Positions

Overview

  • Dr. Bansal's research interest focuses on adaptive T-cell responses in HIV-1 transmission and pathogenesis. She's especially interested in understanding the role of HIV-1 specific CD8 and CD4 T-cells and their interplay with the host genetics in influencing the course of HIV-1 disease. This basic information is imperative for HIV-1 vaccine design as the correlates of immune protection are yet unknown. She is also interested in studying the role of T cell in HIV associated cancers.
  • Selected Publications

    Academic Article

    Year Title Altmetric
    2018 Antisense-derived HIV-1 cryptic epitopes are not major drivers of viral evolution during the acute phase of infectionJournal of Virology.  92. 2018
    2018 Tetraspanin blockage reduces exosome-mediated HIV-1 entryArchives of Virology.  163:1683-1689. 2018
    2018 Herpes Zoster in Persons Living with HIV-1 Infection: Viremia and Immunological Defects Are Strong Risk Factors in the Era of Combination Antiretroviral Therapy.Frontiers in Public Health.  6:70. 2018
    2017 Role of TIM-4 in exosome-dependent entry of HIV-1 into human immune cellsInternational Journal of Nanomedicine.  12:4823-4833. 2017
    2016 Impact of pre-Adapted HIV transmissionNature Medicine.  22:606-613. 2016
    2016 HIV-1-specific CD8 T cells exhibit limited cross-reactivity during acute infectionJournal of Immunology.  196:3276-3286. 2016
    2016 HIV-1 latency and virus production from unintegrated genomes following direct infection of resting CD4 T cellsRetrovirology.  13. 2016
    2016 Balance between transmitted HLA preadapted and nonassociated polymorphisms is a major determinant of HIV-1 disease progressionJournal of Experimental Medicine.  213:2049-2063. 2016
    2015 Normal T-cell activation in elite controllers with preserved CD4 + T-cell countsAIDS.  29:2245-2254. 2015
    2015 The HIV-1 Antisense Protein (ASP) induces CD8 T cell responses during chronic infectionRetrovirology.  12. 2015
    2015 Enhanced recognition of HIV-1 cryptic epitopes restricted by HLA Class I alleles associated with a favorable clinical outcomeJournal of Acquired Immune Deficiency Syndromes and Human Retrovirology.  70:1-8. 2015
    2015 HLA Class-II Associated HIV Polymorphisms Predict Escape from CD4+ T Cell ResponsesPLoS Pathogens.  11. 2015
    2014 Human Immunodeficiency Virus VaccinesInfectious Disease Clinics of North America.  28:615-631. 2014
    2014 Characterization of programmed death-1 homologue-1 (PD-1H) expression and function in normal and HIV infected individualsPLoS ONE.  9. 2014
    2014 Characterization of T-Cell responses to cryptic epitopes in recipients of a noncodon-optimized HIV-1 VaccineJournal of Acquired Immune Deficiency Syndromes and Human Retrovirology.  65:142-150. 2014
    2014 Effects of atorvastatin and pravastatin on immune activation and T-cell function in antiretroviral therapy-suppressed HIV-1-infected patientsAIDS.  28:2627-2631. 2014
    2014 Immune activation is associated with CD8 T cell interleukin-21 production in HIV-1-infected individualsJournal of Virology.  88:10259-10263. 2014
    2013 HIV-specific CD8+ T cells from elite controllers are primed for survivalJournal of Virology.  87:5170-5181. 2013
    2012 Protocol for analyzing human leukocyte antigen variants and sexually transmitted infections: From genotyping to immunoassaysMethods in Molecular Biology.  903:359-380. 2012
    2011 Interleukin-2 production by polyfunctional HIV-1-specific CD8 T cells is associated with enhanced viral suppressionJournal of Acquired Immune Deficiency Syndromes and Human Retrovirology.  58:132-140. 2011
    2011 CD8 T-cell proliferative capacity is compromised in primary HIV-1 infectionJournal of Acquired Immune Deficiency Syndromes.  56:213-221. 2011
    2011 Interleukin-21-producing HIV-1-specific CD8 T cells are preferentially seen in elite controllersJournal of Virology.  85:2316-2324. 2011
    2010 Enhanced induction of HIV-specific cytotoxic t lymphocytes by dendritic cell-targeted delivery of SOCS-1 siRNAMolecular Therapy.  18:2028-2037. 2010
