• Dr. Singal is an Associate Professor of Medicine and Director of the UAB Porphyria Center. He is board certified in internal medicine, gastroenterology, and transplant hepatology. Dr. Singal is a leading expert in alcoholic liver disease and his other research interests include non-alcoholic fatty liver disease, porphyria, and acute kidney injury in cirrhosis. In addition to various industry sponsored clinical trials, he is the PI on translational research studies funded by the American College of Gastroenterology, NIAAA and NIDDK of the NIH. He collaborates within UAB with the free radical center, O'Brien center of acute kidney injury, genetics core, and microbiome core, and outside UAB with the NIAAA funded consortia on alcoholic hepatitis. He serves on many national committees including practice guidelines of the American College of Gastroenterology and research award committees of the American Association for Study of Liver Diseases and the American Gastroenterological Association. In addition, Dr. Singal regularly mentors medical students, residents and fellows with regular presentations at the national meetings helping them to advance in their respective careers.
  • Selected Publications

    Academic Article

    Year Title Altmetric
    2019 Feasibility of cellular bioenergetics as a biomarker in porphyria patients.Molecular Genetics and Metabolism Reports.  19:100451. 2019
    2019 Current trials and novel therapeutic targets for alcoholic hepatitis.Journal of Hepatology.  70:305-313. 2019
    2019 Epidemiology of Alcohol Consumption and Societal Burden of Alcoholism and Alcoholic Liver Disease.Clinics in Liver Disease.  23:39-50. 2019
    2019 Porphyria cutanea tarda: Recent update.Molecular Genetics and Metabolism2019
    2019 DAAs prevent HCC – the plot thickensDigestive and Liver Disease2019
    2019 FXR deficiency and alcoholic liver disease: Tissue is the issueDigestive and Liver Disease2019
    2019 Impact of Nonmalignant Portal Vein Thrombosis in Transplant Recipients With Nonalcoholic Steatohepatitis.Liver Transplantation and Surgery.  25:68-78. 2019
    2019 Response to Forrest et al.American Journal of Gastroenterology.  114:176. 2019
    2018 Cellular Abnormalities and Emerging Biomarkers in Alcohol-Associated Liver Disease.Gene Expression: International Journal of Molecular and Cellular Science.  19:49-60. 2018
    2018 Simultaneous liver kidney transplantation.Transplant International2018
    2018 A Validated Score Predicts Acute Kidney Injury and Survival in Patients With Alcoholic Hepatitis.Liver Transplantation and Surgery.  24:1655-1664. 2018
    2018 Editorial: direct anti-viral agents, hepatitis C virus eradication, and gut-liver axis-another mechanistic piece to the puzzle.Alimentary Pharmacology and Therapeutics.  48:1321-1322. 2018
    2018 Genetic and Epigenetic Culprits in the Pathogenesis of Nonalcoholic Fatty Liver Disease.Journal of Clinical and Experimental Hepatology.  8:390-402. 2018
    2018 Light to moderate drinking and therapeutic doses of acetaminophen: An assessment of risks for renal dysfunction.Preventive Medicine Reports.  12:253-258. 2018
    2018 Relapse of porphyria cutanea tarda after treatment with phlebotomy or 4-aminoquinoline antimalarials: a meta-analysis.British Journal of Dermatology.  179:1351-1357. 2018
    2018 Heavy Alcohol Use Among Deceased Donors Does Not Impact Recipient Outcomes After Liver Transplantation.Transplantation.  102:1864-1869. 2018
    2018 Strong correlation of ferrochelatase enzymatic activity with Mitoferrin-1 mRNA in lymphoblasts of patients with protoporphyria.Molecular Genetics and Metabolism2018
