Positions

Overview

  • The Pickering lab is interested in the role of proteostasis, particularly the proteasome in aging and neurodegenerative diseases. Proteostasis is critical for a wide range of neuronal and non-neuronal functions. As we get older many of these proteostatic functions decline. This is even greater in Alzheimer's and Parkinson's disease. We've found that prevention of neuronal proteostatic decline (both both drug and pharmacologic) can extend animal lifespan and protect against age-related cognitive declines and reduce Alzheimer’s disease like pathology in multiple model systems.
  • Selected Publications

    Academic Article

    Year Title Altmetric
    2020 New Peptide-Based Pharmacophore Activates 20S ProteasomeMolecules.  26:1439-1439. 2020
    2020 New peptide-based pharmacophore activates 20S proteasomeMolecules.  25. 2020
    2019 Neuronal‐specific proteasome augmentation via Prosβ5 overexpression extends lifespan and reduces age‐related cognitive declineAging Cell.  18. 2019
    2019 Cause or casualty: The role of mitochondrial DNA in aging and age- associated disease 2019
    2018 Proline- and arginine-rich peptides as flexible allosteric modulators of human proteasome activityJournal of Medicinal Chemistry2018
    2017 Mitochondrial thioredoxin reductase 2 is elevated in long-lived primate as well as rodent species and extends fly mean lifespan.Aging Cell2017
    2015 Fibroblasts From Longer-Lived Species of Primates, Rodents, Bats, Carnivores, and Birds Resist Protein Damage 2015
    2015 Mouse and primate lifespan is correlated with immunoproteasome expressionJournal of Clinical Investigation2015
    2013 Oxidative Stress Adaption with Acute, Chronic and Repeated StressFree Radical Biology and Medicine2013
    2013 A Conserved Role for the 20S Proteasome and Nrf2 Transcription Factor in Oxidative-Stress Adaptation in Mammals, C. elegans and D. melanogaster. 2013
    2012 Differential roles of proteasome and immunoproteasome regulators Pa28αβ, Pa28γ and Pa200 in the degradation of oxidized proteinsArchives of Biochemistry and Biophysics.  523:181-190. 2012
    2012 A simple fluorescence labeling method for studies of protein oxidation, protein modification, and proteolysisFree Radical Biology and Medicine.  52:239-246. 2012
    2012 Degradation of damaged proteins: the main function of the 20S proteasomeProgress in Molecular Biology and Translational Science.  109. 2012
    2012 Nrf2-dependent Induction of Proteasome and Pa28αβ Regulator Are Required for Adaptation to Oxidative StressJournal of Biological Chemistry.  23:10021-31. 2012
    2011 HSP70 mediates dissociation and reassociation of the 26S proteasome during adaptation to oxidative stressFree Radical Biology and Medicine.  51:1355-1364. 2011
    2010 The immunoproteasome, the 20S proteasome, and the PA28aß proteasome regulator are oxidative stress-adaptive proteolytic complexes.Biochemical Journal.  51:585-594. 2010
    2009 Natural genetic variation in transcriptome reflects network structure inferred with major effect mutations: insulin/TOR and associated phenotypes in Drosophila melanogasterBMC Genomics.  10:124-124. 2009

    Chapter

    Year Title Altmetric
    2017 The immunoproteasome system in aging, lifespan and age associated disease. 2017

    Research Overview

  • We use cell culture, fruit flies, mice and human tissue to investigate the role of proteostasis in aging and neurodegenerative disease. We are also interested in development of pharmacolgic targets which can prevent proteostatic deficits.
  • Education And Training

  • Doctor of Philosophy in Molecular Biology, University of Southern California 2012
  • University of Michigan–Ann Arbor, Postdoctoral Fellowship 2016
  • University of California Los Angeles, Postdoctoral Fellowship 2013
  • Full Name

  • Andrew Pickering