    2010 CD8 T cell response and evolutionary pressure to HIV-1 cryptic epitopes derived from antisense transcriptionJournal of Experimental Medicine.  207:51-59. 2010
    2009 P16-04. Cryptic CTL epitopes derived from antisense transcription are frequently recognized in HIV-1 infectionRetrovirology.  6. 2009
    2008 Multifunctional T-cell characteristics induced by a polyvalent DNA prime/protein boost human immunodeficiency virus type 1 vaccine regimen given to healthy adults are dependent on the route and dose of administrationJournal of Virology.  82:6458-6469. 2008
    2008 Transmission of HIV-1 Gag immune escape mutations is associated with reduced viral load in linked recipientsJournal of Experimental Medicine.  205:1009-1017. 2008
    2008 Treatment response in acute/early infection versus advanced AIDS: Equivalent first and second phases of HIV RNA declineAIDS.  22:957-962. 2008
    2007 Immunological control of chronic HIV-1 infection: HLA-mediated immune function and viral evolution in adolescentsAIDS.  21:2387-2397. 2007
    2007 Functionally competent antigen-specific Cd127hi memory CD8 + T cells are preserved only in HIV-infected individuals receiving early treatmentJournal of Infectious Diseases.  195:108-117. 2007
    2006 Interleukin-2 reconstitutes defective human immunodeficiency virus (HIV), and cytomegalovirus (CMV) specific CD8+ T cell proliferation in HIV infectionJournal of Medical Virology.  78:1147-1157. 2006
    2006 Group M-based HIV-1 Gag peptides are frequently targeted by T cells in chronically infected US and Zambian patientsAIDS.  20:353-360. 2006
    2005 Characterization of functional and phenotypic changes in anti-Gag vaccine-induced T cell responses and their role in protection after HIV-1 infectionProceedings of the National Academy of Sciences.  102:4512-4517. 2005
    2005 CD8 T-cell responses in early HIV-1 infection are skewed towards high entropy peptidesAIDS.  19:241-250. 2005
    2003 T Cell Responses in HIV Type 1-Infected Adolescent Minorities Share Similar Epitope Specificities with Whites Despite Significant Differences in HLA Class I AllelesAIDS Research and Human Retroviruses.  19:1017-1026. 2003
    2003 Cross-reactive CD8+ T cell epitopes identified in US adolescent minoritiesJournal of Acquired Immune Deficiency Syndromes.  33:426-438. 2003
    2002 Magnitude of functional CD8+ T-cell responses to the Gag protein of human immunodeficiency virus type 1 correlates inversely with viral load in plasmaJournal of Virology.  76:2298-2305. 2002
    2000 Characterization of the R572T point mutant of a putative cleavage site in human foamy virus envJournal of Virology.  74:2949-2954. 2000
    2000 A significant number of human immunodeficiency virus epitope-specific cytotoxic T lymphocytes detected by tetramer binding do not produce gamma interferonJournal of Virology.  74:10249-10255. 2000
    1999 An endoplasmic reticulum retrieval signal partitions human foamy virus maturation to intracytoplasmic membranesJournal of Virology.  73:7210-7217. 1999
    1998 Membrane organization of bluetongue virus nonstructural glycoprotein NS3Journal of Virology.  72:3362-3369. 1998
    1997 Characterization of the polyhedrin gene of Spodoptera litura nuclear polyhedrosis virusVirus Genes.  14:175-180. 1997
    1997 Expression of lacZ reporter gene under the control of the polyhedrin promoter of Spodoptera litura nuclear polyhedrosis virusGene.  190:145-150. 1997
    1997 Hemagglutinin specificity and neuraminidase coding capacity of neuraminidase-deficient influenza virusesVirology.  229:155-165. 1997
    1995 Molecular Basis for the Resistance of Influenza Viruses to 4-Guanidino-Neu5Ac2enVirology.  214:642-646. 1995

    Research Overview

  • HIV-1, Vaccines, Infectious Diseases, T cell immunology
  • Teaching Overview

  • I have taught HIV-1 virology and immunology to undergraduate and graduate students working in an Infectious Diseases Laboratory.
  • Education And Training

  • Doctor of Philosophy in Virology, 1996
  • University of Alabama University of Alabama, Postdoctoral Fellowship 2001
  • Full Name

  • Anju Bansal