecular Endocrinology -Baltimore-.  28:1841-1854. 2014
2014 O-GlcNAc transferase is critical for transducin-like enhancer of split (TLE)-mediated repression of canonical Wnt signaling.Journal of Biological Chemistry.  289:12168-12176. 2014
2014 Functional collaboration of insulin-like growth factor-1 receptor (IGF-1R), but not insulin receptor (IR), with acute GH signaling in mouse calvarial cells.Endocrinology.  155:1000-1009. 2014
2014 Human gh Receptor-Igf-1 receptor interaction: Implications for gh signalingMolecular Endocrinology -Baltimore-.  28:1841-1854. 2014
2013 IGF-1R modulation of acute GH-induced STAT5 signaling: role of protein tyrosine phosphatase activity.Molecular Endocrinology -Baltimore-.  27:1969-1979. 2013
2012 Glucose deprivation-induced increase in protein O-GlcNAcylation in cardiomyocytes is calcium-dependent.Journal of Biological Chemistry.  287:34419-34431. 2012
2011 Muscle-specific overexpression of NCOATGK, splice variant of O-GlcNAcase, induces skeletal muscle atrophy.American Journal of Physiology - Cell Physiology.  300:C456-C465. 2011
2010 O-GlcNAcylation enhances FOXO4 transcriptional regulation in response to stress.FEBS Letters.  584:49-54. 2010
2009 Increased O-GlcNAc causes disrupted lens fiber cell differentiation and cataracts.Biochemical and Biophysical Research Communications.  387:70-76. 2009
2009 Thiazolidinediones mimic glucose starvation in facilitating Sp1 degradation through the up-regulation of beta-transducin repeat-containing protein.Molecular Pharmacology.  76:47-57. 2009
2009 Protein O-GlcNAcylation: a new signaling paradigm for the cardiovascular system.AJP - Heart and Circulatory Physiology.  296:H13-H28. 2009
2007 Metabolic control of proteasome function.News in Physiological Sciences.  22:373-379. 2007
2007 Proteasome function is regulated by cyclic AMP-dependent protein kinase through phosphorylation of Rpt6.Journal of Biological Chemistry.  282:22460-22471. 2007
2006 O-GlcNAc integrates the proteasome and transcriptome to regulate nuclear hormone receptors.Molecular and Cellular Biology.  26:8539-8550. 2006
2006 Disrupting the enzyme complex regulating O-GlcNAcylation blocks signaling and development.Glycobiology.  16:551-563. 2006
2006 Location and characterization of the O-GlcNAcase active site.BBA - Biochimica et Biophysica Acta.  1760:829-839. 2006
2006 The histone acetyltransferase NCOAT contains a zinc finger-like motif involved in substrate recognition.Journal of Biological Chemistry.  281:3918-3925. 2006
2006 Streptozotocin inhibits O-GlcNAcase via the production of a transition state analog.Biochemical and Biophysical Research Communications.  340:526-534. 2006
2005 Proteolytic processing of TGFalpha redirects its mitogenic activity: the membrane-anchored form is autocrine, the secreted form is paracrine.BBA - Biochimica et Biophysica Acta.  1743:231-242. 2005
2005 Induction of KLF4 in basal keratinocytes blocks the proliferation-differentiation switch and initiates squamous epithelial dysplasia.Oncogene.  24:1491-1500. 2005
2004 Characterization of the histone acetyltransferase (HAT) domain of a bifunctional protein with activable O-GlcNAcase and HAT activities.Journal of Biological Chemistry.  279:53665-53673. 2004
2004 Phosphorylation of mouse glutamine-fructose-6-phosphate amidotransferase 2 (GFAT2) by cAMP-dependent protein kinase increases the enzyme activity.Journal of Biological Chemistry.  279:29988-29993. 2004
2004 Accumulation of protein O-GlcNAc modification inhibits proteasomes in the brain and coincides with neuronal apoptosis in brain areas with high O-GlcNAc metabolism.Journal of Neurochemistry.  89:1044-1055. 2004
2003 O-GlcNAc modification is an endogenous inhibitor of the proteasome.Cell.  115:715-725. 2003
2003 Assignment of N-acetyl-D-glucosaminidase (Mgea5) to rat chromosome 1q5 by tyramide fluorescence in situ hybridization (T-FISH): synteny between rat, mouse and human with Insulin Degradation Enzyme (IDE).Cytogenetics and Cell Genetics.  103:202B. 2003
2002 Streptozotocin, an O-GlcNAcase inhibitor, blunts insulin and growth hormone secretion.Molecular and Cellular Endocrinology.  194:135-146. 2002
2001 O-linkage of N-acetylglucosamine to Sp1 activation domain inhibits its transcriptional capability.Proceedings of the National Academy of Sciences.  98:6611-6616. 2001
2001 Stage-sensitive blockade of pituitary somatomammotrope development by targeted expression of a dominant negative epidermal growth factor receptor in transgenic mice.Molecular Endocrinology -Baltimore-.  15:600-613. 2001
