Selected Publications

Academic Article

Year Title Altmetric
2019 Mks6 mutations reveal tissue-and cell type-specific roles for the cilia transition zoneFederation proceedings.  33:1440-1455. 2019
2018 Autosomal dominant retinitis pigmentosa rhodopsin mutant Q344X drives specific alterations in chromatin complex gene transcriptionMolecular Vision.  24:153-164. 2018
2016 Aberrant protein trafficking in retinal degenerations: The initial phase of retinal remodelingExperimental Eye Research.  150:71-80. 2016
2016 Novel hypomorphic alleles of the mouse tyrosinase gene induced by CRISPR-Cas9 nucleases cause non-albino pigmentation phenotypesPLoS ONE.  11. 2016
2014 Nucleotide bound to rab11a controls localization in rod cells but not interaction with rhodopsinJournal of Neuroscience.  34:14854-14863. 2014
2014 Abrupt onset of mutations in a developmentally regulated gene during terminal differentiation of post-mitotic photoreceptor neurons in micePLoS ONE.  9. 2014
2014 An activated unfolded protein response promotes retinal degeneration and triggers an inflammatory response in the mouse retinaCell Death and Disease.  5. 2014
2013 Biochemical analysis of a rhodopsin photoactivatable GFP fusion as a model of G-protein coupled receptor transportVision Research.  93:43-48. 2013
2013 The age-regulating protein klotho is vital to sustain retinal functionInvestigative Ophthalmology & Visual Science.  54:6675-6685. 2013
2013 The severe autosomal dominant retinitis pigmentosa rhodopsin mutant Ter349Glu mislocalizes and induces rapid rod cell deathJournal of Biological Chemistry.  288:29047-29055. 2013
2012 Defective trafficking of rhodopsin and its role in retinal degenerationsInternational Review of Cell and Molecular Biology.  293:1-44. 2012
2012 In vitro biochemical assays to monitor rhodopsin functionMethods in Molecular Biology.  884:167-181. 2012
2012 In vitro biochemical assays to monitor rhodopsin functionMethods in Molecular Biology.  884:167-181. 2012
2010 Mutations of the opsin gene (Y102H and I307N) lead to light-induced degeneration of photoreceptors and constitutive activation of phototransduction in miceJournal of Biological Chemistry.  285:14521-14533. 2010
2008 Identification and functional characterization of a novel rhodopsin mutation associated with autosomal dominant CSNBInvestigative Ophthalmology & Visual Science.  49:4105-4114. 2008
2006 Defective development of photoreceptor membranes in a mouse model of recessive retinal degenerationVision Research.  46:4510-4518. 2006
2005 Rhodopsin-EGFP knock-ins for imaging quantal gene alterationsVision Research.  45:3445-3453. 2005
2004 Evolution guided mutagenesis of rhodopsinInvestigative Ophthalmology & Visual Science.  45:U183-U183. 2004
2004 Functional Studies of a human rhodopsin-EGFP fusion in knock-in mice.Investigative Ophthalmology & Visual Science.  45:U183-U183. 2004
2004 Evolutionary Trace of G Protein-coupled Receptors Reveals Clusters of Residues That Determine Global and Class-specific FunctionsJournal of Biological Chemistry.  279:8126-8132. 2004
2003 An opsin mutant with increased thermal stabilityBiochemistry.  42:1995-2001. 2003
2003 Characterization of rhodopsin congenital night blindness mutant T94IBiochemistry.  42:2009-2015. 2003
2003 Slow binding of retinal to rhodopsin mutants G90D and T94DBiochemistry.  42:2002-2008. 2003

Education And Training

  • Doctor of Philosophy in Biochemistry, Brandeis University 2002
  • Full Name

  • Alecia Gutierrez