Positions

Overview

  • We use laboratory mice to investigate the neuronal and molecular substrates that govern motivation, palatability, taste, and ingestion to develop novel and more effective treatments for obesity and eating disorders. Combined with neural circuit tools like optogenetics, chemogenetics, and biosensors, our work maps neural circuit function onto discrete aspects of conserved feeding behavior. hardawaylab.org
  • Selected Publications

    Academic Article

    Year Title Altmetric
    2020 Manipulations of Central Amygdala Neurotensin Neurons Alter the Consumption of Ethanol and Sweet Fluids in Mice 2020
    2020 Kappa opioid receptor and dynorphin signaling in the central amygdala regulates alcohol intake 2020
    2019 Central Amygdala Prepronociceptin-Expressing Neurons Mediate Palatable Food Consumption and Reward 2019
    2019 Erratum: Central Amygdala Prepronociceptin-Expressing Neurons Mediate Palatable Food Consumption and Reward (Neuron (2019)102(5)(1037–1052.e7), (S0896627319303265), (10.1016/j.neuron.2019.03.037)) 2019
    2019 Dopamine-dependent, swimming-induced paralysis arises as a consequence of loss of function mutations in the RUNX transcription factor RNT-1 2019
    2018 Acute engagement of Gq-mediated signaling in the bed nucleus of the stria terminalis induces anxiety-like behavior 2018
    2018 Metabolic mapping of downstream network activity following CNO-induced activation of hM3Dq in BNST VGAT neurons 2018
    2017 Metallo-β-lactamase Domain-Containing Protein 1 (MBLAC1) Is a Specific, High-Affinity Target for the Glutamate Transporter Inducer Ceftriaxone 2017
    2017 The atypical MAP kinase SWIP-13/ERK8 regulates dopamine transporters through a Rho-dependent mechanism 2017
    2017 Sequence determinants of the Caenhorhabditis elegans dopamine transporter dictating in vivo axonal export and synaptic localization 2017
    2016 Acute blockade of the Caenorhabditis elegans dopamine transporter DAT-1 by the mammalian norepinephrine transporter inhibitor nisoxetine reveals the influence of genetic modifications of dopamine signaling in vivo 2016
    2016 Serotonin engages an anxiety and fear-promoting circuit in the extended amygdala 2016
    2016 Nociceptin receptor antagonist SB 612111 decreases high fat diet binge eating 2016
    2016 Dynorphin Controls the Gain of an Amygdalar Anxiety Circuit 2016
    2015 Integrated circuits and molecular components for stress and feeding: Implications for eating disorders 2015
    2014 An open-source analytical platform for analysis of C. elegans swimming-induced paralysis 2014
    2014 LIM Domain Only-2 (LMO2) induces T-cell leukemia by two distinct pathways 2014
    2012 Forward genetic analysis to identify determinants of dopamine signaling in caenorhabditis elegans using swimming-induced paralysis 2012

    Research Overview

  • Systems Neuroscience
    Behavioral Neuroscience
    Obesity
    Eating Disorders
  • Education And Training

  • Doctor of Philosophy in Neuroscience, Vanderbilt University 2013
  • Bachelor of Arts in Biology, Hendrix College 2006
  • Full Name

  • J. Andrew Hardaway