    2018 Grand Rounds: Alcoholic Hepatitis.Journal of Hepatology.  69:534-543. 2018
    2018 Pharmacological Therapies for Hepatorenal Syndrome: A Systematic Review and Meta-Analysis.Journal of Clinical Gastroenterology.  52:360-367. 2018
    2018 Hepatitis C Virus and Hepatocellular Carcinoma: A Narrative Review.Journal of Clinical and Translational Hepatology.  6:79-84. 2018
    2018 Alcohol Relapse After Liver Transplantation for Alcoholic Cirrhosis-Impact on Liver Graft and Patient Survival: A Meta-analysis.Alcohol and Alcoholism.  53:166-172. 2018
    2018 ACG Clinical Guideline: Alcoholic Liver Disease.American Journal of Gastroenterology.  113:175-194. 2018
    2018 Biomarkers of Renal Injury in Cirrhosis: Association with Acute Kidney Injury and Recovery after Liver Transplantation.Nephron.  138:1-12. 2018
    2018 Correction: Patients with stage 3 compared to stage 4 liver fibrosis have lower frequency of and longer time to liver disease complications.PLoS ONE.  13:e0199402. 2018
    2018 MELD Stratified Outcomes Among Recipients With Diabetes or Hypertension: Simultaneous Liver Kidney Versus Liver Alone.Journal of Clinical Gastroenterology.  52:67-72. 2018
    2018 Patients with stage 3 compared to stage 4 liver fibrosis have lower frequency of and longer time to liver disease complications.PLoS ONE.  13:e0197117. 2018
    2017 Severe Alcoholic Hepatitis: Atypical Presentation with Markedly Elevated Alkaline Phosphatase.Journal of Clinical and Translational Hepatology.  5:414-415. 2017
    2017 Text messaging approach improves weight loss in patients with nonalcoholic fatty liver disease: A randomized study.Liver International.  38:924-931. 2017
    2017 Cardiovascular mortality among liver transplant recipients with nonalcoholic steatohepatitis in the United States-a retrospective study.Transplant International.  30:1051-1060. 2017
    2017 Clinical, Biochemical, and Genetic Characterization of North American Patients With Erythropoietic Protoporphyria and X-linked Protoporphyria.JAMA Dermatology.  153:789-796. 2017
    2017 Hepatitis C Treatment in Patients With Porphyria Cutanea Tarda.American Journal of the Medical Sciences.  353:523-528. 2017
    2017 Primary biliary cirrhosis has high wait-list mortality among patients listed for liver transplantation.Transplant International.  30:454-462. 2017
    2017 Infection in Severe Alcoholic Hepatitis: Yet Another Piece in the Puzzle.Gastroenterology.  152:938-940. 2017
    2017 Unusually High Rates of Hepatocellular Carcinoma After Treatment With Direct-Acting Antiviral Therapy for Hepatitis C Related Cirrhosis.Gastroenterology.  152:911-912. 2017
    2017 Live donor liver transplantation for alcoholic hepatitis.Hepatology International.  11:34-37. 2017
    2017 Reply to ''Alcohol and Liver Transplantation''.Alcohol and Alcoholism.  52:127. 2017
    2016 PNPLA3 polymorphism increases risk for and severity of chronic hepatitis C liver disease.World Journal of Hepatology.  8:1584-1592. 2016
    2016 Alcohol Use after Liver Transplantation is Independent of Liver Disease Etiology.Alcohol and Alcoholism.  51:698-701. 2016
    2016 Hepatic porphyria: A narrative review.Indian Journal of Gastroenterology.  35:405-418. 2016
    2016 PNPLA3 as a Genetic Determinant of Risk for and Severity of Non-alcoholic Fatty Liver Disease Spectrum.Journal of Clinical and Translational Hepatology.  4:175-191. 2016
    2016 Diagnosis and Treatment of Alcoholic Hepatitis: A Systematic Review.Alcoholism: Clinical and Experimental Research.  40:1390-1402. 2016