2000 Phosphorylation of human glutamine:fructose-6-phosphate amidotransferase by cAMP-dependent protein kinase at serine 205 blocks the enzyme activity.Journal of Biological Chemistry.  275:21981-21987. 2000
2000 Human Sug1/p45 is involved in the proteasome-dependent degradation of Sp1.Biochemical Journal.  348 Pt 2:281-289. 2000
2000 Glucose stimulates protein modification by O-linked GlcNAc in pancreatic beta cells: linkage of O-linked GlcNAc to beta cell death.Proceedings of the National Academy of Sciences.  97:2820-2825. 2000
1999 Conditional expression of the ErbB2 oncogene elicits reversible hyperplasia in stratified epithelia and up-regulation of TGFalpha expression in transgenic mice.Oncogene.  18:3593-3607. 1999
1999 An N-terminal region of Sp1 targets its proteasome-dependent degradation in vitro.Journal of Biological Chemistry.  274:15194-15202. 1999
1998 Streptozotocin, an analog of N-acetylglucosamine, blocks the removal of O-GlcNAc from intracellular proteins.Proceedings of the Association of American Physicians.  110:422-432. 1998
1998 Targeted expression of activated erbB-2 to the epidermis of transgenic mice elicits striking developmental abnormalities in the epidermis and hair follicles.Cell Growth and Differentiation.  9:313-325. 1998
1997 MDA468 growth inhibition by EGF is associated with the induction of the cyclin-dependent kinase inhibitor p21(WAF1)Anticancer Research.  17:2627-2633. 1997
1997 Targeted expression of a dominant negative epidermal growth factor receptor in the mammary gland of transgenic mice inhibits pubertal mammary duct developmentMolecular Endocrinology -Baltimore-.  11:1765-1781. 1997
1996 Role of glucosamine synthesis in the stimulation of TGF-α gene transcription by glucose and EGFAmerican Journal of Physiology - Cell Physiology.  270. 1996
1995 Targeting of transforming growth factor-alpha expression to pituitary lactotrophs in transgenic mice results in selective lactotroph proliferation and adenomas.Endocrinology.  136:4479-4488. 1995
1995 p53 stimulates transcription from the human transforming growth factor alpha promoter: a potential growth-stimulatory role for p53.Molecular and Cellular Biology.  15:4694-4701. 1995
1995 Regulation of glutamine:fructose-6-phosphate amidotransferase gene transcription by epidermal growth factor and glucose.Endocrinology.  136:2809-2816. 1995
1995 Sequence of the functional human keratin K14 promoter.Gene.  153:297-298. 1995
1994 The murine glutamine:fructose-6-phosphate amidotransferase-encoding cDNA sequence.Gene.  140:289-290. 1994
1994 Human immunodeficiency virus 1 Tat stimulates transcription of the transforming growth factor alpha gene in an epidermal growth factor-dependent manner.Cell Growth and Differentiation.  5:87-93. 1994
1993 Glucose regulation of transforming growth factor-α expression is mediated by products of the hexosamine biosynthesis pathwayMolecular Endocrinology -Baltimore-.  7:1041-1048. 1993
1992 5-Azacytidine treatment of HA-A melanoma cells induces Sp1 activity and concomitant transforming growth factor alpha expression.Molecular and Cellular Biology.  12:3998-4006. 1992
1992 Glucose and glucosamine regulate growth factor gene expression in vascular smooth muscle cells.Proceedings of the National Academy of Sciences.  89:8150-8154. 1992
1991 Transcriptional regulation of the human transforming growth factor-alpha gene.Molecular Endocrinology -Baltimore-.  5:514-520. 1991
1990 Transforming growth factor alpha in arterioles: cell surface processing of its precursor by elastases.Molecular and Cellular Biology.  10:4596-4602. 1990
1989 Phorbol ester or epidermal growth factor (EGF) stimulates the concurrent accumulation of mRNA for the EGF receptor and its ligand transforming growth factor-alpha in a breast cancer cell line.Journal of Biological Chemistry.  264:4021-4027. 1989
1989 Transforming growth factor-alpha in the mammalian brain. Immunohistochemical detection in neurons and characterization of its mRNA.Journal of Biological Chemistry.  264:3880-3883. 1989
1989 Inhibition of stimulus-dependent epidermal growth factor receptor and transforming growth factor-alpha mRNA accumulation by the protein kinase C inhibitor staurosporine.FEBS Letters.  243:404-408. 1989
1988 Regulation of EGF receptor and transforming growth factor-alpha expression.Advances in Experimental Medicine and Biology.  234:105-126. 1988

Education And Training

  • Doctor of Philosophy in Biochemistry, University of Canterbury
  • Master of Sciences or Mathematics in Chemistry, University of Canterbury
  • Full Name

  • Andrew Paterson
  • Blazerid

  • andypat