Positions

Selected Publications

Academic Article

Year Title Altmetric
2019 Mks6 mutations reveal tissue- and cell type-specific roles for the cilia transition zone.Federation proceedings.  33:1440-1455. 2019
2018 Autosomal dominant retinitis pigmentosa rhodopsin mutant Q344X drives specific alterations in chromatin complex gene transcription.Molecular Vision.  24:153-164. 2018
2016 Novel Hypomorphic Alleles of the Mouse Tyrosinase Gene Induced by CRISPR-Cas9 Nucleases Cause Non-Albino Pigmentation Phenotypes.PLoS ONE.  11:e0155812. 2016
2015 Aberrant protein trafficking in retinal degenerations: The initial phase of retinal remodeling.Experimental Eye Research.  150:71-80. 2015
2014 An activated unfolded protein response promotes retinal degeneration and triggers an inflammatory response in the mouse retina.Cell Death and Disease.  5:e1578. 2014
2014 Nucleotide bound to rab11a controls localization in rod cells but not interaction with rhodopsin.Journal of Neuroscience.  34:14854-14863. 2014
2014 Abrupt onset of mutations in a developmentally regulated gene during terminal differentiation of post-mitotic photoreceptor neurons in mice.PLoS ONE.  9:e108135. 2014
2013 Biochemical analysis of a rhodopsin photoactivatable GFP fusion as a model of G-protein coupled receptor transport.Vision Research.  93:43-48. 2013
2013 The age-regulating protein klotho is vital to sustain retinal function.Investigative Ophthalmology & Visual Science.  54:6675-6685. 2013
2013 The severe autosomal dominant retinitis pigmentosa rhodopsin mutant Ter349Glu mislocalizes and induces rapid rod cell death.Journal of Biological Chemistry.  288:29047-29055. 2013
2012 Defective trafficking of rhodopsin and its role in retinal degenerations.International Review of Cell and Molecular Biology.  293:1-44. 2012
2012 In vitro biochemical assays to monitor rhodopsin functionMethods in Molecular Biology.  884:167-181. 2012
2012 In vitro biochemical assays to monitor rhodopsin function.Methods in Molecular Biology.  884:167-181. 2012
2010 Mutations of the opsin gene (Y102H and I307N) lead to light-induced degeneration of photoreceptors and constitutive activation of phototransduction in mice.Journal of Biological Chemistry.  285:14521-14533. 2010
2008 Identification and functional characterization of a novel rhodopsin mutation associated with autosomal dominant CSNB.Investigative Ophthalmology & Visual Science.  49:4105-4114. 2008
2006 Defective development of photoreceptor membranes in a mouse model of recessive retinal degeneration.Vision Research.  46:4510-4518. 2006
2005 Rhodopsin-EGFP knock-ins for imaging quantal gene alterations.Vision Research.  45:3445-3453. 2005
2004 Evolution guided mutagenesis of rhodopsinInvestigative Ophthalmology & Visual Science.  45:U183-U183. 2004
2004 Functional Studies of a human rhodopsin-EGFP fusion in knock-in mice.Investigative Ophthalmology & Visual Science.  45:U183-U183. 2004
2004 Evolutionary trace of G protein-coupled receptors reveals clusters of residues that determine global and class-specific functions.Journal of Biological Chemistry.  279:8126-8132. 2004
2003 An opsin mutant with increased thermal stability.Biochemistry.  42:1995-2001. 2003
2003 Characterization of rhodopsin congenital night blindness mutant T94I.Biochemistry.  42:2009-2015. 2003
2003 Slow binding of retinal to rhodopsin mutants G90D and T94D.Biochemistry.  42:2002-2008. 2003

Teaching Activities

  • GBS792 - CMDB Seminar (Spring Term 2019) 2019
  • GBSC742 - Student Theme Meeting Course (Spring Term 2019) 2019
  • VIS700 - Vision-Related Lit Review (Spring Term 2019) 2019
  • GBS792 - CMDB Seminar (Fall Term 2018) 2018
  • GBSC742 - Student Theme Meeting Course (Fall Term 2018) 2018
  • VIS700 - Vision-Related Lit Review (Fall Term 2018) 2018
  • VS113 - Biochemistry of the Eye (Fall Term 2018) 2018
  • GBS792 - CMDB Seminar (Spring Term 2018) 2018
  • VIS700 - Vision-Related Lit Review (Spring Term 2018) 2018
  • GBS792 - CMDB Seminar (Fall Term 2017) 2017
  • VIS700 - Vision-Related Lit Review (Fall Term 2017) 2017
  • VS113 - Biochemistry of the Eye (Fall Term 2017) 2017
  • GBS792 - CMDB Seminar (Spring Term 2017) 2017
  • VIS700 - Vision-Related Lit Review (Spring Term 2017) 2017
  • GBS792 - CMDB Seminar (Fall Term 2016) 2016
  • VIS700 - Vision-Related Lit Review (Fall Term 2016) 2016
  • VS113 - Biochemistry of the Eye (Fall Term 2016) 2016
  • VIS700 - Vision-Related Lit Review (Spring Term 2016) 2016
  • VS113 - Biochemistry of the Eye (Fall Term 2015) 2015
  • VIS700 - Vision-Related Lit Review (Fall Term 2015) 2015
  • VIS700 - Vision-Related Lit Review (Spring Term 2015) 2015
  • VS113 - Biochemistry of the Eye (Fall Term 2014) 2014
  • VIS700 - Vision-Related Lit Review (Fall Term 2014) 2014
  • VIS700 - Vision-Related Lit Review (Spring Term 2014) 2014
  • VS113 - Biochemistry of the Eye (Fall Term 2013) 2013
  • VIS700 - Vision-Related Lit Review (Fall Term 2013) 2013
  • VIS700 - Vision-Related Lit Review (Spring Term 2013) 2013
  • VS113 - Biochemistry of the Eye (Fall Term 2012) 2012
  • VIS700 - Vision-Related Lit Review (Fall Term 2012) 2012
  • VIS700 - Vision-Related Lit Review (Spring Term 2012) 2012
  • VS121 - Biochemistry of the Eye (Fall Term 2011) 2011
  • VIS700 - Vision-Related Lit Review (Fall Term 2011) 2011
  • VIS700 - Vision-Related Lit Review (Summer Term 2011) 2011
  • VIS700 - Vision-Related Lit Review (Spring Term 2011) 2011
  • VS121 - Biochemistry of the Eye (Fall Term 2010) 2010
  • STH299 - Interdisciplinary Seminar (Fall Term 2010) 2010
  • VIS700 - Vision-Related Lit Review (Fall Term 2010) 2010
  • VIS700 - Vision-Related Lit Review (Summer Term 2010) 2010
  • VIS700 - Vision-Related Lit Review (Spring Term 2010) 2010
  • STH299 - Interdisciplinary Seminar (Fall Term 2009) 2009
  • VIS700 - Vision-Related Lit Review (Fall Term 2009) 2009
  • OPVS111 - Basic Science/Clinical Opt I (Fall Term 2009) 2009
  • VIS700 - Vision-Related Lit Review (Summer Term 2009) 2009
  • Education And Training

  • Doctor of Philosophy in Biochemistry, Brandeis University
  • Full Name

  • Alecia Gutierrez
  • Blazerid

  • agross