    2016 Ammonia level at admission predicts in-hospital mortality for patients with alcoholic hepatitis.Gastroenterology Report.  5:232-236. 2016
    2016 Corticosteroids and occurrence of and mortality from infections in severe alcoholic hepatitis: a meta-analysis of randomized trials.Liver International.  36:721-728. 2016
    2016 Alcoholic liver disease presents at advanced stage and progresses faster compared to non-alcoholic fatty liver diseas.Annals of hepatology.  15:183-189. 2016
    2016 Nonalcoholic Steatohepatitis is the Most Rapidly Growing Indication for Simultaneous Liver Kidney Transplantation in the United States.Transplantation.  100:607-612. 2016
    2016 Frequency of Cardiovascular Events and Effect on Survival in Liver Transplant Recipients for Cirrhosis Due to Alcoholic or Nonalcoholic Steatohepatitis.Experimental and Clinical Transplantation.  14:79-85. 2016
    2016 Therapeutic Strategies for the Treatment of Alcoholic Hepatitis.Seminars in Liver Disease.  36:56-68. 2016
    2015 Autoimmune Markers Do Not Impact Clinical Presentation or Natural History of Steatohepatitis-Related Liver Disease.Digestive Diseases and Sciences.  60:3788-3793. 2015
    2015 Pitfalls in Erythrocyte Protoporphyrin Measurement for Diagnosis and Monitoring of Protoporphyrias.Clinical Chemistry.  61:1453-1456. 2015
    2015 Liver transplantation for alcoholic hepatitis: A survey of liver transplant centers.Liver Transplantation and Surgery.  21:1449-1452. 2015
    2015 Comparative Effectiveness of Pharmacological Interventions for Severe Alcoholic Hepatitis: A Systematic Review and Network Meta-analysis.Gastroenterology.  149:958-70.e12. 2015
    2015 Acute Kidney Injury in Patients with Cirrhosis.Journal of Clinical and Translational Hepatology.  3:195-204. 2015
    2015 PNPLA3 Gene Polymorphism Is Associated With Predisposition to and Severity of Alcoholic Liver Disease.American Journal of Gastroenterology.  110:846-856. 2015
    2015 Management of hepatocellular carcinoma.Journal of Cancer Research and Clinical Oncology.  141:861-876. 2015
    2015 Impact of all oral anti-hepatitis C virus therapy: A meta-analysis.World Journal of Hepatology.  7:806-813. 2015
    2015 Outcomes of liver transplantation alone after listing for simultaneous kidney: comparison to simultaneous liver kidney transplantation.Transplantation.  99:823-828. 2015
    2015 Diabetes Mellitus Predicts Occurrence of Cirrhosis and Hepatocellular Cancer in Alcoholic Liver and Non-alcoholic Fatty Liver Diseases.Journal of Clinical and Translational Hepatology.  3:9-16. 2015
    2015 Erratum: PNPLA3 gene polymorphism is associated with predisposition to and severity of alcoholic liver disease (Am J Gastroenterol 110:846-856(2015) DOI: 10.1038/ajg.2015.137)American Journal of Gastroenterology.  110:1121. 2015
    2015 Surveillance and Diagnosis of Hepatocellular Carcinoma.Gastroenterology and Hepatology -New York-.  11:38-46. 2015
    2014 Alcoholic hepatitis and concomitant hepatitis C virus infection.World Journal of Gastroenterology.  20:11929-11934. 2014
    2014 Outcomes after liver transplantation for combined alcohol and hepatitis C virus infection.World Journal of Gastroenterology.  20:11935-11938. 2014
    2014 Editorial: sepsis in cirrhosis - there may be trouble ahead; authors' reply.Alimentary Pharmacology and Therapeutics.  40:567-568. 2014
    2014 Liver transplantation in the management of porphyria.Hepatology.  60:1082-1089. 2014
    2014 Mesenteric venous thrombosis.Journal of Clinical and Experimental Hepatology.  4:257-263. 2014
