Positions

Overview

  • Dr. Bansal's research interest focuses on adaptive T-cell responses in HIV-1 transmission and pathogenesis. She's especially interested in understanding the role of HIV-1 specific CD8 and CD4 T-cells and their interplay with the host genetics in influencing the course of HIV-1 disease. This basic information is imperative for HIV-1 vaccine design as the correlates of immune protection are yet unknown. She is also interested in studying the role of T cell in HIV associated cancers.
  • Selected Publications

    Academic Article

    Year Title Altmetric
    2019 CD8 T cells targeting adapted epitopes in chronic HIV infection promote dendritic cell maturation and CD4 T cell trans-infection 2019
    2018 Antisense-derived HIV-1 cryptic epitopes are not major drivers of viral evolution during the acute phase of infection 2018
    2018 Tetraspanin blockage reduces exosome-mediated HIV-1 entry 2018
    2018 Herpes Zoster in Persons Living with HIV-1 Infection: Viremia and Immunological Defects Are Strong Risk Factors in the Era of Combination Antiretroviral Therapy. 2018
    2017 Role of TIM-4 in exosome-dependent entry of HIV-1 into human immune cells 2017
    2016 Impact of pre-Adapted HIV transmission 2016
    2016 HIV-1-specific CD8 T cells exhibit limited cross-reactivity during acute infection 2016
    2016 HIV-1 latency and virus production from unintegrated genomes following direct infection of resting CD4 T cells 2016
    2016 Balance between transmitted HLA preadapted and nonassociated polymorphisms is a major determinant of HIV-1 disease progression 2016
    2015 Normal T-cell activation in elite controllers with preserved CD4 + T-cell counts 2015
    2015 The HIV-1 Antisense Protein (ASP) induces CD8 T cell responses during chronic infection 2015
    2015 Enhanced recognition of HIV-1 cryptic epitopes restricted by HLA Class I alleles associated with a favorable clinical outcome 2015
    2015 HLA Class-II Associated HIV Polymorphisms Predict Escape from CD4+ T Cell Responses 2015
    2014 Human Immunodeficiency Virus Vaccines 2014
    2014 Characterization of programmed death-1 homologue-1 (PD-1H) expression and function in normal and HIV infected individuals 2014
    2014 Characterization of T-Cell responses to cryptic epitopes in recipients of a noncodon-optimized HIV-1 Vaccine 2014
    2014 Effects of atorvastatin and pravastatin on immune activation and T-cell function in antiretroviral therapy-suppressed HIV-1-infected patients 2014
    2014 Immune activation is associated with CD8 T cell interleukin-21 production in HIV-1-infected individuals 2014
    2013 HIV-specific CD8+ T cells from elite controllers are primed for survival 2013
    2012 Protocol for analyzing human leukocyte antigen variants and sexually transmitted infections: From genotyping to immunoassays 2012
    2011 Interleukin-2 production by polyfunctional HIV-1-specific CD8 T cells is associated with enhanced viral suppression 2011
    2011 CD8 T-cell proliferative capacity is compromised in primary HIV-1 infection 2011
    2011 Interleukin-21-producing HIV-1-specific CD8 T cells are preferentially seen in elite controllers 2011
    2010 Enhanced induction of HIV-specific cytotoxic t lymphocytes by dendritic cell-targeted delivery of SOCS-1 siRNA 2010
    2010 CD8 T cell response and evolutionary pressure to HIV-1 cryptic epitopes derived from antisense transcription 2010
    2009 P16-04. Cryptic CTL epitopes derived from antisense transcription are frequently recognized in HIV-1 infection 2009
    2008 Multifunctional T-cell characteristics induced by a polyvalent DNA prime/protein boost human immunodeficiency virus type 1 vaccine regimen given to healthy adults are dependent on the route and dose of administration 2008
    2008 Transmission of HIV-1 Gag immune escape mutations is associated with reduced viral load in linked recipients 2008
    2008 Treatment response in acute/early infection versus advanced AIDS: Equivalent first and second phases of HIV RNA decline 2008
    2007 Immunological control of chronic HIV-1 infection: HLA-mediated immune function and viral evolution in adolescents 2007
    2007 Functionally competent antigen-specific Cd127hi memory CD8 + T cells are preserved only in HIV-infected individuals receiving early treatment 2007
    2006 Interleukin-2 reconstitutes defective human immunodeficiency virus (HIV), and cytomegalovirus (CMV) specific CD8+ T cell proliferation in HIV infection 2006
    2006 Group M-based HIV-1 Gag peptides are frequently targeted by T cells in chronically infected US and Zambian patients 2006
    2005 Characterization of functional and phenotypic changes in anti-Gag vaccine-induced T cell responses and their role in protection after HIV-1 infection 2005
    2005 CD8 T-cell responses in early HIV-1 infection are skewed towards high entropy peptides 2005
    2003 T Cell Responses in HIV Type 1-Infected Adolescent Minorities Share Similar Epitope Specificities with Whites Despite Significant Differences in HLA Class I Alleles 2003
    2003 Cross-reactive CD8+ T cell epitopes identified in US adolescent minorities 2003
    2002 Magnitude of functional CD8+ T-cell responses to the Gag protein of human immunodeficiency virus type 1 correlates inversely with viral load in plasma 2002
    2000 Characterization of the R572T point mutant of a putative cleavage site in human foamy virus env 2000
    2000 A significant number of human immunodeficiency virus epitope-specific cytotoxic T lymphocytes detected by tetramer binding do not produce gamma interferon 2000
    1999 An endoplasmic reticulum retrieval signal partitions human foamy virus maturation to intracytoplasmic membranes 1999
    1998 Membrane organization of bluetongue virus nonstructural glycoprotein NS3 1998
    1997 Characterization of the polyhedrin gene of Spodoptera litura nuclear polyhedrosis virus 1997
    1997 Expression of lacZ reporter gene under the control of the polyhedrin promoter of Spodoptera litura nuclear polyhedrosis virus 1997
    1997 Hemagglutinin specificity and neuraminidase coding capacity of neuraminidase-deficient influenza viruses 1997
    1995 Molecular Basis for the Resistance of Influenza Viruses to 4-Guanidino-Neu5Ac2en 1995