    2014 The Bioenergetic Health Index: a new concept in mitochondrial translational research.Clinical Science.  127:367-373. 2014
    2014 Evolving frequency and outcomes of simultaneous liver kidney transplants based on liver disease etiology.Transplantation.  98:216-221. 2014
    2014 Prevalence and in-hospital mortality trends of infections among patients with cirrhosis: a nationwide study of hospitalised patients in the United States.Alimentary Pharmacology and Therapeutics.  40:105-112. 2014
    2014 Alcoholic hepatitis: current challenges and future directions.Clinical Gastroenterology and Hepatology.  12:555-564. 2014
    2014 Optimal management of alcoholic hepatitis.Minerva Gastroenterologica e Dietologica.  60:25-38. 2014
    2014 Current management of alcoholic liver disease.Current Drug Abuse Reviews.  7:18-28. 2014
    2014 Regorafenib: an evidence-based review of its potential in patients with advanced liver cancer.Core Evidence.  9:81-87. 2014
    2013 Liver transplantation in alcoholic liver disease current status and controversies.World Journal of Gastroenterology.  19:5953-5963. 2013
    2013 Outcome after liver transplantation for cirrhosis due to alcohol and hepatitis C: comparison to alcoholic cirrhosis and hepatitis C cirrhosis.Journal of Clinical Gastroenterology.  47:727-733. 2013
    2013 Nutritional status of patients with alcoholic cirrhosis undergoing liver transplantation: time trends and impact on survival.Transplant International.  26:788-794. 2013
    2013 Meta-analysis: the impact of oral anti-viral agents on the incidence of hepatocellular carcinoma in chronic hepatitis B.Alimentary Pharmacology and Therapeutics.  38:98-106. 2013
    2013 Management practices of hepatitis C virus infected alcoholic hepatitis patients: A survey of physicians.World Journal of Gastrointestinal Pharmacology and Therapeutics.  4:16-22. 2013
    2013 Evolving frequency and outcomes of liver transplantation based on etiology of liver disease.Transplantation.  95:755-760. 2013
    2013 Model for End-stage Liver DiseaseJournal of Clinical and Experimental Hepatology.  3:50-60. 2013
    2013 Primary care physicians and disparities in colorectal cancer screening in the elderly.Health Services Research.  48:95-113. 2013
    2013 Recent trends in the epidemiology of alcoholic liver diseaseClinical Liver Disease.  2:53-56. 2013
    2012 Low-dose hydroxychloroquine is as effective as phlebotomy in treatment of patients with porphyria cutanea tarda.Clinical Gastroenterology and Hepatology.  10:1402-1409. 2012
    2012 Nutrition in alcoholic liver disease.Clinics in Liver Disease.  16:805-826. 2012
    2012 Hepatitis C virus infection in alcoholic hepatitis: prevalence patterns and impact on in-hospital mortality.European Journal of Gastroenterology and Hepatology.  24:1178-1184. 2012
    2012 Hepatocellular carcinoma predicts in-hospital mortality from acute variceal hemorrhage among patients with cirrhosis.Journal of Clinical Gastroenterology.  46:613-619. 2012
    2012 Outcomes after liver transplantation for alcoholic hepatitis are similar to alcoholic cirrhosis: exploratory analysis from the UNOS database.Hepatology.  55:1398-1405. 2012
    2012 Racial disparities in treatment for pancreatic cancer and impact on survival: a population-based analysis.Journal of Cancer Research and Clinical Oncology.  138:715-722. 2012
    2012 Meta-analysis: oral anti-viral agents in adults with decompensated hepatitis B virus cirrhosis.Alimentary Pharmacology and Therapeutics.  35:674-689. 2012
    2011 Liver transplantation in acute alcoholic hepatitis: Current status and future developmentWorld Journal of Hepatology.  3:215-218. 2011
    2011 Self-expanding metal stents for biliary drainage in patients with resectable pancreatic cancer: single-center experience with 79 cases.Digestive Diseases and Sciences.  56:3678-3684. 2011
    2011 Antioxidants as therapeutic agents for liver disease.Liver International.  31:1432-1448. 2011
    2011 Alcoholic hepatitis: prognostic models and treatment.Gastroenterology Clinics of North America.  40:611-639. 2011
    2011 Natural history of small duct primary sclerosing cholangitis: a case series with review of the literature.Hepatology International.  5:808-813. 2011
    2011 Corticosteroids and pentoxifylline for the treatment of alcoholic hepatitis: Current status.World Journal of Hepatology.  3:205-210. 2011
    2011 Peginterferon alfa-2a is superior to peginterferon alfa-2b in the treatment of naïve patients with hepatitis C virus infection: meta-analysis of randomized controlled trials.Digestive Diseases and Sciences.  56:2221-2226. 2011
    2011 Intra-hepatic cholangiocarcinoma--frequency and demographic patterns: thirty-year data from the M.D. Anderson Cancer Center.Journal of Cancer Research and Clinical Oncology.  137:1071-1078. 2011
    2011 Comment on a systematic review of randomized trials of peginterferon alpha-2a versus peginterferon alpha-2b in chronic hepatitis C.Hepatology.  53:2151. 2011
    2011 Impact of hepatitis C virus infection on the course and outcome of patients with acute alcoholic hepatitis.European Journal of Gastroenterology and Hepatology.  23:204-209. 2011
    2010 Meta-analysis: interferon improves outcomes following ablation or resection of hepatocellular carcinoma.Alimentary Pharmacology and Therapeutics.  32:851-858. 2010
    2010 Tailoring treatment duration to 12 to 16 weeks in hepatitis C genotype 2 or 3 with rapid virologic response: systematic review and meta-analysis of randomized controlled trials.Journal of Clinical Gastroenterology.  44:583-587. 2010
    2010 Comment on ACG Guidelines--Management of alcoholic liver disease.American Journal of Gastroenterology.  105:1449-1450. 2010
    2010 Erratum: Duplex doppler ultrasound examination of the portal venous system: An emerging novel technique for the estimation of portal vein pressure (Digestive Diseases and Sciences DOI: 10.1007/s10620-009-0887-0)Digestive Diseases and Sciences.  55:1808. 2010
    2010 Comments on AASLD practice guidelines for alcoholic liver disease.Hepatology.  51:1860-1861. 2010
    2010 Duplex Doppler ultrasound examination of the portal venous system: an emerging novel technique for the estimation of portal vein pressure.Digestive Diseases and Sciences.  55:1230-1240. 2010
    2010 Antiviral therapy reduces risk of hepatocellular carcinoma in patients with hepatitis C virus-related cirrhosis.Clinical Gastroenterology and Hepatology.  8:192-199. 2010
    2010 Percutaneous transesophageal gastrostomy tube placement: an alternative to percutaneous endoscopic gastrostomy in patients with intra-abdominal metastasis.Gastrointestinal Endoscopy.  71:402-406. 2010
    2010 Type of pegylated interferon matters: another milestone in the treatment of hepatitis C virus infection.Hepatitis Monthly.  10:165-167. 2010
    2009 Management of hepatitis C virus infection in HIV/HCV co-infected patients: clinical review.World Journal of Gastroenterology.  15:3713-3724. 2009
    2009 Bilhemia after trans-jugular intra-hepatic porto-systemic shunt and its management with biliary decompression.World Journal of Gastroenterology.  15:3681-3683. 2009
    2009 Hepatitis A vaccine is not required in adult patients with chronic liver disease in Saudi Arabia.Singapore Medical Journal.  50:442-443. 2009