    Research Overview

  • HIV-1, Vaccines, Infectious Diseases, T cell immunology
  • Investigator On

  • Vaccine and Treatment Evaluation Units  awarded by VANDERBILT UNIVERSITY MEDICAL CENTER 2014 - 2023
  • Defining the Biological Relevance of HIV-1 Adaptation to CD4 T Cell Responses  awarded by National Institute of Allergy and Infectious Diseases/NIH/DHHS 2017 - 2022
  • Immunologic Health in Aging PLWH  awarded by National Institute of Allergy and Infectious Diseases/NIH/DHHS 2018 - 2020
  • CTL and HIV Polymorphisms in Heterosexual Transmission  awarded by Emory University 2015 - 2020
  • Multidisciplinary Evaluation of Accelerated Aging in HIV-1 Infection  awarded by National Institute on Aging/NIH/DHHS 2017 - 2020
  • A Rational Approach for HIV Vaccine T Cell Epitope Selection  awarded by National Institute of Allergy and Infectious Diseases/NIH/DHHS 2014 - 2019
  • UAB Center for AIDS Research  awarded by National Institute of Allergy and Infectious Diseases/NIH/DHHS 2014 - 2019
  • Private Grant  awarded by Pfizer Inc., U.S. Pharmaceuticals Group 2016 - 2017
  • Oxidative Stress and T Cell Balance: Effect on Pulmonary Tuberculosis During HIV  awarded by National Heart, Lung, and Blood Institute/NIH/DHHS 2014 - 2016
  • HIV-1 Cryptic Epitopes: Implications for Vaccine Design  awarded by National Institute of Allergy and Infectious Diseases/NIH/DHHS 2009 - 2015
  • CTL and HIV Polymorphisms in Heterosexual Transmission  awarded by Emory University 2010 - 2015
  • Analysis of Variant Epitope Specific CD8 T-Cells to Optimize HIV Vaccine Design  awarded by National Institute of Allergy and Infectious Diseases/NIH/DHHS 2012 - 2014
  • UAB Center for AIDS Research  awarded by National Institute of Allergy and Infectious Diseases/NIH/DHHS 2009 - 2014
  • Mapping Novel Subdominant B*5701 Epitopes in Conserved Regions of the HIV Proteome  awarded by UNIVERSITY OF TEXAS 2009 - 2013
  • Teaching Overview

  • I have taught HIV-1 virology and immunology to undergraduate and graduate students working in an Infectious Diseases Laboratory.
  • Education And Training

  • University of Alabama University of Alabama, Postdoctoral Fellowship 2001
  • Full Name

  • Anju Bansal