    2008 Silent cirrhosis in hepatitis B virus related hepatocellular carcinoma.Acta hepato-splenologica.  55:1734-1737. 2008
    2008 Prevalence and factors affecting occurrence of type 2 diabetes mellitus in Saudi patients with chronic liver diseaseSaudi Journal of Gastroenterology.  14:118-121. 2008
    2007 Use of splenic artery embolization to relieve tense ascites following liver transplantation in a patient with paroxysmal nocturnal hemoglobinuria.Liver Transplantation and Surgery.  13:1532-1537. 2007
    2007 Mechanisms of synergy between alcohol and hepatitis C virus.Journal of Clinical Gastroenterology.  41:761-772. 2007
    2007 Anorectal stimulation causes increased colonic motor activity in subjects with spinal cord injury.Journal of Spinal Cord Medicine.  30:31-35. 2007


    Year Title Altmetric
    2015 Transplantation for Nonalcoholic Steatohepatitis.  250-255. 2015
    2014 Variceal hemorrhage.  145-158. 2014

    Research Overview

  • Alcohol related liver disease
    Alcoholic hepatitis
    Fatty liver disease
    Hepatorenal Syndrome
  • Investigator On

  • Private Grant  awarded by SC LIVER RESEARCH CONSORTIUM 2017 - 2024
  • Private Grant  awarded by SILLAJEN BIOTHERAPEUTICS 2017 - 2022
  • Private Grant  awarded by Gilead Sciences 2015 - 2021
  • Private Grant  awarded by CONATUS PHARMACEUTICALS, INC. 2017 - 2021
  • Acute Liver Failure Study Group 13C- Methacetin Breath Test for the Prediction of Acute Liver Failure  awarded by University of Texas Southwestern Medical Center at Dallas 2016 - 2020
  • The Guts of HIV: Innate Immune Dysregulation as a Central Mechanism of Gastrointestinal and Liver Disease in HIV-1-Infected Individuals  awarded by National Institute of Diabetes and Digestive and Kidney Diseases/NIH/DHHS 2015 - 2020
  • Private Grant  awarded by CONATUS PHARMACEUTICALS, INC. 2016 - 2020
  • Alabama Coalition for Testing, Interventions and Engagement in Hepatitis C Care (ACTIVE-Care)  awarded by GILEAD FOUNDATION 2017 - 2019
  • Translational Bioenergetics in Patients with Alcoholic Liver Disease  awarded by National Institute on Alcohol Abuse and Alcoholism/NIH/DHHS 2015 - 2018
  • Private Grant  awarded by SC LIVER RESEARCH CONSORTIUM 2016 - 2018
  • Private Grant  awarded by ALNYLAM PHARMACEUTICALS, INC. 2016 - 2017
  • Alabama Coalition for Testing, Interventions, and Engagement in Hepatitis C Care (ACTIVE-Care)  awarded by GILEAD FOUNDATION 2015 - 2017
  • Private Grant  awarded by ALNYLAM PHARMACEUTICALS, INC. 2014 - 2017
  • Porphyria Rare Disease Clinical Research Consortium (RDCRC)  awarded by Mount Sinai School of Medicine 2014 - 2017
  • A Phase 2A Study to Evaluate the Safety and Tolerability of OCR-002 (Ornithine Phenylacetate) in the Treatment of Patients with Acute Liver Failure/Severe Acute Liver Injury (STOP-ALF)  awarded by University of Texas Southwestern Medical Center at Dallas 2015 - 2016
  • Private Grant  awarded by SALIX PHARMACEUTICALS, INC. 2013 - 2015
  • Private Grant  awarded by SALIX PHARMACEUTICALS, INC. 2013 - 2015
  • Private Grant  awarded by Gilead Sciences 2015
  • Private Grant  awarded by OCERA THERAPEUTICS, INC. 2013 - 2014
  • Private Grant  awarded by SALIX PHARMACEUTICALS, INC. 2013 - 2014
  • Private Grant  awarded by VITAL THERAPIES, INC 2012 - 2014
  • Education And Training

  • Bachelor of Medicine & Surgery (MBBS), Institution Not Available in List
  • Doctor of Medicine in Internal Medicine Residency Program, Postgraduate Institute of Medical Education and Research
  • Full Name

  • Ashwani Singal